Recent advances in γ-C(sp3)–H bond activation of amides, aliphatic amines, sulfanilamides and amino acids

Minimização De Deslocamento De Operadores Por Meio De Agrupamento De Ferramentais Em Arranjos Físicos Posicionais

“…A formação de ligações amida está entre as mais realizadas em indústrias químicas e farmacêuticas (PROCOPIO et al, 2022). Devido à sua grande aplicação, principalmente para produção de medicamentos, diversos métodos são estudados para sua obtenção (NI et al, 2022). A preparação de amidas catalisadas por enzimas (PETCHEY; GROGAN, 2019), para desenvolvimento de amidas secundárias e terciárias, amidação fotocatalisada de ácidos carboxílicos e aminas primárias (GU et al, 2022), através da clivagem da ligação C-N e utilização de catalisadores heterogêneos (MARTÍN; CIRUJANO, 2022), para obtenção direta de amidas a partir da reação de ácidos carboxílicos com aminas, são alguns exemplos de técnicas mais atuais obtidas na literatura, para obtenção de amidas.…”

Pd(ii)-catalyzed coupling of C–H bonds of carboxamides with iodoazobenzenes toward modified azobenzenes

“…1–3 In recent years, the concept of transition metal-catalyzed direct functionalization of C–H bonds of small organic molecules has received immense attention. 4–8 The functionalization of a C–H bond of an organic compound is an ideal synthetic transformation that helps avoid the organometallic reagent preparation step. The regio- or site-selective C–H functionalization of various classes of organic compounds has been achieved with or without the help of directing groups (DGs).…”

“…The regio- or site-selective C–H functionalization of various classes of organic compounds has been achieved with or without the help of directing groups (DGs). 4–8 In particular, we have witnessed tremendous developments in the area pertaining to the Pd( ii )-catalyzed, bidentate DG-aided site-selective C–H functionalization of carboxamides. 8–10 For example, the site-selective functionalization of the β-, γ-C–H bonds of carboxylic acids has been attained by using the bidentate DG 8-aminoquinoline (8-AQ).…”

Transition‐Metal‐Catalyzed Remote C(sp3)−H Functionalization Of Carboxylic Acid And Its Derivatives

“…The most common methods employed to overcome this problem involves the use of directing groups. [57,58] Non-directed CÀ H functionalization, on the other hand, is limited primarily to heterocycles as substrates [18,21,27,29] and has limitations like narrow substrate scope, unusal reactivity, low site selectivity, etc.…”