Recent development of cationic cyclodextrins for chiral separation

Zhou, Jie; Tang, Jian; Tang, Weihua

doi:10.1016/j.trac.2014.10.009

Cited by 90 publications

(66 citation statements)

References 49 publications

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“…A huge variety of chiral selectors are employed in CE, being CDs the most frequently used due to their commercial availability, universality, and low toxicity as shown in recent reviews . Other chiral selectors include surfactants, antibiotics, crown ethers, proteins, and ligand‐exchange compounds .…”

Section: Introductionmentioning

confidence: 99%

Improving the sensitivity in chiral capillary electrophoresis

2015

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CE is known for being one of the most powerful analytical techniques when performing enantioseparations due to its numerous advantages such as excellent separation efficiency and extremely low solvents and reagents consumption, all of them derived from the capillary small dimensions. Moreover, it is worth highlighting that unlike in chromatographic techniques, in CE the chiral selector is generally within the separation medium instead of being attached to the separation column which makes the method optimization a more versatile task. Despite its numerous advantages, when using UV-Vis detection, CE lacks of sensitivity detection due to its short optical path length derived from the narrow separation capillary. This issue can be overcome by means of different approaches, either by sample treatment procedures or by in-capillary preconcentration techniques or even by employing detection systems more sensitive than UV-Vis, such as LIF or MS. The present review assembles the latest contributions regarding improvements of sensitivity in chiral CE published from June 2013 until May 2015, which follows the works included in a previous review reported by Sánchez-Hernández et al. [Electrophoresis 2014, 35, 12-27].

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Section: Introductionmentioning

confidence: 99%

Improving the sensitivity in chiral capillary electrophoresis

2015

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“…The direct synthesis of other single-isomer derivatives is more difficult, due to the number of theoretically possible isomers. Monosubstituted derivatives are used in catalysis, [38][39][40][41] separation techniques, [35,[42][43][44] biomedical applications, [45][46][47] nanotechnologies [37,48] and sensors, [49] or as components of supramolecular assemblies. However, scientists have been devoting great efforts to add more than one functional group to a CD skeleton.…”

Section: General Methods For Synthesis and Characterisation Of Monosumentioning

confidence: 99%

Monosubstituted Cyclodextrins as Precursors for Further Use

Řezanka

2016

Eur J Org Chem

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Cyclodextrin derivatives find use in a broad field of applications (e.g., nanomaterials, biomedical applications, catalysis, separation techniques, sensors etc.), with monosubstitution allowing cyclodextrins to be attached to various types of surfaces or for a new feature to be introduced onto a cyclodextrin skeleton (recognition, catalysis, …). Although an enormous number of monosubstituted cyclodextrin derivatives have been synthesised, this review focuses only on the synthesis of several interesting monosubstituted derivatives (allyl, cinnamyl, propargyl, formylmethyl, carboxymethyl, azido and amino) suitable for further modifications. These derivatives allow the synthesis of an unlimited number of desired cyclodextrin derivatives. Using a cyclodextrin derivative already monosubstituted with a suitable functional group is much easier than the optimisation of monosubstitution for every new cyclodextrin derivative desired.

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“…LC can be considered the method of choice in analytical laboratories due to its high speed, sensitivity, and reproducibility. Moreover, a number of CSPs based on polysaccharide derivatives, macrocyclic antibiotics, small chiral molecules, cyclodextrins, crown ethers, proteins, synthetic polymers, molecularly imprinted polymers, among others, have been developed for successful enantioseparations . However, in spite of a large number of different types of CSPs described for enantiomeric separation by LC, there is no universal CSP, i.e., one CSP can only separate a limited number of chiral compounds and, in many cases, the choice of CSP may became a difficult task.…”

Section: Introductionmentioning

confidence: 99%

New chiral stationary phases based on xanthone derivatives for liquid chromatography

Fernandes¹,

Tiritan²,

Cravo³

et al. 2017

Chirality

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Six chiral derivatives of xanthones (CDXs) were covalently bonded to silica, yielding the corresponding xanthonic chiral stationary phases (XCSPs). The new XCSPs were packed into stainless-steel columns with 150 x 4.6 mm i.d. Moreover, the greening of the chromatographic analysis by reducing the internal diameter (150 x 2.1 mm i.d.) of the liquid chromatography (LC) columns was also investigated. The enantioselective capability of these phases was evaluated by LC using different chemical classes of chiral compounds, including several types of drugs. A library of CDXs was evaluated in order to explore the principle of reciprocity as well as the chiral self-recognition phenomenon. The separation of enantiomeric mixtures of CDXs was investigated under multimodal elution conditions. The XCSPs provided high specificity for the enantiomeric mixtures of CDXs evaluated mainly under normal-phase elution conditions. Furthermore, two XCSPs were prepared with both enantiomers of the same xanthonic selector in order to confirm the inversion order elution.

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Recent development of cationic cyclodextrins for chiral separation

Cited by 90 publications

References 49 publications

Improving the sensitivity in chiral capillary electrophoresis

Improving the sensitivity in chiral capillary electrophoresis

Monosubstituted Cyclodextrins as Precursors for Further Use

New chiral stationary phases based on xanthone derivatives for liquid chromatography

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