Recent Developments in Palladium-Catalyzed Heterocycle Synthesis and Functionalization

Biaryl Phosphane Ligands in Palladium‐Catalyzed Amination

“…[144][145][146][147][148] The indole nucleus appears in many important compounds and a number of palladium-based methods have been disclosed for its synthesis and functionalization. [149] The introduction of highly reactive dialkylbiaryl phosphine palladium complexes, however, has allowed some significant new protocols to be developed.…”

Biarylphosphanliganden in der palladiumkatalysierten Aminierung

“…[144][145][146][147][148] Zur Synthese und Funktionalisierung des Indolsystems, das in vielen wichtigen Verbindungen enthalten ist, stand schon eine Reihe von palladiumkatalysierten Methoden zur Verfü-gung, [149] die Einführung hoch reaktiver Palladium-Dialkylbiarylphosphan-Komplexe führte darüber hinaus zu einigen bedeutenden neuen Verfahren.…”

Iridium-catalyzed borylation of thiophenes: versatile, synthetic elaboration founded on selective C–H functionalization

“…More recently, attention has turned to other methods for derivatizing C-H [16][17][18] and C-X [18][19][20][21][22] bonds in heterocycles with an emphasis on transition metal catalyzed processes that obviate the requirement for stoichiometric metal. While the emerging methodologies can sometimes bypass intermediates for certain syntheses, they can also offer selectivities that complement metalation reactions.…”