Recent advances in two-photon absorbing probes based on a functionalized dipolar naphthalene platform

An, Jong Min; Kim, Sung Hyun; Kim, Dokyoung

doi:10.1039/d0ob00515k

Cited by 34 publications

(16 citation statements)

References 76 publications

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“…5f). [54][55][56] Although the TPACS values of IPNHC itself were low under the given condition; 54 GM at 730 nm, and 11 GM at 740 nm, 5 GM at 750 nm, it could be converted to IPNHC-SA complex in the biological system, which has high TPACS values. Besides, the TPACS values of IPNHC itself were sizeable in DMSO (Fig.…”

Section: In Vivo/ex Vivo Tissue Imagingmentioning

confidence: 93%

Visualizing mitochondria and mouse intestine with a fluorescent complex of a naphthalene-based dipolar dye and serum albumin

Moon

Kim

et al. 2020

J. Mater. Chem. B

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Section: In Vivo/ex Vivo Tissue Imagingmentioning

confidence: 93%

Visualizing mitochondria and mouse intestine with a fluorescent complex of a naphthalene-based dipolar dye and serum albumin

Moon

Kim

et al. 2020

J. Mater. Chem. B

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“…As a result, the photobleaching of the probes and photo-induced deterioration of the biological samples are minimized. Therefore, a wide range of TP probes is required to make TPIM a more adaptable technique in biology, medicine, and other specific applications [ 75 , 76 ].…”

Section: Potential Modes Of Copper Nanocluster Usage In Bioimagingmentioning

confidence: 99%

The Multifarious Applications of Copper Nanoclusters in Biosensing and Bioimaging and Their Translational Role in Early Disease Detection

et al. 2022

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Nanoclusters possess an ultrasmall size, amongst other favorable attributes, such as a high fluorescence and long-term colloidal stability, and consequently, they carry several advantages when applied in biological systems for use in diagnosis and therapy. Particularly, the early diagnosis of diseases may be facilitated by the right combination of bioimaging modalities and suitable probes. Amongst several metallic nanoclusters, copper nanoclusters (Cu NCs) present advantages over gold or silver NCs, owing to their several advantages, such as high yield, raw abundance, low cost, and presence as an important trace element in biological systems. Additionally, their usage in diagnostics and therapeutic modalities is emerging. As a result, the fluorescent properties of Cu NCs are exploited for use in optical imaging technology, which is the most commonly used research tool in the field of biomedicine. Optical imaging technology presents a myriad of advantages over other bioimaging technologies, which are discussed in this review, and has a promising future, particularly in early cancer diagnosis and imaging-guided treatment. Furthermore, we have consolidated, to the best of our knowledge, the recent trends and applications of copper nanoclusters (Cu NCs), a class of metal nanoclusters that have been gaining much traction as ideal bioimaging probes, in this review. The potential modes in which the Cu NCs are used for bioimaging purposes (e.g., as a fluorescence, magnetic resonance imaging (MRI), two-photon imaging probe) are firstly delineated, followed by their applications as biosensors and bioimaging probes, with a focus on disease detection.

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“…However, an interesting option to induce photoreactivity in the NIR region was represented by two-photon absorption. To this aim, authors synthesized different tetrazoles conjugated to one or two naphthalene units, characterized by welldescribed two-photon absorption properties [92]. Substrates were further functionalized with polyethylene glycol chains and carboxylic acids to improve the solubility in water.…”

Section: The Final Challenge: How To Overcome Current Limitsmentioning

confidence: 99%

Lights on 2,5-diaryl tetrazoles: applications and limits of a versatile photoclick reaction

Pirota

Benassi

Doria

2022

Photochem Photobiol Sci

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Recently, photoclick chemistry emerged as a powerful tool employed in several research fields, from medicinal chemistry and biology to material sciences. The growing interest in this type of chemical process is justified by the possibility to produce complex molecular systems using mild reaction conditions. However, the elevated spatio-temporal control offered by photoclick chemistry is highly intriguing, as it expands the range of applications. In this context, the light-triggered reaction of 2,5-diaryl tetrazoles with dipolarophiles emerged for its interesting features: excellent stability of the substrates, fast reaction kinetic, and the formation of a highly fluorescent product, fundamental for sensing applications. In the last years, 2,5-diaryl tetrazoles have been extensively employed, especially for bioorthogonal ligations, to label biomolecules and nucleic acids. In this review, we summarized recent applications of this interesting photoclick reaction, with a particular focus on biological fields. Moreover, we described the main limits that affect this system and current strategies proposed to overcome these issues. The general discussion here presented could prompt further optimization of the process and pave the way for the development of new original structures and innovative applications. Graphical abstract

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Recent advances in two-photon absorbing probes based on a functionalized dipolar naphthalene platform

Abstract: Recently reported two-photon fluorescent probes based on a functionalized dipolar naphthalene platform (FDNP) are summarized.

Cited by 34 publications

References 76 publications

Visualizing mitochondria and mouse intestine with a fluorescent complex of a naphthalene-based dipolar dye and serum albumin

Visualizing mitochondria and mouse intestine with a fluorescent complex of a naphthalene-based dipolar dye and serum albumin

The Multifarious Applications of Copper Nanoclusters in Biosensing and Bioimaging and Their Translational Role in Early Disease Detection

Lights on 2,5-diaryl tetrazoles: applications and limits of a versatile photoclick reaction

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