Recent Developments in Therapeutic and Nutraceutical Applications of p-Methoxycinnamic Acid from Plant Origin

Abstract

The p-methoxycinnamic acid (p-MCA) is one of the most studied phenylpropanoids with high importance not only in the wide spectrum of therapeutic activities but also its potential application for the food industry. This natural compound derived from plants exhibits a wide range of biologically useful properties; therefore, during the last two decades it has been extensively tested for therapeutic and nutraceutical applications. This article presents the natural sources of p-MCA, its metabolism, pharmacokinetic properties, and safety of its application. The possibilities of using this dietary bioactive compound as a nutraceutical agent that may be used as functional food ingredient playing a vital role in the prevention and treatment of many chronic diseases is also discussed. We present the antidiabetic, anticancer, antimicrobial, hepato-, and neuroprotective activities of p-MCA and methods of its lipophilization that have been developed so far to increase its industrial application and bioavailability in the biological systems.

Naturally Occurring Functional Ingredient from Filamentous Thermophilic Cyanobacterium Leptolyngbya sp. KC45: Phytochemical Characterizations and Their Multiple Bioactivities

“…Table 3 shows the comparison of identified compounds with previous studies [ 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 , 84 , 85 , 86 , 87 , 88 , 89 , 90 , 91 ,…”

8-Hydroxyquinolines: A Promising Pharmacophore Potentially Developed as Disease-Modifying Agents for Neurodegenerative Diseases: A Review

“…Cinnamic acid is a natural compound found in various plants and spices. 152 Piperazine is a moiety found in many approved drugs and is widely used as a linker for designing of novel compounds. 153 A series of 8HQ-cinnamic acid with piperazine linker were developed as multifunctional compounds.…”

Synthesis of PMCA (P-Methoxy Cinnamic Acid) using Perkin Reaction and Its Activity as Photo Protective and Antifungal Agent

“…This indicated that the compound p-methoxy cinnamic acid could act as an excellent sunscreen agent. P-methoxy cinnamic acid has a chromophore group, which is a conjugated double bond in its aromatic ring, aliphatic C=C, a C=O group, and an auxochrome group from OCH3 [1] so that it can absorb UV B rays and can be used as an active sunscreen agent with excellent potential [22][23].…”

“…P-methoxy cinnamic acid is one of the cinnamic acid derivative compounds substituted for a methoxy group at the para position [1]. The compound p-methoxy cinnamic acid has activity as an antibacterial [2][3], an anti-inflammatory and anticancer [4], antioxidant, antidiabetic [5], hepatoprotective, neuroprotective, and chemopreventive activity [1].…”

“…P-methoxy cinnamic acid is one of the cinnamic acid derivative compounds substituted for a methoxy group at the para position [1]. The compound p-methoxy cinnamic acid has activity as an antibacterial [2][3], an anti-inflammatory and anticancer [4], antioxidant, antidiabetic [5], hepatoprotective, neuroprotective, and chemopreventive activity [1]. P-methoxy cinnamic acid can be obtained through a hydrolysis reaction by transforming ethyl p-methoxycinnamate from the isolation of natural ingredients, namely aromatic ginger (Kaempheria galanga L.) [2] and the Perkin reaction.…”