Recent Advances in the MCRs Synthesis of Chromenes: A Review

Mamaghani, Manouchehr; Nia, Roghayeh Hossein; Tavakoli, Fateme; Jahanshahi, Parivash

doi:10.2174/1385272822666180530104302

Cited by 33 publications

(13 citation statements)

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“…Almost all the reported methods require costly catalysts with low recyclability. [74,75] [46] Moreover, the catalyst was found to be reusable after six runs. This guanylguanidine functionalized catalyst offers several advantages such as i) high yield, ii) easy separability, iii) recyclability and iv) no side products.…”

Section: Knoevenagel Condensation Domino Knoevenagel/michael/cyclizat...mentioning

confidence: 93%

Guanylguanidines: Catalyst and Ligand for Organic Transformations

Bankar¹,

Kathuria

2022

ChemistrySelect

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Guanylguanidines are well known for their wide range of therapeutic applications such as antidiabetic, anticancer, antifilarial, antitrypanosomal, antiaging, etc. Apart from this, they have been explored in the field of crystal engineering, organic synthesis as substrate, non‐linear optics etc. Their metal complexation ability and superbasic nature has paved their way in the field of organocatalysis. In the recent past, various guanylguanidine derivatives have been synthesized and have proven to be excellent catalysts in several organic reactions which include transesterification, C−C and C−N coupling, oxidation, reduction, Beckmann rearrangement etc. However, the limited studies call for more focused research in this direction to fasten the process of development of environmental‐friendly methods. In this review, a comprehensive and systematic discussion of guanylguanidine based catalysts and their applications in various organotransformations has been compiled and discussed meticulously. This review aims to highlight guanylguanidine moiety as a potential catalyst that can be utilized for design and development of novel guanylguanidine based catalysts.

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Section: Knoevenagel Condensation Domino Knoevenagel/michael/cyclizat...mentioning

confidence: 93%

Guanylguanidines: Catalyst and Ligand for Organic Transformations

Bankar¹,

Kathuria

2022

ChemistrySelect

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“…A plethora of work has been done on the synthesis of pyran derivatives and several review articles highlighting the synthesis and importance of chromenes, 2H-chromenes, fused chromenes, and nitrochromenes have been published. [5,[34][35][36][37] Li and coworkers discussed the role of magnetic nanocatalysis only for the synthesis of pyran scaffolds. [38] The exhaustive literature studies showed that this article shall provide pragmatic information summarizing the vast synthetic approaches for 4H-pyran (4H-chromene) scaffolds.…”

Section: Introductionmentioning

confidence: 99%

An overview of recent advances in the catalytic synthesis of substituted pyrans

Agarwal¹,

Sethiya²,

Soni³

et al. 2022

Applied Organom Chemis

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Substituted pyrans (4H‐Chromenes) are the most significant structural scaffolds in synthetic and medicinal chemistry. They are found in an array of natural products, medicines, and phytochemical compounds, bearing an explicit of pharmacological activities. The structural importance of substituted pyrans has elicited a huge upsurge in the field of synthesis and biology. Different synthetic approaches of 4H‐chromene scaffolds have been discussed systematically to emphasize their significance in the scientific world. The present article summarizes the different synthetic strategies of substituted pyran derivatives via acid‐base catalysis, ionic liquids, nanomaterials, deep eutectic solvents, bio‐based, visible light, metal catalyzed, and so forth developed in the last decade. Moreover, this article will definitely contribute to the scientific world for developing synthetically and biologically important pyran analogs.

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“…They exist in the widespread natural compounds and display numerous pharmaceutical properties such as anti-inflammatory, anti-oxidant, anti-bacterial, anti-cancer, anti-coagulant, anti-microbial, anti-Alzheimer and anti-HIV 29 , 30 . 2-Amino-3-cyano-4 H -chromenes are generally prepared by three-component reactions involving the cyclocondensation of various types of aldehydes, malonates and β-dicarbonyl compounds or activated phenols 31 . Numerous modified catalysts have been used for the elaboration of 2-amino-3-cyano-4 H -chromenes and their derivatives 32 – 37 .…”

Section: Introductionmentioning

confidence: 99%

A novel base-metal multifunctional catalyst for the synthesis of 2-amino-3-cyano-4H-chromenes by a multicomponent tandem oxidation process

Chahkamali

Sobhani

Sansano

2022

Sci Rep

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A novel base-metal multifunctional nanomagnetic catalyst is prepared by the immobilization of tungstate anions onto γ-Fe2O3 supported with imidazolium moieties. The (γ-Fe2O3-Im-Py)2WO4 was fully characterized using FT-IR, XPS, TEM, FESEM, ICP, TGA, VSM and XRD and used as a multifunctional heterogeneous catalyst for the synthesis of 2-amino-3-cyano-4H-chromenes via a multicomponent tandem oxidation process starting from alcohols under solvent-free conditions. During this process, tungstate catalyzes the oxidation of a wide range of alcohols in the presence of TBHP as a clean source. The in-situ formed aldehydes are condensed with malononitrile and β-dicarbonyl compounds/naphthols/4-hydroxycumarin through promotion by pyridine and imidazolium moieties of the catalyst. By this method, a variety of 2-amino-3-cyano-4H-chromenes are generated in good to high yields from alcohols as inexpensive and easily available starting materials. The catalyst is recovered easily by the aid of an external magnetic field and reused in five successive runs with insignificant decreasing activity.

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Recent Advances in the MCRs Synthesis of Chromenes: A Review

Cited by 33 publications

References 0 publications

Guanylguanidines: Catalyst and Ligand for Organic Transformations

Guanylguanidines: Catalyst and Ligand for Organic Transformations

An overview of recent advances in the catalytic synthesis of substituted pyrans

A novel base-metal multifunctional catalyst for the synthesis of 2-amino-3-cyano-4H-chromenes by a multicomponent tandem oxidation process

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