Recent Advances in Understanding the Mechanisms of Elemene in Reversing Drug Resistance in Tumor Cells: A Review

Tan, Tiantian; Li, Jie; Luo, Ruhua; Wang, Rongrong; Li-yan, Yin; Mengmeng, Liu; Zeng, Yiying; Zeng, Zhigang; Xie, Tian

doi:10.3390/molecules26195792

Cited by 23 publications

(9 citation statements)

References 105 publications

(158 reference statements)

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“…Tumor cells can also transfer drug efflux pumps to promote drug resistance. P-Glycoprotein 80 , MDR-1 81 , and ATP-binding cassette subfamily B member 1 8 are drug efflux pumps that transmit multidrug resistance in prostate cancer, OC, leukemia, and osteosarcoma. The capacity of exosomes to transmit multidrug resistance from an adriamycin-resistant variant of MCF-7 to an adriamycin-sensitive variant of MCF-7 was achieved by controlling P-glycoprotein expression 82 .…”

Section: The Effect Of Exosomal Protein Cargo On Cancer Biologymentioning

confidence: 99%

The updated role of exosomal proteins in the diagnosis, prognosis, and treatment of cancer

et al. 2022

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Exosomes are vesicles encompassed by a lipid bilayer that are released by various living cells. Exosomal proteins are encapsulated within the membrane or embedded on the surface. As an important type of exosome cargo, exosomal proteins can reflect the physiological status of the parent cell and play an essential role in cell–cell communication. Exosomal proteins can regulate tumor development, including tumor-related immune regulation, microenvironment reconstruction, angiogenesis, epithelial–mesenchymal transition, metastasis, etc. The features of exosomal proteins can provide insight into exosome generation, targeting, and biological function and are potential sources of markers for cancer diagnosis, prognosis, and treatment. Here, we summarize the effects of exosomal proteins on cancer biology, the latest progress in the application of exosomal proteins in cancer diagnosis and prognosis, and the potential contribution of exosomal proteins in cancer therapeutics and vaccines.

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Section: The Effect Of Exosomal Protein Cargo On Cancer Biologymentioning

confidence: 99%

The updated role of exosomal proteins in the diagnosis, prognosis, and treatment of cancer

et al. 2022

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“…The fact that multiple factors affect the activity and expression of these transporters adds further importance to the research in this field. Modulators of P-gp activity and expression include nutritional factors such as salt intake [ 9 , 11 ], patient factors and genetic makeup [ 2 , 31 ], and the activation of various signaling pathways in cancer compared with normal cells [ 5 , 10 , 32 ]. Thus, with the help of current knowledge on the detailed domain structure of P-gp [ 15 , 17 ] and advanced in silico screening technologies [ 6 , 29 ], the search for better P-gp inhibitors shall continue to increase anticancer therapeutic efficacy and decrease patient suffering.…”

Section: Discussionmentioning

confidence: 99%

Carnosine Potentiates Doxorubicin-Induced Cytotoxicity in Resistant NCI/ADR-RES Cells by Inhibiting P-Glycoprotein—In Silico and In Vitro Evidence

Morsy

Kandeel²,

Ibrahim³

et al. 2022

Molecules

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The activity of the P-glycoprotein (P-gp) transporter encoded by the ABCB1 gene confers resistance to anticancer drugs and contributes to cancer-related mortality and morbidity. Recent studies revealed the cytotoxic effects of the endogenous dipeptide carnosine. The current study aimed to investigate the role of carnosine as a potential inhibitor of P-gp activity. We used molecular docking and molecular dynamic simulations to study the possible binding and stability of carnosine-P-gp interactions compared with verapamil. In vitro assays using doxorubicin-resistant NCI/ADR-RES cells were established to test the effects of carnosine (10–300 µM) on P-gp activity by the rhodamine-123 efflux assay and its effect on cell viability and doxorubicin-induced cytotoxicity. Verapamil (10 µM) was used as a positive control. The results showed that carnosine binding depends mainly on hydrogen bonding with GLU875, GLN946, and ALA871, with a higher average Hbond than verapamil. Carnosine showed significant but weaker than verapamil-induced rhodamine-123 accumulation. Carnosine and verapamil similarly inhibited cell viability. However, verapamil showed a more significant potentiating effect on doxorubicin-induced cytotoxicity than a weaker effect of carnosine at 300 µM. These results suggest that carnosine inhibits P-gp activity and potentiates doxorubicin-induced cytotoxicity at higher concentrations. Carnosine might be a helpful lead compound in the fight against multidrug-resistant cancers.

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“…Recent research has demonstrated that β-ELE influences exosome content, affects the expression of certain MDR-related miRNAs, and reduces the exosome-mediated transmission of drug resistance, thereby enhancing the cells’ capacity to overcome MDR ( Zhang J. et al, 2015 ). In the exosomes of multidrug-resistant gastric cancer cells, miR-1323 is significantly expressed, which encourages EMT of gastric cancer sensitive cells and enhances their capacity for invasion and migration ( Tan et al, 2021 ). The expression of Cbl-b is likewise suppressed by miR-1323, resulting in the attenuation of drug resistance in cancer cells with MDR.…”

Section: Natural Product—derived Compounds Overcome Cancer Drug Resis...mentioning

confidence: 99%

Natural products reverse cancer multidrug resistance

Zou,

Chen,

Luo

et al. 2024

Front. Pharmacol.

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Cancer stands as a prominent global cause of death. One of the key reasons why clinical tumor chemotherapy fails is multidrug resistance (MDR). In recent decades, accumulated studies have shown how Natural Product-Derived Compounds can reverse tumor MDR. Discovering novel potential modulators to reduce tumor MDR by Natural Product-Derived Compounds has become a popular research area across the globe. Numerous studies mainly focus on natural products including flavonoids, alkaloids, terpenoids, polyphenols and coumarins for their MDR modulatory activity. Natural products reverse MDR by regulating signaling pathways or the relevant expressed protein or gene. Here we perform a deep review of the previous achievements, recent advances in the development of natural products as a treatment for MDR. This review aims to provide some insights for the study of multidrug resistance of natural products.

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Recent Advances in Understanding the Mechanisms of Elemene in Reversing Drug Resistance in Tumor Cells: A Review

Cited by 23 publications

References 105 publications

The updated role of exosomal proteins in the diagnosis, prognosis, and treatment of cancer

The updated role of exosomal proteins in the diagnosis, prognosis, and treatment of cancer

Carnosine Potentiates Doxorubicin-Induced Cytotoxicity in Resistant NCI/ADR-RES Cells by Inhibiting P-Glycoprotein—In Silico and In Vitro Evidence

Natural products reverse cancer multidrug resistance

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