Recent Developments of Flavonoids with Various Activities

Abstract

Flavonoids, a series of compounds with C6-C3-C6 structure, mostly originate from plant metabolism. Flavonoids have shown beneficial effects on many aspects of human physiology and health. Recently, many flavonoids with various activities have been discovered, which has led to more and more studies focusing on their physiological and pharmacodynamic activities. The anti-cancer and anti-viral activities especially have attracted the attention of many researchers. Therefore, the discovery and development of flavonoids as anti-disease drugs has great potential and may make significant contribution to fighting diseases. This review focus on the discovery and development of flavonoids in medicinal chemistry in recent years.

Structural insights and shedding light on preferential interactions of dietary flavonoids with G-quadruplex DNA structures: A new horizon

“…Increasing data suggests that flavonoids may target G-quadruplex structures [ 51 , 52 ]. Luteolin, rutin, quercetin, genistein, kaempferol, hesperidin, myricetin, and daidzein are prevalent dietary flavonoids that have garnered substantial interest for its anti-metastatic, anti-angiogenesis and anti-proliferative activities [ 53 , 54 ]. Previously, one study found that quercetin interacts with monomeric and dimeric G-quadruplex structures generated by a short repetition of the human telomeric region.…”

Antimicrobial Activity of Dimeric Flavonoids

“…These compounds are responsible for the coloration of leaves, flowers and fruits, and have a fundamental role in the protection of plants as oxidizing and microbial agents [18]. As a class of polyphenols, flavonoids can be divided in flavones (apigenin), flavanones (naringenin), flavans (catechin), flavonoid glycosides, flavonols (quercetin), flavonolignan (silibinin), chalcones (butein), isoflavones (genistein), aurones (aureusidin), leucoanthocynidins (leucopelargonidin) and neoflavonoids (neoflavones) [19][20][21].…”

Quercetin ameliorated cardiac injury via reducing inflammatory actions and the glycerophospholipid metabolism dysregulation in a diabetic cardiomyopathy mouse model

“…Flavonoids are widely distributed in foods and beverages of plant origin, such as fruits, vegetables, tea, and cocoa, in which quercetin is one of the most frequently occurring flavonoids. 12,13 Population-based studies have found that diets rich in quercetin confer lower cardiovascular morbidity. 14,15 In rodent experiments, quercetin has multifactorial pharmacological effects such as anti-inflammatory, immune-regulatory, free radical scavenging, and hypolipidemic effects.…”