Recent advances in understanding, diagnosing and treating venous thrombosis

Chan, Noel; Weitz, Jeffrey I.

doi:10.12688/f1000research.27115.1

Cited by 6 publications

(8 citation statements)

References 101 publications

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“…TTR was shown to be the strongest plasma biomarker candidate for future venous thromboembolism [ 157 ]. Imbalance between coagulation and fibrinolytic systems (emphasized by local hypoxia) is the major cause of thromboembolism [ 199 ]. Hypoxia promotes pro-coagulative conditions [ 199 ].…”

Section: Ttr and Wound Healing (Fibrinolysis Vs Thrombosis)mentioning

confidence: 99%

“…Imbalance between coagulation and fibrinolytic systems (emphasized by local hypoxia) is the major cause of thromboembolism [ 199 ]. Hypoxia promotes pro-coagulative conditions [ 199 ]. Considering that TTR is upregulated under the hypoxic conditions [ 81 ], TTR upregulation may represent a protective response to thromboembolism.…”

Section: Ttr and Wound Healing (Fibrinolysis Vs Thrombosis)mentioning

confidence: 99%

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Transthyretin: From Structural Stability to Osteoarticular and Cardiovascular Diseases

Wieczorek

Ożyhar

2021

Cells

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Transthyretin (TTR) is a tetrameric protein transporting hormones in the plasma and brain, which has many other activities that have not been fully acknowledged. TTR is a positive indicator of nutrition status and is negatively correlated with inflammation. TTR is a neuroprotective and oxidative-stress-suppressing factor. The TTR structure is destabilized by mutations, oxidative modifications, aging, proteolysis, and metal cations, including Ca2+. Destabilized TTR molecules form amyloid deposits, resulting in senile and familial amyloidopathies. This review links structural stability of TTR with the environmental factors, particularly oxidative stress and Ca2+, and the processes involved in the pathogenesis of TTR-related diseases. The roles of TTR in biomineralization, calcification, and osteoarticular and cardiovascular diseases are broadly discussed. The association of TTR-related diseases and vascular and ligament tissue calcification with TTR levels and TTR structure is presented. It is indicated that unaggregated TTR and TTR amyloid are bound by vicious cycles, and that TTR may have an as yet undetermined role(s) at the crossroads of calcification, blood coagulation, and immune response.

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Section: Ttr and Wound Healing (Fibrinolysis Vs Thrombosis)mentioning

confidence: 99%

Section: Ttr and Wound Healing (Fibrinolysis Vs Thrombosis)mentioning

confidence: 99%

Transthyretin: From Structural Stability to Osteoarticular and Cardiovascular Diseases

Wieczorek

Ożyhar

2021

Cells

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“…The wrong diagnosis is problematic because failure to prescribe anticoagulant therapy to patients with VTE can enable thrombus extension and fatal PE and because inappropriate administration of anticoagulants to those without VTE can lead to fatal bleeding. Rapid and accurate diagnosis is therefore essential …”

mentioning

confidence: 99%

“… 8 Other less frequently used methods include ventilation-perfusion lung scanning that is used for the diagnosis of PE. 7 The challenge with the reliance on imaging for ruling out VTE is the high false positive rate of the current early diagnosis methods, and most patients with suspected VTE do not actually have it. The diagnosis is confirmed in only about 20 and 5%, respectively, of those with suspected DVT and PE.…”

mentioning

confidence: 99%

“…It increases the cost to health-care systems, adds the unnecessary exposure to radiation for the majority of patients with suspected PE, and has the potential for over-diagnosis of events of uncertain clinical significance, such as calf DVT and subsegmental PE. 7 This problem was overcome by combining the pre-test probability with a sensitive assay for measurement of the level of D-dimer in plasma. 9 D-dimer is a plasmin-derived breakdown product of cross-linked fibrin.…”

mentioning

confidence: 99%

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Point-of-Care Platform for Diagnosis of Venous Thrombosis by Simultaneous Detection of Thrombin Generation and D-Dimer in Human Plasma

Annese

Barrett

et al. 2022

Anal. Chem.

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Venous thromboembolism (VTE) refers to a blood clot that starts in a vein. The risk of developing VTE is highest after major surgery or a major injury, or when someone has heart failure, cancer, or infectious disease (e.g., . Without prompt treatment to break up clots and prevent more from forming, VTE can restrict or block blood flow and oxygen, which can damage the body tissue or organs. VTE can occur without any obvious signs, and imaging technologies are used. Alternatively rapid measurement of thrombin generation (TG) and D-dimer could be used to make a fast, portable, and easy-to-use diagnostic platform for VTE. Here, we have demonstrated a diagnostic sensing platform with the ability of simultaneous detection of TG and D-dimer in human plasma. Modifications were made to both the assay protocols to eliminate the need for sample dilution and incubation steps. Using a substantially reduced sample volume, the measurement results show comparable performance to the gold standard method. Our platform is able to deliver accurate and cost-effective results for both TG and D-dimer assays when using undiluted plasma in under 15 min. The assays presented are therefore a good candidate technology for use in a point-of-care platform to diagnose VTE.

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Apelin-13 as a novel diagnostic laboratory biomarker in thromboembolic disorders: a review of literature with prospective insights

Karimi,

Shirsalimi,

Sedighi

2024

Int J Emerg Med

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Thromboembolic disorders, including deep vein thrombosis (DVT) and pulmonary embolism (PE), are major global health concerns, causing significant morbidity and mortality. Early diagnosis is crucial for effective treatment and improved patient outcomes. Recent research has identified Apelin-13, a bioactive peptide in the apelin family, as a promising diagnostic biomarker for Thromboembolic disorders. Apelin-13 supports vascular health by regulating protease balance through plasminogen activator inhibitors and modulating endothelial cell function. Additionally, it plays a vital role in coagulation, with elevated levels associated with an increased risk of clot formation, suggesting its utility in predicting thrombosis risk, particularly in preoperative evaluations. Findings indicate that the Apelin-13 pathway shows significant promise as a biomarker for Thromboembolic disorders, underscoring its potential therapeutic applications and the need for further investigation. This review synthesizes current literature on thromboembolic disorders and associated laboratory biomarkers, with a particular focus on Apelin-13. It examines Apelin-13’s role in disease mechanisms, its physiological functions, and its potential as a diagnostic biomarker in thromboembolic conditions.

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Recent advances in understanding, diagnosing and treating venous thrombosis

Cited by 6 publications

References 101 publications

Transthyretin: From Structural Stability to Osteoarticular and Cardiovascular Diseases

Transthyretin: From Structural Stability to Osteoarticular and Cardiovascular Diseases

Point-of-Care Platform for Diagnosis of Venous Thrombosis by Simultaneous Detection of Thrombin Generation and D-Dimer in Human Plasma

Apelin-13 as a novel diagnostic laboratory biomarker in thromboembolic disorders: a review of literature with prospective insights

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