Recent advances: Urology

Abrams, Paul; Wein, Alan J.

doi:10.1136/bmj.321.7273.1393

Cited by 8 publications

(7 citation statements)

References 10 publications

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“…Results of metaanalysis studies on distribution and prevalence of urological diseases show that urolithiasis and renal infection are the most common disorders encountered in this category. When the same distribution observed in aged populations, prostate cancer, bladder cancer, lower urinary tract syndromes (generally in older men), urinary incontinence and urinary tract infections (generally in older woman) are conspicuous (3). Overall, metabolic syndromes increase the risk of urological diseases, which may evolve to end-stage renal diseases.…”

Section: Introductionmentioning

confidence: 93%

“…Poor awareness and unconscious consuming increase the probability of diseases not only in underdeveloped countries but also in developed countries. However, development of noninvasive or less invasive solutions targeting many urological conditions reduces the morbidity of procedures by replacing them (3). Robotic surgery is taking the place of traditional surgery in urological procedures as well as other procedures.…”

Section: Introductionmentioning

confidence: 99%

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Current Status of Urological Surgery Clinical Trials in the Middle East and Its Analysis in Comparison to Global

Özdener¹,

Sursal²,

Narter³

2019

jus

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To analyze the rates and types of ongoing urological surgery clinical trials (CTs) in the Middle East (ME) and worldwide. Materials and Methods: The number of urological surgery CTs was identified via the ClinicalTrials.gov database. Studies were further analyzed using different filters present in ClinicalTrials.gov. Results: Vast majority of urological surgery CTs are progressing in North America and Europe with 71.53%. The ME accounts for only 6.19%. In the ME, only Turkiye hosts studies of pediatric urological surgery. Additionally, the vast majority of adult studies were also belongs to Turkiye with 64%. Further, the large portion of conducted CTs in the ME is phase 3 studies and studies with no phase indicated. Similarly, all urological surgery CTs conducted in Turkiye are in later phases or with no phase indicated. Moreover, industry resources are not directed upon these studies in the ME. Few countries use the advantages of industry resources for conducting urological surgery CTs. Conclusion: The ME should be considered as a fertile land for adopting urological surgery CTs due to high population despite low ongoing studies. The lack of industry support in the ME is another problem, which may improve via rendering the ME more attractive for sponsors by adopting new regulatory guidelines for some of the countries.

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Section: Introductionmentioning

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Current Status of Urological Surgery Clinical Trials in the Middle East and Its Analysis in Comparison to Global

Özdener¹,

Sursal²,

Narter³

2019

jus

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“…In this process, the anatomy and physiology of the penis become normal, and the procedure has minimal complications. Hypospadias is a unique congenital pathology with hundreds of described surgical procedures, and history is replete with these surgical aspects and technical reviews [3][4][5][6][7].…”

Section: Introductionmentioning

confidence: 99%

A Comparative Study on the Outcomes of Hypospadias Surgery Following Early Versus Late Bladder Catheter Removal

Kumar¹,

Dhayal²

2022

Cureus

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BackgroundHypospadias is the most common penile malformation affecting up to one in 300 live male births. In general, a urinary diversion (urethral stent or bladder catheter) is maintained in situ for two to seven days or more after hypospadias repair. Because of the low level of evidence, the latest guidelines of the European Association of Urology and the European Society of Paediatric Urology provide no recommendations concerning the timing of catheter removal after hypospadias surgery. In this study, we aimed to compare the outcomes of hypospadias surgery (tubularized incised plate urethroplasty, TIPU) following early versus late bladder catheter removal. MethodologyIn total, 62 patients were included in this study. All patients underwent TIPU by the same team of surgeons. All patients were divided into the following two groups: group A (32 patients) had their catheter removed on or before the fifth postoperative day, and group B (30 patients) had their catheter removed after the fifth postoperative day. All patients were scheduled for an outpatient assessment after two weeks, at one month, after three months, and at six months if necessary. ResultsThe mean age of patients in group A was five years (three to seven years) and in group B was five years (four to 7.25 years) with a p-value of 0.378. Among the early complications of the surgery, the occurrence of wound infections, urinary tract infections, and urinary retention was comparable among the two groups. The rate of bladder spasms (0% versus 13.3%, p = 0.033) was significantly higher in group B than in group A. The rate of urinary retention (12.5% versus 0%, p = 0.045) was significantly higher in group A than in group B. Superficial wound infection occurred in two out of 32 patients in group A (6.3%) and two out of 30 patients in group B (6.7%) (p = 0.94). Both groups had similar incidences of wound complications. Urinary tract infections also had a similar incidence in both early and late catheter removal groups, i.e., one out of 32 patients in group A (3.1%) and three out of 30 patients (10%) in group B (p = 0.271). Urinary extravasation following hypospadias repair occurred in two out of 32 patients (6.3%). No extravasation was noted in the late catheter removal group. However, the difference was not clinically significant (p = 0.164). Two patients in both groups developed urethrocutaneous fistula (6.3% in group A versus 6.7% in group B). However, the difference was not clinically significant. Meatal stenosis developed in three out of 32 patients in group A and two out of 30 patients in group B (9.4% versus 6.7%; p = 0.696). One patient in the early catheter removal group developed urethral stricture as a late complication. None of the patients in the late catheter removal group developed this complication. ConclusionsThe occurrence of long-term complications of TIP hypospadias repair was not affected by the early removal of the bladder catheter. The shortcomings of our study were its descriptive nature and the small sample size. Further prospective r...

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“…An overactive bladder (OAB) includes urgency, frequent voiding, nocturia and urge incontinence [1] . The symptoms of an OAB often remain a therapeutic problem, despite the optimal use of conservative treatment methods, including drug therapy, behavioural therapy, pelvic floor exercises and biofeedback [2] .…”

Section: Introductionmentioning

confidence: 99%

Posterior tibial nerve stimulation as treatment for the overactive bladder

Sherif

Abdelwahab²

2013

Arab Journal of Urology

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ObjectiveTo evaluate the efficacy of posterior tibial nerve stimulation (PTNS) as a treatment for the overactive bladder (OAB) resistant to medical treatment.Patients and methodsThe study included 60 patients, comprising 55 women (92%) and five men (8%) with a mean (SD) age of 41.4 (10.8) years, who presented to the Urology Department of Benha University Hospital from June 2010 to October 2012. All patients were assessed initially by taking a history, a physical examination, urine analysis, routine laboratory investigations, and a urodynamic evaluation in the form of flowmetry, cystometry, and a pressure-flow study in some cases. A voiding diary (daytime and night-time frequency, voiding volume, and leakage episodes) was completed by all patients, and all underwent 12 sessions of PTNS using a personal computer-based system, and were reassessed after the sixth session, at the end of the course, and at 3 and 6 months after the last session, using the same methods as in the baseline visit.ResultsThere was a statistically significant improvement in all the variables assessed. No infection or failure of the PTNS mechanism was detected while using the technique, but there were rare instances of minor bleeding and a temporary painful feeling at the insertion site.ConclusionPTNS is safe, and gives statistically significant improvements in the patient’s assessment of OAB symptoms.

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Recent advances: Urology

Cited by 8 publications

References 10 publications

Current Status of Urological Surgery Clinical Trials in the Middle East and Its Analysis in Comparison to Global

Current Status of Urological Surgery Clinical Trials in the Middle East and Its Analysis in Comparison to Global

A Comparative Study on the Outcomes of Hypospadias Surgery Following Early Versus Late Bladder Catheter Removal

Posterior tibial nerve stimulation as treatment for the overactive bladder

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