Recent developments in the diagnosis and treatment of subcutaneous mycoses

Randhawa, H. S.; Budimulja, Unandar; Bazaz-Malik, G; Bramono, Kusmarinah; Hiruma, Masataro; Kullavanijaya, Preya; Rojanavanich, Viboon

doi:10.1080/02681219480000921

Cited by 15 publications

(11 citation statements)

References 31 publications

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“…ITZ has been used in the treatment of several fungal infections including systemic ones 16 . At the moment, various authors indicate oral ITZ as choice therapy because of several reports showing cure or clinical improvement published in the last few years 4, 5, 17 . Reports of fungal resistance to ITZ are uncommon and restricted to a few cases of clinical/microbiologic resistance of certain Candida and Aspergillus species, and F. pedrosoi 8,9,18,19 …”

Section: Discussionmentioning

confidence: 99%

Susceptibility of sequential Fonsecaea pedrosoi isolates from chromoblastomycosis patients to antifungal agents

Andrade

Castro

Nunes

et al. 2004

Mycoses

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Fourteen Fonsecaea pedrosoi isolates from six chromoblastomycosis patients were submitted to susceptibility testing. Some patients were undergoing treatment with itraconazole (ITZ) and/or cryosurgery with liquid nitrogen. The antifungal agents amphotericin B (AMB), ITZ, fluconazole (FCZ), ketoconazole (KCZ), 5-fluorocytosine (5-FC), and terbinafine (TBF) were tested. AMB and FCZ showed less activity for all isolates. The most active agents were KCZ and TBF. Sequentially isolates from four patients presented ITZ minimal inhibitory concentration (MIC) higher than the previous ones; for two of these patients, response to therapy with this agent was not observed. These results suggest development of microbiologic resistance to ITZ in four instances, two of them coinciding with lack of clinical response to this drug.

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Section: Discussionmentioning

confidence: 99%

Susceptibility of sequential Fonsecaea pedrosoi isolates from chromoblastomycosis patients to antifungal agents

Andrade

Castro

Nunes

et al. 2004

Mycoses

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“…recovered from both humans and animals, including C. lampragues (Kimura et al 2011;Choon et al 2012;Tondolo et al 2013). In contrast, in vitro studies of B. ranarum showed inhibitory and fungicidal susceptibility to miconazole and ketoconazole (400 mg daily) (Villasco et al 1966;Saka et al 2010) and some clinical response to AmB, itraconazole (200 mg per day), and fluconazole (Randhawa et al 1994). However, treatment with AmB alone has given unsatisfactory results (Khan et al 2001).…”

Section: Managementmentioning

confidence: 96%

Human Fungal Pathogens of Mucorales and Entomophthorales

Mendoza

Vilela

Voelz

et al. 2014

Cold Spring Harbor Perspectives in Medicine

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In recent years, we have seen an increase in the number of immunocompromised cohorts as a result of infections and/or medical conditions, which has resulted in an increased incidence of fungal infections. Although rare, the incidence of infections caused by fungi belonging to basal fungal lineages is also continuously increasing. Basal fungal lineages diverged at an early point during the evolution of the fungal lineage, in which, in a simplified four-phylum fungal kingdom, Zygomycota and Chytridiomycota belong to the basal fungi, distinguishing them from Ascomycota and Basidiomycota. Currently there are no known human infections caused by fungi in Chytridiomycota; only Zygomycotan fungi are known to infect humans. Hence, infections caused by zygomycetes have been called zygomycosis, and the term "zygomycosis" is often used as a synonym for "mucormycosis." In the four-phylum fungal kingdom system, Zygomycota is classified mainly based on morphology, including the ability to form coenocytic (aseptated) hyphae and zygospores (sexual spores). In the Zygomycota, there are 10 known orders, two of which, the Mucorales and Entomophthorales, contain species that can infect humans, and the infection has historically been known as zygomyEditors:

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“…The presence of the typical developmental stages in histological sections is considered diagnostic for Rhinosporidium seeberi infection (Arseculeratne, 2002). Radical surgical excision of the lesions by laser or electric diathermy is generally considered to be the only successful treatment in human medicine (Randhawa et al., 1994), although lesions can recur. Therefore, the horse was scheduled for a similar procedure.…”

Section: Historymentioning

confidence: 99%