Recent developments in antimalarial drug discovery

Umumararungu, Théoneste; Nkuranga, Jean Bosco; Habarurema, Gratien; Nyandwi, Jean Baptiste; Mukazayire, Marie Jeanne; Mukiza, Janvier; Muganga, Raymond; Hahirwa, Innocent; Mpenda, Matabishi; Katembezi, Alain Nyirimigabo; Olawode, Emmanuel Oladayo; Kayitare, Egide; Kayumba, Pierre Claver

doi:10.1016/j.bmc.2023.117339

Cited by 9 publications

(4 citation statements)

References 274 publications

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“…Although for some of these drugs the mechanism of action remains unknown, some are proposed to interfere with signal transduction pathways by inhibiting enzymes such as phosphatidylinositol 4-kinase (PI4K). Some are hypothesized to inhibit lipid storage and vesicular trafficking pathways [ 49 ].…”

Section: How Computational Tools Have Helped Curb Malariamentioning

confidence: 99%

Leveraging computational tools to combat malaria: assessment and development of new therapeutics

Ncube,

Tukulula,

Govender

2024

J Cheminform

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As the world grapples with the relentless challenges posed by diseases like malaria, the advent of sophisticated computational tools has emerged as a beacon of hope in the quest for effective treatments. In this study we delve into the strategies behind computational tools encompassing virtual screening, molecular docking, artificial intelligence (AI), and machine learning (ML). We assess their effectiveness and contribution to the progress of malaria treatment. The convergence of these computational strategies, coupled with the ever-increasing power of computing systems, has ushered in a new era of drug discovery, holding immense promise for the eradication of malaria. Scientific contribution Computational tools remain pivotal in drug design and development. They provide a platform for researchers to explore various treatment options and save both time and money in the drug development pipeline. It is imperative to assess computational techniques and monitor their effectiveness in disease control. In this study we examine renown computational tools that have been employed in the battle against malaria, the benefits and challenges these tools have presented, and the potential they hold in the future eradication of the disease.

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Section: How Computational Tools Have Helped Curb Malariamentioning

confidence: 99%

Leveraging computational tools to combat malaria: assessment and development of new therapeutics

Ncube,

Tukulula,

Govender

2024

J Cheminform

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“…MMV provides guidelines to reduce the incidence and hazards of malaria. Also, TCPs 1–6 offer guidelines on the mechanisms of action of malaria drug candidates, while TPPs 1–2 concentrate mostly on the management procedures that are crucial for treating malaria [12] . One of the novel strategies developed against malaria is the use of transition metal complexes.…”

Section: Introductionmentioning

confidence: 99%

“…Also, TCPs 1-6 offer guidelines on the mechanisms of action of malaria drug candidates, while TPPs 1-2 concentrate mostly on the management procedures that are crucial for treating malaria. [12] One of the novel strategies developed against malaria is the use of transition metal complexes. An illustration of this is the anti-arthritic gold medication auranofin, which exhibits anti-plasmodial action by causing severe oxidative stress via thioredoxin reductase inhibition.…”

Section: Introductionmentioning

confidence: 99%

Biannual Account of Anti‐malarial Agents reported in 2021 and 2022: A Comprehensive Coverage

Dhameliya,

Patel,

Kathuria

et al. 2024

ChemistrySelect

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Malaria remains a severe infectious disease caused by Plasmodium parasites among the primarily afflicting impoverished populations. According to World Health Organization (WHO) report, there were an estimated 247 million malarial cases globally, resulting in approximately 6,19,000 fatalities. Particularly prevalent in tropical and subtropical regions, the development of drug resistance has exacerbated this public health challenge. Consequently, there has been a concrete effort to explore novel compounds with anti‐malarial properties. In continuation of our previous works, this review focuses on heterocyclic compounds documented in 2021 and 2022, including artemisinin, benzimidazole, benzofuran, β‐lactam, coumarin, furan, indole, morpholine, piperazine, pyrimidine, quinoline, triazole, etc. highlighting their efficacy, structural characteristics, in vitro and in vivo activities, among other relevant aspects for the broad interest of medicinal chemists working on the design and development of novel anti‐malarial agents.

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“…Tragically, children under the age of five bear the brunt of this disease, accounting for 76 % of all malaria-related deaths globally. Human malaria is caused by five species of the Plasmodium parasite, with Plasmodium falciparum and P. vivax being the most prevalent in Africa and countries outside of Africa, respectively ( Umumararungu et al, 2023 ). Despite the continuing effort to eradicate malaria, there is an increase in its resistance to the most effective drugs such as artemisinin, mefloquine, and piperaquine leading to the use of artemisinin-based combination therapies (ACTs) ( Lin et al, 2023 ; Mishra et al, 2023 ).…”

Section: Introductionmentioning

confidence: 99%

Structure-based design, and development of amidinyl, amidoximyl and hydroxamic acid based organic molecules as novel antimalarial drug candidates

Adebayo,

Oduselu,

Aderohunmu

et al. 2024

Arabian Journal of Chemistry

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Recent developments in antimalarial drug discovery

Cited by 9 publications

References 274 publications

Leveraging computational tools to combat malaria: assessment and development of new therapeutics

Leveraging computational tools to combat malaria: assessment and development of new therapeutics

Biannual Account of Anti‐malarial Agents reported in 2021 and 2022: A Comprehensive Coverage

Structure-based design, and development of amidinyl, amidoximyl and hydroxamic acid based organic molecules as novel antimalarial drug candidates

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