Recent advances in total synthesis of protoberberine and chiral tetrahydroberberine alkaloids

Niu, Zhen-Xi; Wang, Ya-Tao; Wang, Jun-Feng

doi:10.1039/d4np00016a

Cited by 2 publications

(1 citation statement)

References 110 publications

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“…THPBs can be semisynthetically prepared by the reduction of the relatively abundant protoberberines such as berberine, palmatine, and their partially O -demethylated analogs or synthetically prepared via Pictet–Spengler reaction, Bischler–Napieralski reaction, Pomeranz–Fritsch reaction, or Mannich reaction to construct the B-ring and C-ring in sequence …”

Section: Benzylisoquinoline Alkaloids (Bias)mentioning

confidence: 99%

Natural Product-Inspired Dopamine Receptor Ligands

Dorogan,

Namballa,

Harding

2024

J. Med. Chem.

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Due to their evolutionary bias as ligands for biologically relevant drug targets, natural products offer a unique opportunity as lead compounds in drug discovery. Given the involvement of dopamine receptors in various physiological and behavioral functions, they are linked to numerous diseases and disorders such as Parkinson’s disease, schizophrenia, and substance use disorders. Consequently, ligands targeting dopamine receptors hold considerable therapeutic and investigative promise. As this perspective will highlight, dopamine receptor targeting natural products play a pivotal role as scaffolds with unique and beneficial pharmacological properties, allowing for natural product-inspired drug design and lead optimization. As such, dopamine receptor targeting natural products still have untapped potential to aid in the treatment of disorders and diseases related to central nervous system (CNS) and peripheral nervous system (PNS) dysfunction.

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Section: Benzylisoquinoline Alkaloids (Bias)mentioning

confidence: 99%

Natural Product-Inspired Dopamine Receptor Ligands

Dorogan,

Namballa,

Harding

2024

J. Med. Chem.

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Recent Advances in Alkaloids from Papaveraceae in China: Structural Characteristics and Pharmacological Effects

Zhang,

Yang,

Sun

et al. 2024

Molecules

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The Papaveraceae plant family serves as a botanical reservoir for a variety of medicinal compounds that have been traditionally utilized in Chinese medicine for numerous generations. Growing attention towards the pharmaceutical potential of Papaveraceae has resulted in the identification of many alkaloids, which have attracted significant attention from the scientific community because of their structural complexity and wide range of biological activities, such as analgesic, antihypertensive, antiarrhythmic, anti-inflammatory, antibacterial, anti-tumor, anti-cancer, and other activities, making them potential candidates for medical use. The primary objective of this review is to analyze the existing literature on the historical use of Papaveraceae plants, focusing on their alkaloid structures and relationship with pharmacological effects, as well as provide a theoretical basis for their clinical application, with the goal of unveiling the future potential of Papaveraceae plants.

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Recent advances in total synthesis of protoberberine and chiral tetrahydroberberine alkaloids

Abstract: In this comprehensive review, we categorically summarized the developmental trajectory of the total synthesis of these alkaloids based on the core closure strategies of protoberberine and tetrahydroberberine.

Cited by 2 publications

References 110 publications

Natural Product-Inspired Dopamine Receptor Ligands

Natural Product-Inspired Dopamine Receptor Ligands

Recent Advances in Alkaloids from Papaveraceae in China: Structural Characteristics and Pharmacological Effects

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