Recent advances in the nanoarchitectonics of metal–organic frameworks for light-activated tumor therapy

Duan, Huijuan; Wang, Fang; Xu, Weizhe; Sheng, Gang; Sun, Zhaogang; Chu, Hongqian

doi:10.1039/d3dt02725b

Cited by 9 publications

(1 citation statement)

References 126 publications

(163 reference statements)

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“…The application of MOFs in cancer therapy represents a rapidly evolving and cuttingedge field within biomedical research. Key challenges and opportunities in MOF-based cancer diagnosis and therapy are being explored, focusing on frequently studied MOFs like Isoreticular MOF (IRMOF), Zeolitic imidazolate framework (ZIF), Materials of Institute Lavoisier (MIL), and porous coordination network (PCN), University of Oslo (UiO) [19]. Additionally, various anti-tumor therapies, such as drug delivery (DD), chemodynamic therapy (CDT), sonodynamic therapy (SDT), photothermal therapy (PTT), photodynamic therapy (PDT), starvation therapy (ST), and multimodal synergistic therapy (MST), have been investigated, elucidating the roles and efficacy of MOFs in these treatment modalities (Figure 1) [20][21][22][23][24][25][26].…”

Section: Introductionmentioning

confidence: 99%

Metal–Organic Framework Nanomaterials as a Medicine for Catalytic Tumor Therapy: Recent Advances

Zhang,

Li,

Liu

et al. 2024

Nanomaterials

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Nanomaterials, with unique physical, chemical, and biocompatible properties, have attracted significant attention as an emerging active platform in cancer diagnosis and treatment. Amongst them, metal–organic framework (MOF) nanostructures are particularly promising as a nanomedicine due to their exceptional surface functionalities, adsorption properties, and organo-inorganic hybrid characteristics. Furthermore, when bioactive substances are integrated into the structure of MOFs, these materials can be used as anti-tumor agents with superior performance compared to traditional nanomaterials. In this review, we highlight the most recent advances in MOFs-based materials for tumor therapy, including their application in cancer treatment and the underlying mechanisms.

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Section: Introductionmentioning

confidence: 99%

Metal–Organic Framework Nanomaterials as a Medicine for Catalytic Tumor Therapy: Recent Advances

Zhang,

Li,

Liu

et al. 2024

Nanomaterials

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Nanoarchitectonics for Biomedical Research: Post‐Nanotechnology Materials Approach for Bio‐Active Application

Ariga

2024

Advanced NanoBiomed Research

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Nanoarchitectonics, as a post‐nanotechnology concept, represents a methodology for the construction of functional materials employing atoms, molecules, and nanomaterials as essential components. The overarching objective of nanoarchitectonics is to develop functional systems comprising multiple functional units assembled in a hierarchical manner, as observed in biological systems. Nevertheless, the construction of such functional systems is a challenging endeavor. It would be prudent, therefore, to initially focus on the development of functional materials that interact with the complex functional structures of living organisms. Accordingly, this review article addresses the topic of nanoarchitecture as it pertains to biomedical applications. This article examines the current trends in research and presents examples of studies that support the concept of nanoarchitectonics and its applications in biomedical fields. The examples presented are as follows: i) molecular nanoarchitectonics developments, which are mainly based on molecular design and assembly; ii) material nanoarchitectonics examples, which are mainly based on material design using nanomaterials as components; and iii) biomedical applications with porous materials, which will be summarized under the heading of pore‐engineered nanoarchitectonics due to their special structure. Finally, the review provides an overview of these examples and discusses future prospects.

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Metal‐Organic Frameworks (MOFs): Classification, Synthesis, Modification, and Biomedical Applications

Wang,

Yao,

et al. 2024

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Metal‐organic frameworks (MOFs) are a new variety of solid crystalline porous functional materials. As an extension of inorganic porous materials, it has made important progress in preparation and application. MOFs are widely used in various fields such as gas adsorption storage, drug delivery, sensing, and biological imaging due to their high specific surface area, porosity, adjustable pore size, abundant active sites, and functional modification by introducing groups. In this paper, the types of MOFs are classified, and the synthesis methods and functional modification mechanisms of MOFs materials are summarized. Finally, the application prospects and challenges of metal‐organic framework materials in the biomedical field are discussed, hoping to promote their application in multidisciplinary fields.

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Recent advances in the nanoarchitectonics of metal–organic frameworks for light-activated tumor therapy

Abstract: Metal-organic frameworks (MOFs) have received extensive attention in tumor therapy because of their advantages, including large specific surface area, regular pore size, adjustable shape, and facial functionalization. MOFs are porous...

Cited by 9 publications

References 126 publications

Metal–Organic Framework Nanomaterials as a Medicine for Catalytic Tumor Therapy: Recent Advances

Metal–Organic Framework Nanomaterials as a Medicine for Catalytic Tumor Therapy: Recent Advances

Nanoarchitectonics for Biomedical Research: Post‐Nanotechnology Materials Approach for Bio‐Active Application

Metal‐Organic Frameworks (MOFs): Classification, Synthesis, Modification, and Biomedical Applications

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