Recent Approaches of Solid Dispersion: A New Concept Toward Oral Bioavailability Sabitri Bindhani* , Snehamayee Mohapatra

Abstract

Solid dispersion (SD) has been a major advanced technology in overcoming dissolution and bioavailability problem of poorly soluble compounds. Formulation of SD in water-soluble carrier has becoming more researched over the past four decades for solubility and relative bioavailability enhancement. By reduction of the size of the drug particle to the minimum level which will enhance drug wettability and ultimately bioavailability will be definitely improved. This review article elaborates recent advanced technology and characterization of SDs and also discusses the problems and their solution for the development of better formulations.

A Review on Solid Dispersion and Carriers Used Therein for Solubility Enhancement of Poorly Water Soluble Drugs

“…6 Examples of used crystalline carriers are urea and sugars. 7 In this type, thermodynamically stable crystalline solid dispersion get formed which releases the drug slowly. 6 The dissolution rate is faster in case of amorphous solid dispersions (ASDs) as compared to crystalline sold dispersions.…”

“…These contain amorphous carriers like PVP, PEG, cellulose derivatives, etc. 7 Second generation solid dispersions were found more effective than first generation solid dispersions (SD) because of their thermodynamic stability. 9 According to the physical state of drug, ASDs can be classified as amorphous solid suspensions and amorphous solid solutions [glass solutions].…”

“…8 The carrier used are either water soluble carrier or water insoluble carrier. 7 Solubility enhancement and extended release of drug in controlled manner are the two targets in CRSD. 8 The water soluble carriers used in CRSD are ethyl cellulose, Eudragit RS, Eudragit RL, HPC, etc.…”

“…8 The water soluble carriers used in CRSD are ethyl cellulose, Eudragit RS, Eudragit RL, HPC, etc. 7 On the basis of physical state and molecular arrangement of active pharmaceutical ingredient (API) and carrier, binary solid dispersions can be divided into six distinct systems as follows:…”

“… 8 The water soluble carriers used in CRSD are ethyl cellulose, Eudragit RS, Eudragit RL, HPC, etc. 7 …”