2022
DOI: 10.1039/d2ob00587e
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Recent approaches for the synthesis of pyridines and (iso)quinolines using propargylic Alcohols

Abstract: Propargylic alcohols are one of the readily available and highly explored building blocks in organic synthesis. They show distinct reactivities compared to simple alcohols and/or alkynes, and hence provide diverse...

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Cited by 16 publications
(2 citation statements)
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“…Propargyl alcohols are ubiquitous building blocks in chemical synthesis, being highly valued for their widespread application as valuable synthetic intermediates or medicinally relevant molecules themselves. [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15] They participate in a diverse array of transformations, owing this to their multifunctionality, and thereby being the subject of numerous studies. Protected propargyl alcohols can be accessed via well-developed stoichiometric methods, including mainly the use of a combination of propargyl alcohol, chlorosilane and organolithium reagent (Fig.…”
Section: Introductionmentioning
confidence: 99%
“…Propargyl alcohols are ubiquitous building blocks in chemical synthesis, being highly valued for their widespread application as valuable synthetic intermediates or medicinally relevant molecules themselves. [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15] They participate in a diverse array of transformations, owing this to their multifunctionality, and thereby being the subject of numerous studies. Protected propargyl alcohols can be accessed via well-developed stoichiometric methods, including mainly the use of a combination of propargyl alcohol, chlorosilane and organolithium reagent (Fig.…”
Section: Introductionmentioning
confidence: 99%
“…Several studies have succeeded in synthesizing or functionalizing azacycle compounds. In addition, several methods of synthesis for aromatic azacycles have been reported [ 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 ]. However, these methods still have several drawbacks such as being time-consuming, requiring a high temperature, expensive additives, and/or organic solvents, and/or having low chemoselectivity properties [ 61 , 62 , 63 ].…”
Section: Introductionmentioning
confidence: 99%