Recent approaches for enhancing sensitivity in enantioseparations by CE

Sánchez‐Hernández, Laura; García‐Ruiz, Carmen; Marina, Marı́a Luisa; Crego, Antonio L.

doi:10.1002/elps.200900429

Cited by 30 publications

(21 citation statements)

References 62 publications

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“…In order to solve this problem, different approaches were used in the last years to enhance the detection sensitivity in chiral analysis of β‐blockers and structurally related compounds, such as offline sample treatment techniques, online sample preconcentration techniques, and alternative detection systems to the widely employed on‐column UV–Vis absorption detection. Online sample preconcentration techniques have been developed to enhance sensitivity in enantioseparations inside the capillary because of its simplicity, high efficiency, and cheapness . The online preconcentration techniques used in chiral CE‐UV analysis are mainly ITP, sample stacking, and sweeping.…”

Section: Online Sample Preconcentration Techniques For Improving Detementioning

confidence: 99%

Recent developments in chiral analysis of β‐blocker drugs by capillary electromigration techniques

Zhang

Chen

et al. 2014

Electrophoresis

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The latest developments in chiral analysis of β-blocker drugs by capillary electromigration techniques are reviewed in this article. Following the previous review by Aturki et al. [Electrophoresis 2011, 32, 2602-2628], this review includes the papers published during the period from January 2011 to December 2013. During this time, some novel chiral selectors were reported and applied to improve the enantioseparation of β-blocker drugs and structurally related compounds. These chiral selectors include CDs and their derivatives, macrocyclic antibiotics, tartrate complexs, the monolithic molecularly imprinted polymer, and the polymeric surfactants. In addition, this article summarizes the methodological improvements for enhancing sensitivity in chiral analysis of β-blockers and structurally related compounds by CE. The involved authors described the use of online sample preconcentration techniques to increase the detection sensitivity in the enantiomeric analysis of a broad range of samples.

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Section: Online Sample Preconcentration Techniques For Improving Detementioning

confidence: 99%

Recent developments in chiral analysis of β‐blocker drugs by capillary electromigration techniques

Zhang

Chen

et al. 2014

Electrophoresis

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“…The aim of this review is to introduce the most recent developments in the field of sensitivity enhancement in chiral CE that have been published between June 2015 and May 2017, follows previous reviews on the topic , and compliments other reviews published over this time . The purpose of the present review does not aim to be comprehensive, but to provide to the readers an updated view of the new strategies employed to improve the sensitivity of the chiral analysis by CE in the last 2 years showing interesting approaches in different fields.…”

Section: Introductionmentioning

confidence: 99%

Recent contributions for improving sensitivity in chiral CE

2017

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The flexibility and versatility of the chiral CE are unrivaled and the same instrumentation can be used to separate a diverse range of analytes, both large and small molecules, whether charged or uncharged. However, one of the disadvantages is generally thought to be the poor sensitivity of ultraviolet (UV) detection, which is the most popular among CE detectors. This review focuses on methodologies and applications regarding improvements of sensitivity in chiral CE published in the last 2 years (June 2015 until May 2017). This contribution continues to update this series of biannual reviews, first published in Electrophoresis in 2006. The main body of the review brings a survey of publications organized according to different approaches to detect a low amount of analytes, either by sample treatment procedures or by in-capillary sample preconcentration techniques, both using UV detection, or even by employing detection systems more sensitive than UV absorption, such as LIF or MS. This review provides comprehensive tables listing the new approaches in sensitive chiral CE with categorizing by the fundamental mechanism to enhance the sensitivity, which provide relevant information on the strategies employed. The concluding remarks in the final part of the review evaluate present state of art and the trends for sensitivity enhancement in chiral CE.

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“…Previously published literature has been summarized in recent reviews on the enantioseparations of pharmaceutical drugs [5][6][7] as well as drug analysis in biological samples [8][9][10]. For general reviews on chiral electromigration techniques the reader is referred to [11][12][13][14][15][16]. Moreover, monographs on chiral CE [17,18] have been published.…”

Section: Introductionmentioning

confidence: 99%

Chiral electromigration techniques in pharmaceutical and biomedical analysis

Scriba

2011

Bioanal Rev

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Capillary electromigration techniques are often considered ideal methods for enantioseparations due to their high separation selectivity and flexibility. Thus, numerous methods employing a chiral selector as pseudostationary phase in a background electrolyte have been developed and applied for the chiral analysis of drugs in bulk ware, pharmaceutical formulations and biological matrices. Furthermore, electromigration techniques have been combined with spectroscopic methods such as nuclear magnetic resonance in order to understand the complexation of analytes by chiral selectors. The present review focuses on recent developments and applications of chiral electromigration techniques in pharmaceutical and biomedical analysis including examples illustrating analyte-selector complex formation or mechanistic studies which have been published between January 2009 and July 2011. Selector-mediated chiral separations clearly dominate while no applications of capillary electrochromatography to pharmaceutical or biomedical analysis have been reported during this period of time.

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Recent approaches for enhancing sensitivity in enantioseparations by CE

Cited by 30 publications

References 62 publications

Recent developments in chiral analysis of β‐blocker drugs by capillary electromigration techniques

Recent developments in chiral analysis of β‐blocker drugs by capillary electromigration techniques

Recent contributions for improving sensitivity in chiral CE

Chiral electromigration techniques in pharmaceutical and biomedical analysis

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