Recent Advances in the Use of Anthelmintics for Treating Nematode Infections

Abstract

The recent trends of parasitic infections in Korea include remarkable decreases of soil-transmitted nematode infections and elimination of lymphatic filariasis. In comparison, enterobiasis (pinworm infection) continues to be prevalent among children and the cases of zoonotic tissue-invading nematode infection are slightly increasing or they are being increasingly diagnosed. In addition, imported parasitoses continue to be problems from the clinical and public health points of

Effect of Mass Drug Administration with a Single Dose of Albendazole on Ascaris lumbricoides and Trichuris trichiura Infection among Schoolchildren in Yangon Region, Myanmar

“…The high sensitivity of A. lumbricoides to benzimidazoles (albendazole and mebendazole) has been well documented [6,7]. The cure rate of albendazole (400 mg) for A. lumbricoides infection was reported to be 82-100% [6] or 93.2-97.3% [7].…”

“…The high sensitivity of A. lumbricoides to benzimidazoles (albendazole and mebendazole) has been well documented [6,7]. The cure rate of albendazole (400 mg) for A. lumbricoides infection was reported to be 82-100% [6] or 93.2-97.3% [7]. However, the sensitivity of T. trichiura to albendazole or mebendazole has been reported to be generally low and unsatisfactory [1,6,7].…”

“…The cure rate of albendazole (400 mg) for A. lumbricoides infection was reported to be 82-100% [6] or 93.2-97.3% [7]. However, the sensitivity of T. trichiura to albendazole or mebendazole has been reported to be generally low and unsatisfactory [1,6,7]. The cure rate of 400 mg single oral dose of albendazole for treating T. trichiura infection was reported to be 27-81% [6] or less, 21.0-42.5% [7].…”

“…Various workers have reported limited efficacy of albendazole and mebendazole for individual treatment of T. trichiura infection [1,[6][7][8][9]. However, these drugs can be used in MDA because of considerable egg reduction rates, 77.0-99.0% [6] or 39.0-60.6% [7].…”

“…Various workers have reported limited efficacy of albendazole and mebendazole for individual treatment of T. trichiura infection [1,[6][7][8][9]. However, these drugs can be used in MDA because of considerable egg reduction rates, 77.0-99.0% [6] or 39.0-60.6% [7]. In particular, a long-term repeated use of albendazole or mebendazole at provincial or national level, up to 10 or more years (once or twice a year), markedly reduced the prevalence of T. trichiura in China [11,12] and also in Cambodia (unpublished observations).…”