Recent advances in the synthesis of taxoids: 2015-2020

Abstract

Taxol is a highly oxygenated, polycyclic diterpene first isolated from the bark of the Pacific yew tree. The impressive antitumor activity of this compound led to intense synthetic activity over the past 30 years. The first syntheses were reported more than 25 years ago, and earlier synthetic efforts have been amply reviewed. This review will focus on the literature for the period 2015-2020 including formal and total syntheses of taxol, 1-hydroxytaxinine, taxabaccatin III, and canataxpropellane.