Recent Advances in Tuberculosis Diagnostic Techniques

Menon, P K; Kapila, K; Ohri, V C

doi:10.1016/s0377-1237(17)30131-4

Cited by 5 publications

(7 citation statements)

References 20 publications

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“…The sensitivity varies depending on the source of the sample. Sensitivity ranges from 46-78% and the specificity is virtually 100% [37]. Sensitivity and specificity of AFB on aspirate smear from lymph nodes in a study in our department was found to be 76.47% and 100% respectively [34].…”

Section: Necrotic Materials Onlymentioning

confidence: 72%

Nodal tuberculosis revisited: a review

Handa

Mundi

Mohan

2011

J Infect Dev Ctries

105

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Lymphadenitis is the most common extrapulmonary manifestation of tuberculosis. Tuberculous lymphadenitis is considered to be the local manifestation of the systemic disease, whereas lymphadenitis due to nontuberculous mycobacteria is truly a localized disease. A high index of suspicion is needed for the diagnosis of tuberculous lymphadenitis which is known to mimic a number of pathological conditions. Over the last two to three decades, fine needle aspiration cytology (FNAC) has emerged as a simple out-patient diagnostic procedure for the evaluation of tuberculous lymphadenitis and has replaced lymph node biopsy for histopathology. A number of molecular methods have also been introduced in diagnostics which have greatly improved the diagnostic accuracy. This article provides a review of epidemiology, clinical manifestations, and pathogenesis and emphasizes current trends in pathologic diagnosis of nodal tuberculosis.

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Section: Necrotic Materials Onlymentioning

confidence: 72%

Nodal tuberculosis revisited: a review

Handa

Mundi

Mohan

2011

J Infect Dev Ctries

105

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“…•Enzyme Linked Immunosorbent Assay (ELISA) for antigen detection (3) The detection of mycobacterial antigens in sputum, CSF and pleural and ascitic fluids can be done by using double antibody sandwich procedures of ELISA. The tests lack specificity because of the use of polyclonal antibodies.…”

Section: Development Of Interferon Gamma Releasementioning

confidence: 99%

“…Microbiological confirmation currently depends on obtaining an adequate sample for acid fast staining, culture and sensitivity. [2] An outline of tests used for identification of mycobacteria: (3) Mycobacteria are classified as category three pathogens and should be processed in biological safety cabinets ( (3) The identification of tuberculostearic acid (TBSA) in clinical samples is an alternative approach available in gas chromatography. TBSA can be detected by gas chromatography-mass spectrometry.…”

Section: Introductionmentioning

confidence: 99%

“…However, it requires special equipment and is labour intensive. Microscopy (3) The hallmark of detection is still direct microscopy of ziehl neelson stained slides and identification of cultured mycobacteria by biochemical tests. Microscopy is the easiest and quickest diagnostic test for the assessment of tuberculosis but has limited sensitivity (>10 5 bacteria/ml) and cannot identify bacterial species.…”

Section: Introductionmentioning

confidence: 99%

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A Review on Recent Advancement in Diagnosis of Tuberculosis

Fatima¹

2019

jmscr

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Objective: The main purpose of this article is to list out the most recently updated diagnostic tools for tuberculosis. Unfortunately, most of the patients are diagnosed after many weeks of infection which may lead to complications and prolongation of standard drug therapy. This might results in failure of adherence and poor health related quality of life. Sometimes, many of them are never diagnosed which results in millions of yearly death worldwide. As it is highly infectious disease, the main target should be to control the disease by developing the highly advanced diagnostic techniques for the early detection and to provide standard appropriate treatment as early as possible. This will help to reduce the transmission risk and improve the health related quality of life. Summary: Since tuberculosis has been a major challenge for the early detection of the Latent Forms of TB (LTBI) and Multi Drug Resistant TB (MDR-TB) and with the high prevalence of tuberculosis in immuno-compromised patients, there is an urgent need for the rapid development and advancement in the diagnostic tools. The sensitivity and specificity of commonly used diagnostic test is limited. Further, it is very difficult to detect the infection at early stage in case of asymptomatic tuberculosis. Inaccurate diagnostic methods results in delayed management of tuberculosis and worsening of the condition. Hence newer strategies have been introduced for the rapid detection of tuberculosis so as to give the appropriate treatment at early stage and to prevent the associated complications. Thus, this article summarizes the recent advancement introduced in the diagnostic tools for the tuberculosis. This article also covers the recent updates which have been introduced for the early diagnosis of tuberculosis.

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“…A baciloscopia apresenta como principal desvantagem a sensibilidade limitada, sendo necessários pelo menos 5.000 bacilos por mL de amostra para obter-se um resultado positivo e, além disso, requer habilidade e experiência do microscopista (Menon et al, 2000;Ganguly, 2002;Ramachadran & Paramasivan, 2003).…”

Section: Baciloscopiaunclassified

Micobactérias: Epidemiologia E Diagnóstico

Wildner

Nogueira²,

Souza³

et al. 2011

Rev Patol Trop

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Estima-se que um terço da população mundial esteja infectada com Mycobacterium tuberculosis, o que resulta em 2 milhões de mortes anualmente. No mundo, são registrados mais de 8 milhões de novos casos de tuberculose (TB) por ano e o Brasil ocupa o 19° lugar dentre os 23 países detentores da maior carga de TB. Os fatores determinantes para o controle desta doença incluem a detecção rápida, a terapia adequada e os meios para que sejam evitadas futuras transmissões. O diagnóstico convencional (baciloscopia e cultura do microrganismo) apresenta limitações quanto ao tempo de execução e à operacionalidade, visto que o resultado pode levar até 60 dias para ser liberado. Portanto, a importância da detecção precoce do bacilo se torna fundamental para o bloqueio da cadeia de transmissão da TB. Já as micobacterioses, doenças causadas pelas micobactérias não tuberculosas, também estão provocando um importante impacto em razão do aumento dos surtos de infecções cirúrgicas. A identificação rápida e específica destes microrganismos é importante para o diagnóstico e a consequente escolha do tipo de tratamento do paciente, que está diretamente relacionada com a espécie. Portanto, o conhecimento dos agentes etiológicos das doenças causadas pelas micobactérias e o diagnóstico sensível e específico permitem o tratamento adequado e, consequentemente, o bloqueio da cadeia de transmissão da TB e o controle dos surtos relacionados às micobactérias não tuberculosas. DESCRITORES: Tuberculose. Micobactérias não tuberculosas.

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Recent Advances in Tuberculosis Diagnostic Techniques

Cited by 5 publications

References 20 publications

Nodal tuberculosis revisited: a review

Nodal tuberculosis revisited: a review

A Review on Recent Advancement in Diagnosis of Tuberculosis

Micobactérias: Epidemiologia E Diagnóstico

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