Recent advances on biomechanical motion-driven triboelectric nanogenerators for drug delivery

Adhikary, Partho; Mahmud, M. A. Parvez; Solaiman, Tahsin; Wang, Zhong Lin

doi:10.1016/j.nantod.2022.101513

Cited by 32 publications

(16 citation statements)

References 171 publications

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“…When pressure was renewed, the reduction of the separation distance between two triboelectric materials causes a decrease of induced positive charges on the lyophilized hydrogel film surface due to compensation from the PDMS film. Consequently, the reflux of electrons from the bottom Al electrode to the top Al electrode happens to generate a reversed electrical output current ( V OC = V contacting again ) . It has been reported that the output alternating current obtained from the TENG can be converted to a direct current and be stored in commercial capacitors as a self-powered source for triggering on-demand drug release. ,, Thus, the XG3-TMAT30-STMP-based TENG can be further developed as a self-powered resource to trigger electrically responsive drug release.…”

Section: Resultsmentioning

confidence: 99%

“…27 It has been reported that the output alternating current obtained from the TENG can be converted to a direct current and be stored in commercial capacitors as a self-powered source for triggering on-demand drug release. 26,27,60 Thus, the XG3-TMAT30-STMP-based TENG can be further developed as a self-powered resource to trigger electrically responsive drug release. groups), and cell proliferation at given time points was assessed by measuring the ATP concentration of living cells based on a Lite 2.0 luminescent cell viability assay.…”

Section: Conductive and Stretchable Properties Of Long Hydrogel Fibersmentioning

confidence: 99%

“…Xanthan gum (XG) is a polyanion polysaccharide and exists in double-helix chain conformation in aqueous solution, which endows XG-based hydrogels with injectability and spinnability due to its high viscosity and thixotropy. , Additionally, electric-stimulation drug release triggered by self-powered resources has been explored to meet energy demands for wearable, implantable, or long-term drug delivery . A triboelectric nanogenerator (TENG) as an emerging nanodevice has been invented to self-power on-demand drug delivery systems and wearable electronics due to the unique superiority of its simple structure, wide material selection, and readily available material. − A TENG can harvest electric energy as a result of charge generation by contact electrification and electrostatic induction between an electron acceptor layer such as polydimethylsiloxane (PDMS) and an electron donor layer such as polyamides (e.g., nylon), proteins, and polysaccharides (e.g., cellulose) and subsequently transfer it by conductive electrodes. , We suppose that hydrogels consisting of polysaccharides and AT segments would be applied as an electron donor layer to assemble a TENG due to containing electron-donation hydroxyl and amino groups.…”

Section: Introductionmentioning

confidence: 99%

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Conductive, Injectable, and Spinnable Aniline Tetramer-Modified Polysaccharide Hydrogels for Self-Powered Electrically Responsive Drug Release

Zhang

Fan

et al. 2022

ACS Appl. Polym. Mater.

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Self-powered electrically responsive and wearable/implantable drug delivery based on conductive, injectable, and biocompatible hydrogels has emerged as a paradigm for on-demand treatment of diseases. Herein, an electroactive aniline tetramer (AT)-grafted mushroom hyperbranched polysaccharide (TM3a) was codissolved with xanthan gum (XG) and cross-linked with sodium trimetaphosphate (STMP) to fabricate conductive and injectable XG-TMAT-STMP hydrogels. The XG3-TMAT30-STMP hydrogel swollen in a simulated gastric fluid possessed a high conductivity of 23.27 ± 0.20 mS/cm. When applying a potential of 3 V, the apparent diffusion coefficient increased regardless of whether placing DXMS-loaded hydrogels between two electrodes or setting them at the anode or the cathode, indicating electrically responsive release. The extruded XG3-TMAT-STMP hydrogel fibers exhibited good conductivity and stretchablility with low a gauge factor of 1.13 (10% < ε < 50%), suggesting potential applications as bioelectrodes and wearable/implantable drug carriers. Additionally, a triboelectric nanogenerator was fabricated by applying the XG3-TMAT30-STMP hydrogel as a triboelectric material to harvest an output potential of 0.9–1.3 V, indicating feasible application as a self-powered source.

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Section: Resultsmentioning

confidence: 99%

Section: Conductive and Stretchable Properties Of Long Hydrogel Fibersmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Conductive, Injectable, and Spinnable Aniline Tetramer-Modified Polysaccharide Hydrogels for Self-Powered Electrically Responsive Drug Release

Zhang

Fan

et al. 2022

ACS Appl. Polym. Mater.

