Recent developments in hepatopancreatobiliary EUS

Cazacu, Irina M.; Singh, Ben S.; Săftoiu, Adrian; Bhutani, Manoop S.

doi:10.4103/eus.eus_20_19

Cited by 16 publications

(7 citation statements)

References 16 publications

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“…Hepatobiliary-pancreatic (HBP) cancer includes liver cancer, biliary tract cancer, gallbladder cancer and pancreatic cancer[ 1 - 3 ]. The number of new cases of HBP cancer worldwide in 2018 was approximately 1.85 million, accounting for 10% of all newly diagnosed cancer cases and resulting in a great financial burden[ 4 , 5 ].…”

Section: Introductionmentioning

confidence: 99%

Associations between serum uric acid and hepatobiliary-pancreatic cancer: A cohort study

Huang

et al. 2020

WJG

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BACKGROUND Uric acid is the end product of purine metabolism. Previous studies have found that serum uric acid (SUA) levels are associated with the total cancer risk. However, due to the dual effect of uric acid on cancer, the relationship between the SUA levels and most specific-site cancer remains unclear. AIM To investigate the associations between the SUA levels and incidence of hepatobiliary-pancreatic cancer. METHODS In this prospective cohort study, 444462 participants free of cancer from the UK Biobank were included. The SUA levels were measured at baseline, and the incidence of hepatobiliary-pancreatic cancer was determined by contacting the cancer registry. The hazard ratios (HRs) and 95% confidence intervals (CIs) between the SUA levels and hepatobiliary-pancreatic cancer were investigated using multiple adjusted Cox regression models adjusted for potential confounders. RESULTS In total, 920 participants developed liver, gallbladder, biliary tract or pancreatic cancer during a median of 6.6 yrs of follow-up. We found that the HR of pancreatic cancer in the highest SUA group was 1.77 (95%CI: 1.29-2.42) compared with that in the lowest group. After stratifying by gender, we further found that SUA was associated with an increased risk of pancreatic cancer only among the females (highest quartile vs lowest quartile HR 2.04, 95%CI: 1.35-3.08). Among the males, the SUA levels were positively associated with the gallbladder cancer risk (highest quartile vs lowest quartile HR 3.09, 95%CI: 1.28-7.46), but a U-shaped association with the liver cancer risk was observed ( P -nonlinear = 0.03). CONCLUSION SUA is likely to have gender-specific effects on hepatobiliary-pancreatic cancer. High SUA levels are a risk factor for pancreatic cancer in females and gallbladder cancer in males. A U-shaped association with the liver cancer risk was identified.

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Section: Introductionmentioning

confidence: 99%

Associations between serum uric acid and hepatobiliary-pancreatic cancer: A cohort study

Huang

et al. 2020

WJG

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“…The family in this case was definitively diagnosed with type 2 HHT, based on the Curacao standard[ 7 , 8 ]. This diagnosis relied on blood sample analysis of the proband and some relatives, which indicated the presence of an ACVRL1 mutation (c. 1232G>A, p. Arg411Gln) in the family, a history of epistaxis, and presence of capillary dilation of skin and mucosa, and AVM in the liver[ 9 ].…”

Section: Discussionmentioning

confidence: 99%

Pulmonary arterial hyper-tension in a patient with hereditary hemorrhagic telangiectasia and family gene analysis: A case report

Yuan

Wang

et al. 2021

WJCC

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BACKGROUND Hereditary hemorrhagic telangiectasia (HHT) is a rare autosomal dominant genetic disease. Very few patients suffering from HHT present with associated pulmonary arterial hypertension (PAH), which may result in a poor prognosis. Here, we report a case of HHT with PAH. The patient’s clinical manifestations and treatment as well as genetic analysis of family members are reviewed, in order to raise awareness of this multimorbidity. CASE SUMMARY A 45-year-old Chinese woman was admitted to the hospital to address a complaint of intermittent shortness of breath, which had lasted over the past 2 years. She also had a 30-year history of recurrent epistaxis and 5-year history of anemia. She reported that the shortness of breath had aggravated gradually over the 2 years. Physical examination discovered anemia and detected gallop rhythm in the precordium. Chest computerized tomography and cardiac ultrasound demonstrated PAH and hepatic arteriovenous malformation. The formal clinical diagnosis was HHT combined with PAH. The patient was treated with ambrisentan and her condition improved for a time. She died half a year after the diagnosis. Genetic testing revealed the patient and some family members to carry an activin A receptor-like type 1 mutation (c. 1232G>A, p. Arg411Gln); the family was thus identified as an HHT family. CONCLUSION We report a novel gene mutation (c. 1232G>A, p. Arg411Gln) in a Chinese HHT patient with PAH.

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“…Pancreatic cancer is most commonly diagnosed via initial CT imaging; equivocal imaging results can often be clarified with EUS-FNA, which has been shown to have sensitivity and specificity greater than 90% [ 73 ]. Studies comparing EUS-FNA to cross-sectional imaging found that the former is especially accurate for diagnosing smaller pancreatic masses (<2 cm) [ 15 , 73 ].…”

Section: Diagnosis and Stagingmentioning

confidence: 99%

“…Additionally, the function of EUS in visualizing and sampling the gastrointestinal wall layers, peri-intestinal lymph nodes, and surrounding structures gives it a crucial role in locoregional staging of malignancies [ 9 , 13 , 14 ]. Finally, there is an ever-growing therapeutic role for EUS, from supplementing ERCP in stent placement for malignant obstruction, to delivering anti-tumor agents via fine needle injection (FNI) in pancreatic cancer [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

Role of Endoscopy in Management of Upper Gastrointestinal Cancers

et al. 2022

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Upper gastrointestinal (GI) malignancy is a leading cause of cancer-related morbidity and mortality. Upper endoscopy has an established role in diagnosing and staging upper GI cancers, screening for pre-malignant lesions, and providing palliation in cases of advanced malignancy. New advances in endoscopic techniques and technology have improved diagnostic accuracy and increased the therapeutic potential of upper endoscopy. We aim to describe the different types of endoscopic technology used in cancer diagnosis, summarize the current guidelines for endoscopic diagnosis and treatment of malignant and pre-malignant lesions, and explore new potential roles for endoscopy in cancer therapy.

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Recent developments in hepatopancreatobiliary EUS

Cited by 16 publications

References 16 publications

Associations between serum uric acid and hepatobiliary-pancreatic cancer: A cohort study

Associations between serum uric acid and hepatobiliary-pancreatic cancer: A cohort study

Pulmonary arterial hyper-tension in a patient with hereditary hemorrhagic telangiectasia and family gene analysis: A case report

Role of Endoscopy in Management of Upper Gastrointestinal Cancers

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