Recent advances in therapeutic engineered extracellular vesicles

Yao, Chenlu; Zhang, Hong; Wang, Chao

doi:10.1039/d3nr05470e

Nanoscale

2024

DOI: 10.1039/d3nr05470e

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Recent advances in therapeutic engineered extracellular vesicles

Chenlu Yao,

Hong Zhang,

Chao Wang

Abstract: This review introduces the modified methods of engineered EVs, summarizes the application of engineered EVs in preclinical and clinical trials, and discusses the opportunities and challenges for the clinical translation of surface-engineered EVs.

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References 136 publications

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Platelet Extracellular Vesicles Loaded Gelatine Hydrogels for Wound Care

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Barras,

Nyam‐Erdene

et al. 2024

Adv Healthcare Materials

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Platelet extracellular vesicles (pEVs) isolated from clinical‐grade human platelet concentrates are attracting attention as a promising agent for wound healing therapies. Although pEVs have shown potential for skin regeneration, their incorporation into wound bandages has remained limitedly explored. Herein, gelatine‐based hydrogel (PAH‐G) foams for pEVs loading and release are formulated by crosslinking gelatine with poly(allylamine) hydrochloride (PAH) in the presence of glutaraldehyde and sodium bicarbonate. The optimized PAH‐G hydrogel foam, PAH0.24G37, displayed an elastic modulus G’ = 8.5 kPa at 37 °C and retained a rubbery state at elevated temperatures. The excellent swelling properties of PAH0.24G37 allowed to easily absorb pEVs at high concentration (1 × 1011 particles mL−1). The therapeutic effect of pEVs was evaluated in vivo on a chronic wound rat model. These studies demonstrated full wound closure after 14 days upon treatment with PAH0.24G37@pEVs. The maintenance of a reduced‐inflammatory environment from the onset of treatment promoted a quicker transition to skin remodeling. Promotion of follicle activation and angiogenesis as well as M1–M2 macrophage modulation are evidenced. Altogether, the multifunctional properties of PAH0.24G37@pEVs addressed the complex challenges associated with chronic diabetic wounds, representing a significant advance toward personalized treatment regimens for these conditions.

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Platelet Extracellular Vesicles Loaded Gelatine Hydrogels for Wound Care

Back,

Barras,

Nyam‐Erdene

et al. 2024

Adv Healthcare Materials

View full text Add to dashboard Cite

show abstract

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Recent advances in therapeutic engineered extracellular vesicles

Abstract: This review introduces the modified methods of engineered EVs, summarizes the application of engineered EVs in preclinical and clinical trials, and discusses the opportunities and challenges for the clinical translation of surface-engineered EVs.

Cited by 1 publication

References 136 publications

Platelet Extracellular Vesicles Loaded Gelatine Hydrogels for Wound Care

Platelet Extracellular Vesicles Loaded Gelatine Hydrogels for Wound Care

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