Recent Developments in Insect Neurohormones

Raabe, Marie

doi:10.1007/978-1-4613-0805-8

Cited by 101 publications

(69 citation statements)

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“…The median nerves from abdominal ganglia 2 and 3 showed RFamide-like immunoreactivity, but this was not consistent for the other abdominal ganglia. However, tracing the transverse nerves from the other ganglia farther along always demonstrated some RFamide-like immunoreactive regions (data not shown) suggestive of the neurohemal organs described by Raabe (1989). Each ganglion had an extensive immunoreactive neuropil region that is outlined in Figure 4 and seen clearly in Figure 5C (arrows).…”

Section: Fmrfamide-related Peptides In the Ventral Nerve Cordmentioning

confidence: 85%

In situ hybridization analysis of leucomyosuppressin mRNA expression in the cockroach,Diploptera punctata

Fusé

et al. 1998

J. Comp. Neurol.

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In the cockroach Diploptera punctata, sequencing of the cDNA for the insect myoinhibitory neuropeptide, leucomyosuppressin (LMS), has demonstrated that LMS is the only Phe-Met-Arg-Phe-amide (NH2) (FMRFamide)-related peptide to be encoded by this gene (Donly et al. [1996] Insect Biochem. Mol. Biol. 26:627-637). However, in the present study, high performance liquid chromatography analysis of brain extracts showed six discrete FMRFamide-like immunoreactive fractions, one of which co-eluted with LMS. This study compared the distribution of FMRFamide-related peptides visualized by immunohistochemistry with LMS mRNA expression demonstrated by in situ hybridization in D. punctata. Immunohistochemistry with a polyclonal antiserum generated against FMRFamide, but which recognizes extended RFamide peptides, demonstrated numerous RFamide-like immunoreactive cells and processes in both nervous and nonnervous tissues. RFamide-like immunoreactivity was found in cells and processes of the brain and optic lobes, the stomatogastric nervous system, including the frontal and ingluvial ganglia, and the suboesophageal ganglion. Immunoreactivity was also present in all ganglia of the ventral nerve cord and in the alimentary canal. Within the alimentary canal, positively stained processes were found in the crop, midgut, and hindgut, and immunoreactive endocrinelike cells were located in the midgut. In situ hybridization with a digoxigenin-labeled RNA probe spanning the entire LMS coding region showed cell bodies containing LMS mRNA in all ganglia studied, other than the ingluvial ganglion. Expression was most abundant in the brain and optic lobes and in the frontal and suboesophageal ganglia. LMS mRNA was also apparent, although less intensely, in all other ganglia of the ventral nerve cord. Within the alimentary canal, LMS mRNA-positive cells were only visible in the anterior portion of the midgut, in the endocrinelike cells. The appearance of LMS mRNA in the central nervous system, stomatogastric nervous system, and midgut suggests that LMS may play a central role in Diploptera and may be associated with feeding and digestion.

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Section: Fmrfamide-related Peptides In the Ventral Nerve Cordmentioning

confidence: 85%

In situ hybridization analysis of leucomyosuppressin mRNA expression in the cockroach,Diploptera punctata

Fusé

et al. 1998

J. Comp. Neurol.

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“…The majority of NSCs are found in the dorso-medial protocerebrum, the so-called pars intercerebralis (PI) and pars lateralis (PL; Pipa 1978, Raabe 1989, Schooneveld 1998, Veelaert et al 1998, Siegmund & Korge 2001. These NSCs project their axons toward a set of endocrine glands, the corpora cardiaca (CC) and corpora allata (CA; Fig.…”

Section: Neuroendocrine System Of Arthropodsmentioning

confidence: 99%

The neuroendocrine system of invertebrates: a developmental and evolutionary perspective

Hartenstein¹

2006

Journal of Endocrinology

261

216

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Neuroendocrine control mechanisms are observed in all animals that possess a nervous system. Recent analyses of neuroendocrine functions in invertebrate model systems reveal a great degree of similarity between phyla as far apart as nematodes, arthropods, and chordates. Developmental studies that emphasize the comparison between different animal groups will help to shed light on questions regarding the evolutionary origin and possible homologies between neuroendocrine systems. This review intends to provide a brief overview of invertebrate neuroendocrine systems and to discuss aspects of their development that appear to be conserved between insects and vertebrates.

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“…The numbers and relative positions of the cysteines of the insect peptide are equivalent to those of mammalian insulins and most of the hydrophobic core residues are conserved, confirming that this peptide is actually a member of the insulin superfamily (Lagueux et al, 1990). Native Locustu insulin-related peptide (LIRP) was subsequently isolated from neurohaemal lobes of the corpora cardiaca (Hetru et al, 1991), which serve as storage organs for brain neurosecretory peptides (reviewed in Raabe, 1989). Its peptide sequence, as established by Edman degradation, confirmed the sequence predicted from the cloned cDNA.…”

mentioning

confidence: 98%

Expression of the gene encoding an insulin‐related peptide inLocusta (Insecta, Orthoptera)

Kromer‐Metzger

Lagueux

1994

European Journal of Biochemistry

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A peptide with significant sequence similarity to mammalian insulins, Locustu insulin-related peptide (LIRP) has recently been isolated from neurohaemal lobes of Lacustu migrutoriu and the corresponding cDNA has been cloned. We report here the cloning of the LIRP gene and we show that this gene is present as a single copykaploid genome. The organization of this gene is similar to that of mammalian insulin genes. There are at least two LIRP transcripts, LIRP T1 and LIRP T2, differing in their 5' untranslated regions and in the 5' end of the coding region resulting in an additional ATG present in LIRP T2. The two transcripts are differentially expressed in Locustu; whereas LIRP T1 is only expressed in neurosecretory cells of the brain, LIRP T2 is present at low levels in all tissues. Our data indicate that the LIRP gene has at least two promoters, the alternative usage of which could account for a differential regulation of expression of LIRP in the neurosecretory cells and in various peripheral tissues.

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Recent Developments in Insect Neurohormones

Cited by 101 publications

References 0 publications

In situ hybridization analysis of leucomyosuppressin mRNA expression in the cockroach,Diploptera punctata

In situ hybridization analysis of leucomyosuppressin mRNA expression in the cockroach,Diploptera punctata

The neuroendocrine system of invertebrates: a developmental and evolutionary perspective

Expression of the gene encoding an insulin‐related peptide inLocusta (Insecta, Orthoptera)

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