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“…Textile materials (fibers, yarns, fabrics) have been widely applied in energy harvestors and DDS platforms, however, self‐powered DDS platforms remains at the early stages of research. [ 387 ] As favorable wearable or bio‐interface carriers, textile materials with diverse geometrics and accurate capability for loading and releasing objects provides great potential to incorporate the transdermal or implantable drug delivery technologies, realizing fiber/fabric‐based DDSs with capabilities for target drug delivery as well as self‐powered drug delivery. These electrically controllable intelligent DDS platforms with good wearability and skin affinity would largely promote the development of personalized healthcare and diagnosis.…”

Section: Elastic Fibers/fabrics For Bioelectronicsmentioning

confidence: 99%

Elastic Fibers/Fabrics for Wearables and Bioelectronics

et al. 2022

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Wearables and bioelectronics rely on breathable interface devices with bioaffinity, biocompatibility, and smart functionality for interactions between beings and things and the surrounding environment. Elastic fibers/fabrics with mechanical adaptivity to various deformations and complex substrates, are promising to act as fillers, carriers, substrates, dressings, and scaffolds in the construction of biointerfaces for the human body, skins, organs, and plants, realizing functions such as energy exchange, sensing, perception, augmented virtuality, health monitoring, disease diagnosis, and intervention therapy. This review summarizes and highlights the latest breakthroughs of elastic fibers/fabrics for wearables and bioelectronics, aiming to offer insights into elasticity mechanisms, production methods, and electrical components integration strategies with fibers/fabrics, presenting a profile of elastic fibers/fabrics for energy management, sensors, e‐skins, thermal management, personal protection, wound healing, biosensing, and drug delivery. The trans‐disciplinary application of elastic fibers/fabrics from wearables to biomedicine provides important inspiration for technology transplantation and function integration to adapt different application systems. As a discussion platform, here the main challenges and possible solutions in the field are proposed, hopefully can provide guidance for promoting the development of elastic e‐textiles in consideration of the trade‐off between mechanical/electrical performance, industrial‐scale production, diverse environmental adaptivity, and multiscenario on‐spot applications.

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“…Metallic alloy compounds composed of various elements have been attracting significant attentions in the research field of electronics, sensing, catalysis, biology, green energy, and surface plasmon resonance because of their excellent characteristics compared to bimetallic structures and their monometallic counterparts with corresponding electronic heterogeneity induced by elemental selection [ 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 ]. Surface plasmon resonance belongs to a coherent effect caused by electron oscillations that come from an interface between a metal and an agent.…”

Section: Introductionmentioning

confidence: 99%

Tuning Surface Plasmonic Resonance and Surface Wettability of Au/CrN Films Using Nitrogen-Containing Gas

Wei

Tong²,

Chen

et al. 2022

Nanomaterials

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The surface plasmonic resonance, surface wettability, and related mechanical nanohardness and of face-centered-cubic (fcc) chromium nitride (CrN) films have been successfully manipulated via the simple method of tuning nitrogen-containing gas with different nitrogen-to-argon ratios, varying from 3.5 (N35), to 4.0 (N40), to 4.5 (N45), which is directly proportional to argon. All of the obtained CrN films showed that the surface wettability was due to hydrophilicity. All of the characteristics were mainly confirmed and explained by using X-ray diffraction (XRD) patterns, including plan-view and cross-section SEM images, with calculations of the average grain size performed via histograms accompanied by different preferred grain orientations. In the present work, not only the surface plasmonic resonance, but also the surface wettability and the related mechanical nanohardness of CrN films were found to be tunable via a simple method of introducing adjustable nitrogen-reactive-containing gas during the deposition process, while the authors suggest that the crystal orientation transition from the (111) to the (200) crystalline plane changed significantly with the nitrogen-containing gas. So the transition of the preferred orientation of CrN’s cubic close-packed from (111) to (200) varied at this composite, caused and found by the nitrogen-containing gas, which can be tuned by the nitrogen-to-argon ratio. The surface plasmonic resonance and photoluminescence quenching effects were coupled photon and electron oscillations, which could be observed, and which existed at the interface between the CrN and Au metals in the designed heterostructures.

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Recent advances on biomechanical motion-driven triboelectric nanogenerators for drug delivery

Cited by 32 publications

References 171 publications

Conductive, Injectable, and Spinnable Aniline Tetramer-Modified Polysaccharide Hydrogels for Self-Powered Electrically Responsive Drug Release

Conductive, Injectable, and Spinnable Aniline Tetramer-Modified Polysaccharide Hydrogels for Self-Powered Electrically Responsive Drug Release

Elastic Fibers/Fabrics for Wearables and Bioelectronics

Tuning Surface Plasmonic Resonance and Surface Wettability of Au/CrN Films Using Nitrogen-Containing Gas

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