Recent advances of the Ephrin and Eph family in cardiovascular development and pathologies

Zhu, Yuan; Su, Sheng-an; Shen, Jian; Ma, Hong; Le, Jixie; Xie, Yao; Xiang, Meixiang

doi:10.1016/j.isci.2024.110556

iScience

2024

DOI: 10.1016/j.isci.2024.110556

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Recent advances of the Ephrin and Eph family in cardiovascular development and pathologies

Yuan Zhu,

Sheng-an Su,

Jian Shen

et al.

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2024

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References 151 publications

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EphA2 in Cancer: Molecular Complexity and Therapeutic Opportunities

Toracchio,

Carrabotta,

Mancarella

et al. 2024

IJMS

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Erythropoietin-producing hepatocellular A2 (EphA2) is a member of the Eph tyrosine kinase receptor family that has been linked to various biological processes. In tumors, EphA2 overexpression is associated with noncanonical pathway activation, tumor progression, and a poor prognosis, which has emphasized its importance as a marker of malignancy. Studies on numerous cancer models have highlighted EphA2’s dual and often contradictory action, which can be attributed to EphA2′s interactions involving multiple pathways and different ligands, as well as the heterogeneity of the tumor microenvironment. In this review, we summarize the main mechanisms underlying EphA2 dysregulation in cancer, highlighting its molecular complexity. Then, we analyze therapies that have been developed over time to counteract its action. We discuss the limitations of the described approaches, emphasizing the fact that the goal of new options is high specificity without losing therapeutic efficacy. For this reason, immunotherapy or the emerging field of targeted protein degradation with proteolysis-targeting chimeras (PROTACs) may represent a promising solution that can be developed based on a deeper understanding of the molecular mechanisms sustaining EphA2 oncogenic activity.

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EphA2 in Cancer: Molecular Complexity and Therapeutic Opportunities

Toracchio,

Carrabotta,

Mancarella

et al. 2024

IJMS

View full text Add to dashboard Cite

show abstract

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Recent advances of the Ephrin and Eph family in cardiovascular development and pathologies

Cited by 1 publication

References 151 publications

EphA2 in Cancer: Molecular Complexity and Therapeutic Opportunities

EphA2 in Cancer: Molecular Complexity and Therapeutic Opportunities

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