“…Leptin regulates glucose tolerance, insulin sensitivity, and ultimately body weight via central and peripheral mechanisms involving activation of the sympathetic nervous system, and control of food intake and energy expenditure [ 4 , 5 , 11 , 15 , 16 , 17 ]. Leptin receptors are ubiquitously expressed and its involvement extends beyond the metabolic system, especially to the reproductive [ 18 ], immune [ 19 ], bone [ 20 ] and cardiovascular system [ 11 , 15 , 21 , 22 , 23 , 24 , 25 , 26 ]. Leptin is notably a key regulator of vascular function [ 15 , 21 , 22 , 27 ].…”