Recent advances in the synthesis of fluorinated hydrazones

Guo, Rui; Chen, Junting

doi:10.1039/c8ra02533a

Cited by 14 publications

(4 citation statements)

References 56 publications

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“…Recently hydrazone derivatives display a key important role in medicinal, organic and inorganic chemistry as a result of their structural varieties, preparative accessibilities structures and meaningful biological activities . Hydrazone compounds are primarily a Schiff‐base group of materials having a secondary amine proton including a gorgeous family of derivatives in a variance of research areas, such as chemical and biosensors, nonlinear optics, and a variety of medical applications . Moreover, hydrazones are well known to exhibit a great ability to form highly stable complexes with several transition metals .…”

Section: Introductionmentioning

confidence: 99%

Synthesis of novel VO (II)‐thaizole complexes; spectral, conformational characterization, MOE‐docking and genotoxicity

El‐Metwaly

Althagafi

Katouah

et al. 2019

Applied Organom Chemis

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New VO (II)‐thaizolyl hydrazine complexes were synthesized and characterized by analytical, spectral and theoretical techniques. Bi‐nuclear complexes were suggested for all synthesizes upon neutral poly‐dentate mode of bonding. UV–Vis and EPR spectra, proposed two structural geometries as, square‐planer and octahedral. TGA confirmed the contribution of solvent molecules through physical and/or coordinate‐bonding. XRD parameters calculated, displayed outstanding nanometer‐sizes for all nano‐crystalline compounds, which suffering slight imperfections. Also, SEM images showed, spherical‐shape that observed for most topographic particulates. Conformational study executed for all new synthesizes, demonstrated their optimized structural‐forms. Furthermore, important physical parameters were computed that predict essential characteristics as, biological efficiency. Predictable parameters as softness and electrophilicity, point to priority of VO (II)‐4d complex. Genotoxic study, was already examined, for all new synthesizes, against CT‐DNA and displayed complete deterioration for DNA, by influence of most tested compounds. Moreover, MOE‐docking technique, was executed against receptors of Y‐family DNA‐polymerase (4irk) and Key‐Enzyme Linking‐Metabolic Inflammation (4cyf). This docking study displayed the following ascending order; VO (II)‐4c,4irk ˃ VO (II)‐4d,4cyf ˃ VO (II)‐4c, 4cyf ˃ VO (II)‐4b, 4cyf, based on scoring‐energy values. This study concluded with promising prediction of these complexes in relation to DNA‐polymerase as well as inflammation enzyme that compared with known anti‐inflammatory drug (meloxicam).

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Section: Introductionmentioning

confidence: 99%

Synthesis of novel VO (II)‐thaizole complexes; spectral, conformational characterization, MOE‐docking and genotoxicity

El‐Metwaly

Althagafi

Katouah

et al. 2019

Applied Organom Chemis

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“…Hydrazones are originally a Schiff-base group of materials possessing a secondary amine proton comprising an important category of compounds in a diversity of research fields, such as nonlinear optics, sensors, and a variety of biological and medical applications [16][17][18][19][20][21][22][23][24][25][26].…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Solvatochromic Performance, pH Sensing, Dyeing Ability, and Antimicrobial Activity of Novel Hydrazone Dyestuffs

Khattab

Allam

Othman

et al. 2019

Journal of Chemistry

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New tricyanofuran intramolecular charge transfer dyes comprising the hydrazone group were prepared and fully characterized in order to study their possible solvatochromism, dyeing ability, and antimicrobial activity. e preparation of the hydrazone dyes was achieved in relatively good yields starting from different aromatic amines. e hydrazone functional group was presented via the azo-coupling reaction of the tricyanofuran compound by the properly substituted diazonium chloride. Chemical structures of the prepared hydrazones were confirmed via nuclear magnetic resonance spectroscopy ( 1 H-and 13 C-NMR), Fourier-transform infrared spectroscopy (FT-IR), and elemental analysis (C, H, and N). e UV-visible absorption spectra of the produced sensor colorants displayed interesting solvatochromism in solvents with a different polarity, which was found to be affected by the substituents bonded to the aromatic hydrazone moiety. e pH molecular switching was investigated through tuning the intramolecular charge transfer stimulated by the reversible deprotonation/protonation process in acetonitrile solution showing color change from yellow to purple. e produced disperse dyestuffs were employed for dyeing polyester fibers to introduce acceptable color strength and colorfastness properties. Moreover, the dyes verified a weak to moderate antimicrobial activity against some selected pathogens, including S. aureus, E. coli, and Candida albicans.

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“…managed to demonstrate a photocatalytic system where Pt/g‐C 3 N 4 catalyst was able to reduce water into hydrogen and subsequently utilize the H 2 for the reduction of HMF into DHMF. [ 122 ] There are many cases where hydrogen is directly consumed in the reaction, in the form of H•. [ 123,124 ] This sophisticated approach was thoroughly investigated by Zhao and collaborators, in their work a Pd 1 ‐mpg‐C 3 N 4 was used for the photo‐induced hydrogenation of styrene by water.…”

Section: Photocatalytic‐driven Hydrogenationmentioning

confidence: 99%

A Solar to Chemical Strategy: Green Hydrogen as a Means, Not an End

Diab,

da Silva,

Rocha

et al. 2023

Global Challenges

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Green hydrogen is the key to the chemical industry achieving net zero emissions. The chemical industry is responsible for almost 2% of all CO2 emissions, with half of it coming from the production of simple commodity chemicals, such as NH3, H2O2, methanol, and aniline. Despite electrolysis driven by renewable power sources emerging as the most promising way to supply all the green hydrogen required in the production chain of these chemicals, in this review, it is worth noting that the photocatalytic route may be underestimated and can hold a bright future for this topic. In fact, the production of H2 by photocatalysis still faces important challenges in terms of activity, engineering, and economic feasibility. However, photocatalytic systems can be tailored to directly convert sunlight and water (or other renewable proton sources) directly into chemicals, enabling a solar‐to‐chemical strategy. Here, a series of recent examples are presented, demonstrating that photocatalysis can be successfully employed to produce the most important commodity chemicals, especially on NH3, H2O2, and chemicals produced by reduction reactions. The replacement of fossil‐derived H2 in the synthesis of these chemicals can be disruptive, essentially safeguarding the transition of the chemical industry to a low‐carbon economy.

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Recent advances in the synthesis of fluorinated hydrazones

Abstract: Fluorinated compounds are widely used in pharmaceuticals, agrochemicals, and materials.

Cited by 14 publications

References 56 publications

Synthesis of novel VO (II)‐thaizole complexes; spectral, conformational characterization, MOE‐docking and genotoxicity

Synthesis of novel VO (II)‐thaizole complexes; spectral, conformational characterization, MOE‐docking and genotoxicity

Synthesis, Solvatochromic Performance, pH Sensing, Dyeing Ability, and Antimicrobial Activity of Novel Hydrazone Dyestuffs

A Solar to Chemical Strategy: Green Hydrogen as a Means, Not an End

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