Recent advances in the synthesis of bridgehead (or ring-junction) nitrogen heterocycles via transition metal-catalyzed C–H bond activation and functionalization

Abstract

Bridgehead nitrogen (or ring-junction nitrogen) heterocycles are one of the most privileged scaffolds for synthetic chemistry and medicinal chemistry. For decades, transition metal-catalyzed C-H activation has provided straightforward access to...

Pd(ii)/Lewis acid catalyzed regioselective olefination of indole with dioxygen

“…Transition metal catalyzed C–H bond activation and functionalization has emerged as a powerful and promising protocol for the construction of versatile pharmaceutical molecules and functional materials. 1–5 Among all these metals, palladium is the most popular and efficient catalyst because of its high activity in C–H activation. 6–8 However, in many cases, to accomplish the efficient Pd( ii )/Pd(0) catalytic cycle, Cu( ii ) salts are popularly added as cocatalysts or oxidants for the regeneration of the active Pd( ii ) species from the reduced Pd(0), which was originally inspired by the Wacker oxidation.…”

Recent advances in the tandem copper-catalyzed Ullmann–GoldbergN-arylation–cyclization strategies

“…Organotransition metal-catalyzed protocols play a pivotal role in synthetic organic transformations. 1 Among the transition metal catalysts, copper catalysts have grabbed great attention due to their inexpensiveness, lesser toxicity and abundance. As early as 1901, Ullmann and Bielecki reported the synthesis of a biaryl compound in which two molecules of ortho -bromonitrobenzene react in the presence of stoichiometric amounts of copper powder enabling the homo-coupling of the two molecules of aryl halide to give the corresponding biaryl derivative.…”

Recent Strategies in Transition-Metal-Catalyzed Sequential C–H Activation/Annulation for One-Step Construction of Functionalized Indazole Derivatives

“…Therefore, considerable attempts have been devoted to constructing these biologically critical scaffolds more efficiently, although the exploration of novel atom-economical strategies to produce these unique scaffolds is still a challenging topic. Recently, a transition-metal-catalyzed C−H bond activation and cyclization sequence [ 35 , 36 , 37 , 38 , 39 , 40 ] has received significant attention to provide these structures.…”