Recent advances in the use of inorganic nanomaterials as anti caries agents

Al-Hijazi, Athraa Y.; Hasan, Nada; Nasr, Bassem Karim; Al-Khafaji, Hanadi Hadi Jasim; Al-Khafaji, Buthaina; Alanssari, Bahaa Fawzi Abdah; Jalil, Abduladheem Turki

doi:10.1016/j.heliyon.2023.e15326

Cited by 9 publications

(7 citation statements)

References 129 publications

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“…Back in the 1980s, scientists doped copper materials into topical agents and drinking water to investigate the anticaries effect of copper [10,11]. In recent years, various copperbased nanomaterials with antibacterial properties for caries treatment and prevention have emerged with the development of nanotechnology [12]. Copper-based nanoparticles show excellent antibacterial capabilities due to the high surface-area-to-volume ratio of the nanostructure [13].…”

Section: Introductionmentioning

confidence: 99%

Copper Materials for Caries Management: A Scoping Review

Xu,

Nizami,

Yin

et al. 2023

JFB

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This study comprehensively reviewed the types, properties and potential applications of copper materials for caries management. Two researchers independently searched English publications using PubMed, Scopus and Web of Science. They screened the titles and abstracts of publications presenting original studies for review. They included 34 publications on copper materials, which were categorized as copper and copper alloy materials (13/34, 38%), copper salt materials (13/34, 38%) and copper oxide materials (8/34, 24%). All reported copper materials inhibited the growth of cariogenic bacteria such as Streptococcus mutans and Candida albicans. The materials could be doped into topical agents, restorative fillers, dental adhesives, drinking water, dental implants, orthodontic appliances, mouthwash and sugar. Most publications (29/34, 83%) were laboratory studies, five (5/34, 14%) were animal studies and only one paper (1/34, 3%) was clinical research. In conclusion, copper and copper alloy materials, copper salt materials and copper oxide materials have an antimicrobial property that inhibits cariogenic bacteria and Candida albicans. These copper materials may be incorporated into dental materials and even drinking water and sugar for caries prevention. Most publications are laboratory studies. Further clinical studies are essential to validate the effectiveness of copper materials in caries prevention.

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Section: Introductionmentioning

confidence: 99%

Copper Materials for Caries Management: A Scoping Review

Xu,

Nizami,

Yin

et al. 2023

JFB

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“…Dental caries, the most common oral health disorder, is a societal disease that affects patients of every age and social group worldwide [ 1 , 2 ]. Its multifactorial mechanism is explained by the loss of minerals from susceptible enamel, cementum, and dentin due to an acidic environment induced by cariogenic microorganisms when physiological remineralization processes are insufficient to restore lost minerals [ 1 , 2 ]. Cariogenic bacteria play an important role in the development of caries.…”

Section: Introductionmentioning

confidence: 99%

“…Cariogenic bacteria play an important role in the development of caries. As such, it can be defined as an infectious, dental plaque-dependent and biofilm-mediated disease [ 1 , 2 ]. Unbalanced mineral loss disrupts the structure of enamel, cementum, and dentin and leads to the development of carious lesions, which seriously impact masticatory function, cause pain, and have a negative aesthetic impact [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

“…Unbalanced mineral loss disrupts the structure of enamel, cementum, and dentin and leads to the development of carious lesions, which seriously impact masticatory function, cause pain, and have a negative aesthetic impact [ 3 ]. As such, carious lesions require clinical intervention: the removal of carious tissue and its replacement with either a direct filling or, in extensive tissue loss, prosthetic restoration [ 1 , 2 ]. Hard tissue loss caused by other factors, such as trauma, requires a similar restoration process [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

“…Currently, RBCs are rapidly developing, with 3D-printable resins or bioactive materials with antibacterial and remineralizing properties being tested and introduced into the dental market [ 1 , 2 , 13 , 14 , 15 , 16 ]. Novel composites seek to not merely replace but fully replicate lost tissues [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

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Considerations about Cytotoxicity of Resin-Based Composite Dental Materials: A Systematic Review

Wiertelak-Makała,

Szymczak-Pajor,

Bociong

et al. 2023

IJMS

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The dental material industry is rapidly developing resin-based composites (RBCs), which find widespread use in a variety of clinical settings. As such, their biocompatibility has gained increasing interest. This literature review presents a summary of research into the cytotoxicity of methacrylate-based composites published from 2017 to 2023. Subject to analysis were 14 in vitro studies on human and murine cell lines. Cytotoxicity in the included studies was measured via MTT assay, LDH assay, and WST-1 assay. The QUIN Risk of Bias Tool was performed to validate the included studies. Included studies (based entirely on the results of in vitro studies) provide evidence of dose- and time-dependent cytotoxicity of dental resin-based composites. Oxidative stress and the depletion of cellular glutathione (GSH) were suggested as reasons for cytotoxicity. Induction of apoptosis by RBCs was indicated. While composites remain the golden standard of dental restorative materials, their potential cytotoxicity cannot be ignored due to direct long-term exposure. Further in vitro investigations and clinical trials are required to understand the molecular mechanism of cytotoxicity and produce novel materials with improved safety profiles.

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Nanotechnology for High‐Performance Textiles: A Promising Frontier for Innovation

et al. 2023

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Nanotechnology embodies a groundbreaking innovation for the textile and apparel industry, facilitating enhancements to the functionality and performance of textiles, including durability, resistance to water, odor, flame, stain, UV‐protection, and antimicrobial properties. Nanotechnology also enables biosensing, drug delivery, energy generation, and storage in textiles. Here, we present a comprehensive overview of the possibilities offered by nanotechnology in the context of high‐performance textiles providing a roadmap for future research and development in this exciting field. We scrutinize the current research on nanotechnology in textiles, exploring various types of nanomaterials and their properties, the methods of incorporating nanomaterials into textiles, and the numerous applications of high‐performance textiles across critical industries such as healthcare, military, sports, fashion, and wearable electronics. We conclude the review with an analysis of the potential health and environmental concerns arising from the use of nanotechnology in textiles, emphasizing the importance of further research in these areas.

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Recent advances in the use of inorganic nanomaterials as anti caries agents

Cited by 9 publications

References 129 publications

Copper Materials for Caries Management: A Scoping Review

Copper Materials for Caries Management: A Scoping Review

Considerations about Cytotoxicity of Resin-Based Composite Dental Materials: A Systematic Review

Nanotechnology for High‐Performance Textiles: A Promising Frontier for Innovation

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