Recent case studies on the use of ozone to combat coronavirus: Problems and perspectives

Manjunath, Soumya Nagashri; Sakar, M.; Katapadi, Manmohan; Balakrishna, R. Geetha

doi:10.1016/j.eti.2020.101313

Cited by 30 publications

(18 citation statements)

References 34 publications

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“…In a recent review article, Fernández-Cuadros et al reported that O3 could be beneficial for the management of COVID-19 disease, due to its virucidal, immunomodulatory properties, as well as its ability to facilitate oxygen transport to hypoxemic tissues [ 6 ]. Interestingly, Manjunath et al have investigated recent case reports on the use of O3 to combat coronavirus, and concluded that it could be advantageous in combating coronaviruses in the human body as well as in the environment [ 7 ]. The effectiveness of rectal O3 insufflation was evaluated in a recent study that included four patients with severe COVID-19 pneumonia.…”

Section: Introductionmentioning

confidence: 99%

Old Treatment for a New Disease: Can Rectal Ozone Insufflation Be Used for COVID-19 Management? A Case Report

Hendawy

Mosallam

Abuelnaga

et al. 2021

SN Compr. Clin. Med.

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COVID-19 is a newly discovered deadly disease with no proven definitive treatment until now. It is now proved that it can affect different body organs which necessitate intensive care management. Ozone (O3) therapy was used before for treating various viral infections like hepatitis B, human immune deficiency virus (HIV), and Ebola viruses. O3 also can manage hypoxia and increase tissue oxygenation, besides its anti-inflammatory and immunomodulatory properties which may have an important role in the management of cytokine storm. We used rectal O3 insufflation therapy assuming that it may have a beneficial role in the management of COVID-19 disease. Two sessions of rectal O3 therapy were given to a 60-year-old female patient who was confirmed COVID-19 positive. Before applying O3 therapy, she was hypoxic (sPO2:90%) despite mechanical ventilation with high fraction inspired oxygen (FiO2:90%). After therapy, she was markedly improved and discharged to the inpatient ward and then discharged home on day 10 post-admission. Another 40-year-old male patient who was confirmed COVID-19 positive and was home isolated received one session of O3 therapy. Before therapy, he was hypoxic (sPO2:85% on room air and 95% with O2 face mask 5 L/min). The patient showed gradual improvement over the next 3 days after therapy and becomes oxygen-independent (sPO2 became 94–97% on room air). No adverse effects were noticed in both cases. Rectal O3 insufflation can be used safely as adjuvant management for patients with COVID-19 disease.

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Section: Introductionmentioning

confidence: 99%

Old Treatment for a New Disease: Can Rectal Ozone Insufflation Be Used for COVID-19 Management? A Case Report

Hendawy

Mosallam

Abuelnaga

et al. 2021

SN Compr. Clin. Med.

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“…The S2 subunit is further cleaved and primed by transmembrane serine protease 2 (TMPRSS2), a serine protease on the surface of host cells, resulting in the fusion of the viral envelope with the host cell membrane (Hoffmann et al, 2020 ). Recently, ozone was proposed to act on the S protein of coronavirus, preventing membrane fusion with host cells (Manjunath et al, 2021 ).…”

Section: Discussionmentioning

confidence: 99%

Inactivation of SARS-CoV-2 by Ozonated Glycerol

et al. 2021

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We evaluated the SARS-CoV-2-inactivation activity of ozonated glycerol (OG). When a viral solution with 1% fetal bovine serum (FBS) was mixed with test solutions at a ratio of 1:19 and incubated for 20 s, OG with ozone concentrations of over 1000 ppm inactivated ≥ 94.38% of the virus. Extension of the reaction time to 1 h led to the inactivation of ≥ 99.82% of the virus (the viral titer was below the detection limit). Extension to 24 h resulted in concentrations over 200 ppm OG inactivating ≥ 99.87% of the virus (the viral titers were below the detection limit). Next, viral solutions with 1, 20, and 40% FBS were mixed with test solutions at a ratio of 1:19 and incubated for 5 min. Whereas the virucidal activity of 500 ppm OG was very limited in the presence of 1% FBS (79.47% inactivation), it increased in the presence of 20 and 40% FBS (95.13 and 97.95% inactivation, respectively; the viral titers were not below the detection limit). Meanwhile, over 1000 ppm OG inactivated ≥ 99.44% of the virus regardless of the FBS concentration (the viral titers were below the detection limit). Extension of the reaction time to 1 h led to 500 ppm OG inactivating ≥ 99.91 and ≥ 99.95% of the virus with 20 and 40% FBS, respectively (the viral titers were below the detection limit). These results suggested that OG might be useful as a virucidal agent against SARS-CoV-2.

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“…These viruses, being RNA viruses, are found to be susceptible to ozone. Ozone being an unstable molecule can break up into its split products, namely reactive oxygen species and ozonides, creating a toxic environment for these viruses [112][113][114]. Some authors (Mazur-Panasiuk et al 2021) [115] are skeptical about the effectiveness of this method for food transport.…”

Section: Management Of Temperature In the Fcc Augmented With Spcmentioning

confidence: 99%

Economic Impact of Temperature Control during Food Transportation—A COVID-19 Perspective

Skawińska

Zalewski

2022

Foods

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Temperature fluctuation and abuse in the food cold chain (FCC) is becoming an increasingly crucial factor in the process of food production and for the logistic business, especially in COVID-19 pandemic. The quality of perishable food products depends largely on accurate transport and maintenance temperature. The evidence for temperature-related food waste and loss is extensive. The research problem is thus: how to decrease and control food losses caused by temperature abuse in the FCC and restrictions due to the COVID-19 pandemic. The primary objective is to propose a framework for real-time temperature measurement protocols supported by passive RFID, IoT and Statistical Process Control (SPC) charts. This method allows not only the signaling of temperature abuse alerts but, in addition to hitherto methods, investigation and mitigation of the causes of process instability of individual FCC links in the future. The secondary objective is to delineate the necessary data sources and ways of their collection and utilization in order to decrease food losses and waste via process stabilization of temperature in transport and storage. As contribution to current literature and practice, we offer an in-depth analysis of threats in the FCC in food transport and storage infrastructure and a solution supplemented by SPC charts and tested in controlled experiments that is practicable from economic and technical standpoints.

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Recent case studies on the use of ozone to combat coronavirus: Problems and perspectives

Cited by 30 publications

References 34 publications

Old Treatment for a New Disease: Can Rectal Ozone Insufflation Be Used for COVID-19 Management? A Case Report

Old Treatment for a New Disease: Can Rectal Ozone Insufflation Be Used for COVID-19 Management? A Case Report

Inactivation of SARS-CoV-2 by Ozonated Glycerol

Economic Impact of Temperature Control during Food Transportation—A COVID-19 Perspective

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