Recent advances on copper-catalyzed asymmetric synthesis and their potential biological applications

Ahmad, Harith; Bılal, Muhammad; Maqbool, Tahir; Rasool, Nasır; Shah, Syed Adnan Alı; Zakaria, Zainul Amiruddin

doi:10.1016/j.jscs.2023.101658

Journal of Saudi Chemical Society

2023

DOI: 10.1016/j.jscs.2023.101658

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Recent advances on copper-catalyzed asymmetric synthesis and their potential biological applications

Harith Ahmad

Muhammad Bılal

Tahir Maqbool

et al.

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Cited by 3 publications

References 288 publications

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Copper‐Catalyzed (3+2) Annulation of 5‐Ethynyloxazolidine‐2,4‐diones with Benzoylacetonitriles: Synthesis of Dihydrofuran Derivatives

Du,

Qu,

et al. 2023

ChemistrySelect

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The copper‐catalyzed (3+2) annulation of 5‐ethynyloxazolidine‐2,4‐diones with acylacetonitriles worked well under mild reaction conditions to afford biologically important 2,3‐dihydrofuran derivatives having an amide moiety in moderate to high yields. A wide scope of easily accessible 5‐ethynyloxazolidine‐2,4‐diones and acylacetonitriles were tolerated. The successful scale‐up reaction demonstrated that the reaction is a useful method for the synthesis of 2,3‐dihydrofuran derivatives.

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Copper‐Catalyzed (3+2) Annulation of 5‐Ethynyloxazolidine‐2,4‐diones with Benzoylacetonitriles: Synthesis of Dihydrofuran Derivatives

Du,

Qu,

et al. 2023

ChemistrySelect

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Dinuclear Zn-Catalytic System as Brønsted Base and Lewis Acid for Enantioselectivity in Same Chiral Environment

Ayesha,

Ashraf,

Arshad

et al. 2024

ACS Omega

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Zinc (Zn) is a crucial element with remarkable significance in organic transformations. The profusion of harmless zinc salts in the Earth's outer layer qualifies zinc as a noteworthy contender for inexpensive and eco-friendly reagents and catalysts. Recently, widely recognized uses of organo-Zn compounds in the field of organic synthesis have undergone extensive expansion toward asymmetric transformations. The ProPhenol ligand, a member of the chiral nitrogenous-crown family, exhibits the spontaneous formation of a dual-metal complex when reacted with alkyl metal (R−M) reagents, e.g., ZnEt 2 . The afforded Zn complex possesses two active sites, one Lewis acid and the other Brønsted base, thereby facilitating the activation of nucleophiles and electrophiles simultaneously within the same chiral pocket. In this comprehensive analysis, we provide a thorough account of the advancement and synthetic potential of these diverse catalysts in organic synthesis, while emphasizing the reactivity and selectivities, i.e., dr and ee due to the design/structure of the ligands employed.

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Synthesis of anti-depressant molecules via metal-catalyzed reactions: a review

Kanwal,

Afzal,

Zubair

et al. 2024

RSC Adv.

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Recent advances on copper-catalyzed asymmetric synthesis and their potential biological applications

Cited by 3 publications

References 288 publications

Copper‐Catalyzed (3+2) Annulation of 5‐Ethynyloxazolidine‐2,4‐diones with Benzoylacetonitriles: Synthesis of Dihydrofuran Derivatives

Copper‐Catalyzed (3+2) Annulation of 5‐Ethynyloxazolidine‐2,4‐diones with Benzoylacetonitriles: Synthesis of Dihydrofuran Derivatives

Dinuclear Zn-Catalytic System as Brønsted Base and Lewis Acid for Enantioselectivity in Same Chiral Environment

Synthesis of anti-depressant molecules via metal-catalyzed reactions: a review

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