Recent developments in cancer therapy and diagnosis

Gündoğdu, Evren; İlem-Özdemir, Derya; Ekinci, Meliha; Özgenç, Emre; Demir, Emine; Sánchez-Dengra, Bárbara; González‐Álvarez, Isabel

doi:10.1007/s40005-020-00473-0

Cited by 37 publications

(15 citation statements)

References 60 publications

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“…It was even reported that, without sufficient blood supply, a tumor may not be able to increase beyond 2–3 mm in diameter [ 48 ]. Apart from tumor growth, angiogenesis also endows tumor cells with a favorable environment to spread out through the bloodstream, which leads to metastasis [ 49 ]. Due to this significant contribution to the development of tumors, angiogenesis has been one of the major targets of cancer chemotherapy.…”

Section: Resultsmentioning

confidence: 99%

BSA-Silver Nanoparticles: A Potential Multimodal Therapeutics for Conventional and Photothermal Treatment of Skin Cancer

et al. 2021

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Silver nanoparticles (NPs) have attracted a considerable interest in the field of cancer research due to their potential utility in cancer therapy. In the present study, we developed bovine serum albumin (BSA)-coated silver NPs (BSA-Silver NPs) and characterized in vitro multimodal therapeutic activities of NPs for the treatment of skin cancer. BSA-Silver NPs were synthesized by a single-step reduction process, and the successful preparation was verified through a list of physical characterizations, including transmission electron microscopy (TEM), ultraviolet-visible (UV–VIS) light spectroscopy, dynamic light scattering (DLS), and Fourier transform infrared (FT-IR) spectroscopy. The synthesized BSA-Silver NPs showed marked cytocidal effects on B16F10 melanoma cells, which was likely caused by oxidative stress. BSA-Silver NPs also elicited significant anti-angiogenic effects on HUVEC (human umbilical vein endothelial cell) by inhibiting their proliferation, migration, and tube formation. Moreover, BSA-Silver NPs showed a considerable light-to-heat conversion ability, suggesting their utility as photothermal agents. Overall, our findings suggest that BSA-Silver NPs may be promising candidates for the multimodal therapy of skin cancer.

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Section: Resultsmentioning

confidence: 99%

BSA-Silver Nanoparticles: A Potential Multimodal Therapeutics for Conventional and Photothermal Treatment of Skin Cancer

et al. 2021

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“…However, these methods have the disadvantages of low efficacy, high cost, and adverse effects. [194] In order to overcome these obstacles, a minimally invasive cancer treatment related to MNs has attracted the attention of researchers. [195] The incidence rate of top 10 cancer in 2020 is shown in Figure 10.…”

Section: Cancermentioning

confidence: 99%

Recent Advances in Polymer Microneedles for Drug Transdermal Delivery: Design Strategies and Applications

Wang

Jiang

Aharodnikau

et al. 2022

Macromol. Rapid Commun.

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In recent years, transdermal drug delivery based on microneedles (MNs) technology has received extensive attention, which offers a safer and painless alternative to hypodermic needle injections. They can pierce the stratum corneum and deliver drugs to the epidermis and dermis-structures of skin, showing prominent properties such as minimally invasiveness, bypassing first-pass metabolism, and can be self-administered. A range of materials has been used to fabricate MNs, such as silicon, metal, glass, and polymers. Among them, polymer MNs have gained increasing attention from pharmaceutical and cosmetic companies as one of the promising drug delivery methods. MN products have recently become available on the market, and some of them are under evaluation for efficacy and safety. This paper focuses on the current state of polymer MNs in drug transdermal delivery. The materials and methods for the fabrication of polymer MNs and their drug administration are described. The recent progress of polymer MNs for treatment of cancer, vaccine delivery, blood glucose regulation, androgenetic alopecia, obesity, tissue healing, myocardial infarction, and gout are reviewed. The challenges of MNs technology are summarized and the future development trend of MNs is also prospected.

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“…Photo-based nanomedicines fabricated with polymers have been prepared by loading PSAs in the hydrophobic block or conjugating PSAs to the polymer backbone. After IV injection, PSAs incorporating nanomedicines can circulate systemically and accumulate in tumor tissues via the EPR effect [ 157 ]. The nanomedicines delivered to the target sites enable the capture of an image or reveal the cytotoxicity induced by irradiation because of the adequate light for PSAs.…”

Section: Polymer-based Photosensitive Nanomedicinementioning

confidence: 99%

Photo-Based Nanomedicines Using Polymeric Systems in the Field of Cancer Imaging and Therapy

et al. 2020

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The use of photo-based nanomedicine in imaging and therapy has grown rapidly. The property of light in converting its energy into different forms has been exploited in the fields of optical imaging (OI) and phototherapy (PT) for diagnostic and therapeutic applications. The development of nanotechnology offers numerous advantages to overcome the challenges of OI and PT. Accordingly, in this review, we shed light on common photosensitive agents (PSAs) used in OI and PT; these include fluorescent and bioluminescent PSAs for OI or PT agents for photodynamic therapy (PDT) and photothermal therapy (PTT). We also describe photo-based nanotechnology systems that can be used in photo-based diagnostics and therapies by using various polymeric systems.

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Recent developments in cancer therapy and diagnosis

Cited by 37 publications

References 60 publications

BSA-Silver Nanoparticles: A Potential Multimodal Therapeutics for Conventional and Photothermal Treatment of Skin Cancer

BSA-Silver Nanoparticles: A Potential Multimodal Therapeutics for Conventional and Photothermal Treatment of Skin Cancer

Recent Advances in Polymer Microneedles for Drug Transdermal Delivery: Design Strategies and Applications

Photo-Based Nanomedicines Using Polymeric Systems in the Field of Cancer Imaging and Therapy

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