Recent Developments of Nanostructures for the Ocular Delivery of Natural Compounds

Razavi, Malihe Sadat; Ebrahimnejad, Pedram; Fatahi, Yousef; D’Emanuele, Antony; Dinarvand, Rassoul

doi:10.3389/fchem.2022.850757

Cited by 35 publications

(14 citation statements)

References 213 publications

(241 reference statements)

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“…Delivering drugs to the eye is a difficult task due to the presence of several barriers that limit the effectiveness of drug delivery [ 146 ]. These barriers include the tear film, cornea, blood-aqueous, and blood-retinal barriers.…”

Section: New Formulationsmentioning

confidence: 99%

Potential therapeutic effects of green tea (Camellia sinensis) in eye diseases, a review

Boroughani,

Tahmasbi,

Heidari

et al. 2024

Heliyon

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Section: New Formulationsmentioning

confidence: 99%

Potential therapeutic effects of green tea (Camellia sinensis) in eye diseases, a review

Boroughani,

Tahmasbi,

Heidari

et al. 2024

Heliyon

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“…Curcumin (CUR), resveratrol (RSV), ferulic acid, and the previously mentioned quercetin are natural bioactive substances with powerful antioxidant and anti-inflammatory properties that have intrigued researchers, and there is growing evidence that they have great potential to treat ocular diseases [ 145 , 146 , 147 , 148 ]. However, poor physicochemical and pharmacokinetic properties make effective delivery to the eye a challenge.…”

Section: Advances In Nanogels For Ocular Diseasesmentioning

confidence: 99%

Advances in Nanogels for Topical Drug Delivery in Ocular Diseases

Tao

Xie

et al. 2023

Gels

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Nanotechnology has accelerated the development of the pharmaceutical and medical technology fields, and nanogels for ocular applications have proven to be a promising therapeutic strategy. Traditional ocular preparations are restricted by the anatomical and physiological barriers of the eye, resulting in a short retention time and low drug bioavailability, which is a significant challenge for physicians, patients, and pharmacists. Nanogels, however, have the ability to encapsulate drugs within three-dimensional crosslinked polymeric networks and, through specific structural designs and distinct methods of preparation, achieve the controlled and sustained delivery of loaded drugs, increasing patient compliance and therapeutic efficiency. In addition, nanogels have higher drug-loading capacity and biocompatibility than other nanocarriers. In this review, the main focus is on the applications of nanogels for ocular diseases, whose preparations and stimuli-responsive behaviors are briefly described. The current comprehension of topical drug delivery will be improved by focusing on the advances of nanogels in typical ocular diseases, including glaucoma, cataracts, dry eye syndrome, and bacterial keratitis, as well as related drug-loaded contact lenses and natural active substances.

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“…The small size of resveratrol allows the drug to pass through the cornea and to the retina; however, the low bioavailability makes its applicability limited. [ 45 ]…”

Section: Resveratrol Deliverabilitymentioning

confidence: 99%

Resveratrol for dry eye disease – Hope or Hype?

Shetty

Joshi

Mahendran

et al. 2023

Indian Journal of Ophthalmology

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Dry eye disease (DED) is a multifactorial and common ophthalmic disease that has a tremendous effect on the quality of life. It is now becoming a public health concern because of our changing lifestyle and environment. The current treatment modalities, artificial tear substitutes, and anti-inflammatory therapy are directed at dry eye symptoms. One of the major drivers for DED is oxidative stress, and the polyphenol group of natural compounds has the potential to reduce the same. Resveratrol, widely found in the skin of grapes and nuts, has antioxidative and anti-inflammatory properties. It has been shown to have beneficial effects in glaucoma, age-related macular degeneration, retinopathy of prematurity, uveitis, and diabetic retinopathy. Studies have also explored the beneficial effects of resveratrol in DED, making it as a promising therapeutic molecule. Resveratrol has not yet reached clinical application because of difficulty in deliverability and low bioavailability. In this review, we explore the potential of resveratrol in DED treatment based on various in vitro and in vivo studies.

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Recent Developments of Nanostructures for the Ocular Delivery of Natural Compounds

Abstract: Graphical AbstractApplication of nanostructures in ocular delivery of natural products.

Cited by 35 publications

References 213 publications

Potential therapeutic effects of green tea (Camellia sinensis) in eye diseases, a review

Potential therapeutic effects of green tea (Camellia sinensis) in eye diseases, a review

Advances in Nanogels for Topical Drug Delivery in Ocular Diseases

Resveratrol for dry eye disease – Hope or Hype?

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