Recent advances in the total synthesis of 2,7′-cyclolignans

Abstract

Synthetic progress of bioactive 2,7′-cyclolignans was reviewed. After a short introduction to the biosynthesis and chemoenzymatic synthesis, chemical synthesis of various aryltetralin, dihydronaphthalene and 7′-arylnaphthalene types of these lignans were...

A two carbon homologation of Friedel–Crafts alkylation enabled by photochemical alkene stitching: modular assembly of cyclolignans

“…12 These motifs can further serve as a gateway to 2, 7 0 -cyclolignans containing hydronaphthalene and tetrahydrofuran motifs (Scheme 1c), which are present in a number of bio-active molecules including already approved drugs and anti-microbial, as well as several metabolites. 13 Herein, we report the development of a two carbon homologated variant of Friedel-Crafts alkylation using alkenes as versatile chain elongators (Scheme 1b). Several (hetero)arenes, as well as alkyl precursors, have been explored.…”

“…12 These motifs can further serve as a gateway to 2,7′-cyclolignans containing hydronaphthalene and tetrahydrofuran motifs (Scheme 1c), which are present in a number of bio-active molecules including already approved drugs and anti-microbial, as well as several metabolites. 13…”