Recent developments of ion sources for life-science studies at the Heavy Ion Medical Accelerator in Chiba (invited)

Kitagawa, A.; Drentje, A.G.; Fujita, Takeshi; Muramatsu, M.; Fukushima, K.; Shiraishi, Nobuo; Suzuki, Taku; Takahashi, Katsuyuki; Takasugi, W.; Biri, S.; Rácz, R.; Kato, Yushi; Uchida, Takashi; Yoshida, Yoshikazu

doi:10.1063/1.4934843

Cited by 9 publications

(4 citation statements)

References 20 publications

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“…The KLY was used daring output power of 0 to 1200 W (blue dot). Two-frequency heating method [8,9,10] was used from 1300 to 2000 W (red dot). Dotted line shows requirement values.…”

Section: Beam Test At the Nirs-hec Ion Sourcementioning

confidence: 99%

Concept design of new compact electron cyclotron resonance ion source with permanent magnets for multi-ion radiotherapy

Muramatsu

Ouchi

Suzuki

et al. 2022

J. Phys.: Conf. Ser.

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The multi-ion radiotherapy with dose distribution and Liner Energy Transfer optimization is being studied at QST. Helium, carbon, oxygen and neon ions are considered as ion species for multi-ion therapy. A basic experiment using these ion beams has been carried out at the HIMAC. For heavy-ion radiotherapy facility, it is desirable to operate with only one ECR ion source with permanent magnets from the viewpoint of cost and maintenance. We considered the operating method with only one ion source for multi-ion radiotherapy. Ionization gases were helium, methane, oxygen, and neon to produce He2+, C4+, O6+ and Ne7+ ions. Requirement values of beam current were 940 μA correspond to He2+, 290 μA to C4+, 330 μA to O6+, and 245 μA to Ne7+, respectively. This value was obtained from the number of particles required for the cancer treatment and the transmission efficiency of the accelerator in the HIMAC. We performed some beam tests for design of a new compact ion source with the existing 18 GHz ECR ion source (NIRS-HEC). From the results of the beam tests, we estimate the mirror magnetic field of NIRS-HEC by using POISSON/SUPERFISH code. Then, the structure of the permanent magnets for new ECR ion source is determined so that they reproduce the values of the upstream mirror peak (Binj), B minimum (Bmin) and the downstream mirror peak (Bext) at the NIRS-HEC. The magnetic field of Binj, Bmin and Bext at NIRS-HEC were 1.14 T, 0.475 T and 0.9 T, respectively.

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“…The KLY was used daring output power of 0 to 1200 W (blue dot). Two-frequency heating method [8,9,10] was used from 1300 to 2000 W (red dot). Dotted line shows requirement values.…”

Section: Beam Test At the Nirs-hec Ion Sourcementioning

confidence: 99%

Concept design of new compact electron cyclotron resonance ion source with permanent magnets for multi-ion radiotherapy

Muramatsu

Ouchi

Suzuki

et al. 2022

J. Phys.: Conf. Ser.

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“…Heavy-ion beams are generated from space or ion-beam acceleration facilities in the ground such as cyclotron or synchrotron (Shi et al 2014). Presently, there are a series of ion-beam acceleration facilities in the world dedicating to nuclear and high-energy physics, material science, life science studies and so on, such as Gesellschaft f€ ur Schwerionenforschung (GSI, Darmstadt, Germany), Grand Acc el erateur National d'Ions Lourds (GANIL, Caen, France), Heavy Ion Medical Accelerator in Chiba (HIMAC, Chiba, Japan), Institute of Modern Physics Chinese Academy of Sciences (IMP CAS, Lanzhou, China) and Radioactive Isotope Beam Factory (RIBF, Saitama, Japan) (Sutherland et al 2000;Abe et al 2015;Kitagawa et al 2016).…”

Section: Description Of Heavy-ion Beam Bioengineering Facility At Impmentioning

confidence: 99%

Recent advances of microbial breeding via heavy-ion mutagenesis at IMP

Chen

2017

Lett Appl Microbiol

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Significance and Impact of the Study: There is currently a great interest in developing rapid and diverse microbial mutation tool for strain modification. Heavy-ion mutagenesis has been proved as a powerful technology for microbial breeding due to its broad spectrum of mutation phenotypes with high efficiency. In order to deeply understand heavy-ion mutagenesis technology, this paper briefly reviews recent progress in microbial breeding using heavy-ion mutagenesis at IMP, and also presents the outline of the beam line for microbial breeding in Heavy Ion Research Facility of Lanzhou (HIRFL) as well as new insights into microbial biotechnology via heavy-ion mutagenesis. Thus, this work can provide the guidelines to promote the development of novel microbial biotechnology cross-linking heavy-ion mutagenesis breeding that could make breeding process more efficiently in the future. Abstract Nowadays, the value of heavy-ion mutagenesis has been accepted as a novel powerful mutagen technique to generate new microbial mutants due to its high linear energy transfer and high relative biological effectiveness. This paper briefly reviews recent progress in developing a more efficient mutagenesis technique for microbial breeding using heavy-ion mutagenesis, and also presents the outline of the beam line for microbial breeding in Heavy Ion Research Facility of Lanzhou. Then, new insights into microbial biotechnology via heavy-ion mutagenesis are also further explored. We hope that our concerns will give deep insight into microbial breeding biotechnology via heavy-ion mutagenesis. We also believe that heavy-ion mutagenesis breeding will greatly contribute to the progress of a comprehensive study industrial strain engineering for bioindustry in the future.

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“…It plays an important role in medical field of carbon cancer therapy and aerospace engineering field of artificial satellite engine. [2,3] The satellite engine uses an ion engine, and Xe is widely used as fuel. There are problems of accumulation damages at irradiating and sputtering by low energy Xe ion from the engine.…”

Section: Introductionmentioning

confidence: 99%

Optimized deceleration characteristics of multicharged ion beams from electron cyclotron resonance ion source

Sato

Harisaki

Kubo

et al. 2022

J. Phys.: Conf. Ser.

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At present it is necessary the satellite lifetime 10-15 years for operating in space. Xenon is used as fuel for ion engines of satellites. There are problems of accumulated damages at irradiation and sputtering by low energy Xe ion from the engine. It is required to construct database of sputtering yield of ion beams in the low energy region from a hundred eV to 1keV. We are trying to investigate experimentally sputtering yield on satellite component by irradiating the low energy Xe q+ ion beams. We use the electron cyclotron resonance ion source (ECRIS) in the irradiation experiments. We decelerate the beam energy to several hundred eV after extraction at high voltage 10kV. It is found we cannot neglect the contribution of the space potential of the plasma in the ECRIS of several tens eV. We measured the plasma parameters and ion beam deceleration characteristics in operating conditions on ECRIS. As the results, it was found in operating ECRIS condition of low charge state ion being dominant that the space potential of the ECRIS has an effect of 10∼20% at the beam energy at about 100eV in conducting irradiation experiments on satellite component materials.

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Recent developments of ion sources for life-science studies at the Heavy Ion Medical Accelerator in Chiba (invited)

Cited by 9 publications

References 20 publications

Concept design of new compact electron cyclotron resonance ion source with permanent magnets for multi-ion radiotherapy

Concept design of new compact electron cyclotron resonance ion source with permanent magnets for multi-ion radiotherapy

Recent advances of microbial breeding via heavy-ion mutagenesis at IMP

Optimized deceleration characteristics of multicharged ion beams from electron cyclotron resonance ion source

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