Recent Development in the Chemistry of Pyrido-oxazines, Pyrido-thiazines, Pyrido-diazines and Their Benzologs: Part 1

Synthesis and antimicrobial activity of morpholinyl/piperazinylbenzothiazines

“…1,4-Benzothiazines are also known for their applications as anticancer (Ma et al, 1998;Mahmoud et al, 2005;Matysiak, 2006), antifungal (Macchiarulo et al, 2002, Fringuelli et al, 2001, cardiovascular (Hermecz, 2003), antibacterial (Selvakumar et al, 2006), antimicrobial (Rosato, 2006) and anti-anginal (Kanda and Hashimoto, 1993) drugs. Therefore morpholine, piperazine and 1,4-benzothiazine heterosystems have been considered as important pharmacophores for incorporation of design, and synthesize biologically active molecules particularly effective for central nervous system and cardiovascular system related disorders.…”

Recent Advances in the Area of Pyridodiazinium Systems Containing Bridgehead-Nitrogen Atom

“…Earlier some extended and thorough review articles on these *Address correspondence to this author at the Institute of Biomolecular Chemistry, Chemical Research Center, Hungarian Academy of Sciences, H-1025 Budapest, Pusztaszeri út 59-67, Hungary; Tel: +36-13257550; Fax: +36-13257865; E-mail: ghajos@chemres.hu and other oxa and thio analogues appeared. Thus, detailed history of chemistry of the title compounds can be found for the following ring systems: pyrido[1,2-a]pyrimidinium (b, [1,2,3]), pyrido [1,2-a]pyrazinium (c, [1,2,4]), pyrido [1,2-c]pyrimidinium (d, [1,2,5]) and pyrido [1,2-b]pyridazinium salts (e, [1,2,6]). These surveys reveal that in many cases relatively much attention has been paid to partly saturated derivatives of these cations which may have two main reasons: (i) the heteroaromatic cationic species are reactive enough in many cases to undergo transformations in which the aromatic character has been lost, (ii) some partly saturated derivatives (e.g.…”