Recent Advances on Electrochemical Biosensing Strategies toward Universal Point‐of‐Care Systems

Dai, Yifan; Liu, Chung Chiun

doi:10.1002/ange.201901879

Cited by 72 publications

(44 citation statements)

References 150 publications

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“…Electrochemical biosensors have been widely used to detect nucleic acids, proteins, small molecular antibodies, and viruses. They are simple and cost-effective smart sensing systems for rapid, high-sensitivity detection ( Dai and Liu, 2019 ). In electrochemical sensors (EISs), the target is recognised using an antigen-antibody reaction, DNA, RNA, or peptide nucleic acid (PNAs) hybridisation or aptamers-based binding, each of which has high selectivity and sensitivity for the detection target ( Labib et al, 2016 ).…”

Section: Potential Biosensors For Point-of-care Sars-cov-2 Detectionmentioning

confidence: 99%

Detection of COVID-19: A review of the current literature and future perspectives

Liu

Wang

et al. 2020

Biosensors and Bioelectronics

350

309

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The rapid spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to the coronavirus disease 2019 (COVID-19) worldwide pandemic. This unprecedented situation has garnered worldwide attention. An effective strategy for controlling the COVID-19 pandemic is to develop highly accurate methods for the rapid identification and isolation of SARS-CoV-2 infected patients. Many companies and institutes are therefore striving to develop effective methods for the rapid detection of SARS-CoV-2 ribonucleic acid (RNA), antibodies, antigens, and the virus. In this review, we summarize the structure of the SARS-CoV-2 virus, its genome and gene expression characteristics, and the current progression of SARS-CoV-2 RNA, antibodies, antigens, and virus detection. Further, we discuss the reasons for the observed false-negative and false-positive RNA and antibody detection results in practical clinical applications. Finally, we provide a review of the biosensors which hold promising potential for point-of-care detection of COVID-19 patients. This review thereby provides general guidelines for both scientists in the biosensing research community and for those in the biosensor industry to develop a highly sensitive and accurate point-of-care COVID-19 detection system, which would be of enormous benefit for controlling the current COVID-19 pandemic.

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Section: Potential Biosensors For Point-of-care Sars-cov-2 Detectionmentioning

confidence: 99%

Detection of COVID-19: A review of the current literature and future perspectives

Liu

Wang

et al. 2020

Biosensors and Bioelectronics

350

309

View full text Add to dashboard Cite

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“…The biosensors of acoustic wave, i.e., quartz crystal microbalance (QCM), use a mass-based transducer that detects very small changes in mass and is very useful for analytes that do not have electrically conductive properties or inflorescence signals (e.g., viruses). Thinner quartz sheets may increase the QCM frequency for increased sensitivity, but the device will be mechanically unstable and fragile [ 143 , 144 , 145 ].…”

Section: Spr Applicationmentioning

confidence: 99%

2D Nanomaterial-Based Surface Plasmon Resonance Sensors for Biosensing Applications

Singh

Umar

et al. 2020

Micromachines

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The absorption and binding energy of material plays an important role with a large surface area and conductivity for the development of any sensing device. The newly grown 2D nanomaterials like black phosphorus transition metal dichalcogenides (TMDCs) or graphene have excellent properties for sensing devices’ fabrication. This paper summarizes the progress in the area of the 2D nanomaterial-based surface plasmon resonance (SPR) sensor during last decade. The paper also focuses on the structure of Kretschmann configuration, the sensing principle of SPR, its characteristic parameters, application in various fields, and some important recent works related to SPR sensors have also been discussed, based on the present and future scope of this field. The present paper provides a platform for researchers to work in the field of 2D nanomaterial-based SPR sensors.

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“…Electrochemical-based biosensors quantify the antibody concentration by measuring the current or the impedance through various electrochemical analytical methods. They provide simple, cost-effective, and accurate measurements [ 51 ]. To gain comprehensive information from the same serum sample, Plaxco’s group [ 52 ] designed a wash-free, electrochemical method for quantitative detection of multiple antibodies in unprocessed blood serum.…”

Section: Assessment Of Biological Functionsmentioning

confidence: 99%

Recent progress in the molecular imaging of therapeutic monoclonal antibodies

Zeng

Qian

2020

Journal of Pharmaceutical Analysis

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Therapeutic monoclonal antibodies have become one of the central components of the healthcare system and continuous efforts are made to bring innovative antibody therapeutics to patients in need. It is equally critical to acquire sufficient knowledge of their molecular structure and biological functions to ensure the efficacy and safety by incorporating new detection approaches since new challenges like individual differences and resistance are presented. Conventional techniques for determining antibody disposition including plasma drug concentration measurements using LC-MS or ELISA, and tissue distribution using immunohistochemistry and immunofluorescence are now complemented with molecular imaging modalities like positron emission tomography and near-infrared fluorescence imaging to obtain more dynamic information, while methods for characterization of antibody’s interaction with the target antigen as well as visualization of its cellular and intercellular behavior are still under development. Recent progress in detecting therapeutic antibodies, in particular, the development of methods suitable for illustrating the molecular dynamics, is described here.

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Recent Advances on Electrochemical Biosensing Strategies toward Universal Point‐of‐Care Systems

Cited by 72 publications

References 150 publications

Detection of COVID-19: A review of the current literature and future perspectives

Detection of COVID-19: A review of the current literature and future perspectives

2D Nanomaterial-Based Surface Plasmon Resonance Sensors for Biosensing Applications

Recent progress in the molecular imaging of therapeutic monoclonal antibodies

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