Recent Findings on the Effects of Pharmacological Agents on the Nerve Regeneration after Peripheral Nerve Injury

Bolandghamat, Samira; Rassouli, Morteza Behnam

doi:10.2174/1570159x18666200507084024

Cited by 11 publications

(4 citation statements)

References 112 publications

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“…A number of possible adjuvant therapies putatively targeting these factors have been observed to be efficacious in the laboratory setting but evidence for improvement in humans is lacking. Examples include atorvastatin and L-carnitine ( 67 ). Both have been shown to have neuroprotective effects in CNS injury and degenerative models in rat models.…”

Section: Adjuvant Therapies In Nerve Transfer Surgerymentioning

confidence: 99%

Assessment, patient selection, and rehabilitation of nerve transfers

Bateman,

Larocerie-Salgado,

Ross

et al. 2023

Front. Rehabil. Sci.

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Peripheral nerve injuries are common and can have a devastating effect on physical, psychological, and socioeconomic wellbeing. Peripheral nerve transfers have become the standard of care for many types of peripheral nerve injury due to their superior outcomes relative to conventional techniques. As the indications for, and use of, nerve transfers expand, the importance of pre-operative assessment and post-operative optimization increases. There are two principal advantages of nerve transfers: (1) their ability to shorten the time to reinnervation of muscles undergoing denervation because of peripheral nerve injury; and (2) their specificity in ensuring proximal motor and sensory axons are directed towards appropriate motor and sensory targets. Compared to conventional nerve grafting, nerve transfers offer opportunities to reinnervate muscles affected by cervical spinal cord injury and to augment natural reinnervation potential for very proximal injuries. This article provides a narrative review of the current scientific knowledge and clinical understanding of nerve transfers including peripheral nerve injury assessment and pre- and post-operative electrodiagnostic testing, adjuvant therapies, and post-operative rehabilitation for optimizing nerve transfer outcomes.

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Section: Adjuvant Therapies In Nerve Transfer Surgerymentioning

confidence: 99%

Assessment, patient selection, and rehabilitation of nerve transfers

Bateman,

Larocerie-Salgado,

Ross

et al. 2023

Front. Rehabil. Sci.

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“…Велика кількість досліджень на сьогодні проводиться щодо застосування можливих фармакологічних [15,16,17] та фізіотерапевтичних агентів [18], які можуть сприяти покращенню регенерації нерва. Окрім того, значна кількість авторів вбачає подальший розвиток хірургії периферійних нервів саме в досягненнях регенеративної медицини [19,20] та їхній комбінації з класичними хірургічними методиками [3].…”

Section: вступunclassified

Experimental Study of the Bone Marrow Aspirate Injection Effect into Denervated Muscle (Clinical Manifestations of Limb Denervation)

Страфун

Lysak

Huzovatyi³

2022

HOTP

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Relevance. Peripheral nerve injuries are potentially disabling lesions, which account for about 2-3% of all injuries. In order to study the clinical manifestations of limb denervation in the early and late stages, we conducted an experimental study. Objective: in the experiment, to study the effect of bone marrow aspirate injection into the target muscles on denervation-reinnervation processes by studying the clinical manifestations of denervation (presence of trophic ulcers, edema, or muscle wasting). Materials and Methods. The experiment was performed on 36 rabbits, which were divided into four groups: a group of pseudo-operated animals, group 1 (neurotomy and sciatic nerve suture), group 2 (on-time injection of bone marrow aspirate), and group 3 (delayed injection of bone marrow aspirate). Detection of hypotrophy or edema of the tibia was performed by determining the percentage of leg circumference of the operated on and intact limbs. Clinical manifestations of limb denervation were recorded during the examination of experimental animals before their euthanasia. Results. When comparing the number of complications in group 1 and group 2, more complications of the denervation process was observed in group 1. At the same time, no difference was found between group 1 and group 3, as well as between group 2 and group 3. When comparing the indicators of hypotrophy, the difference between group 1 and group 2, as well as a significant difference (p<0.05) between group 1 and group 3, with a predominance of hypotrophy in group 2 and group 3 were revealed. Conclusions. The injection of bone marrow aspirate into the target muscles during surgery and in the early stages of reinnervation helped to reduce the clinical manifestations of the denervation process. Delayed administration of bone marrow aspirate to target muscles significantly (p<0.05) helped to reduce edema of denervated target muscles.

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“…Despite the increasing development of current microsurgical repair techniques, incomplete neurological recovery with sequelae often occurs [43]. The combined use of nerve regeneration drugs and microsurgery to treat peripheral nerve injury is one of the ideal treatment methods, but the neurotrophic drugs currently used are often unsatisfactory [44]. Finding an ideal drug to treat nerve injury is the current research direction.…”

Section: Neuroprotection and Promotion Of Nerve Regenerationmentioning

confidence: 99%

Polymers containing natural plant phenolic compounds for peripheral nerve injury

Zheng

Qiu

et al. 2022

BAB

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Peripheral nerve injury is a serious and disabling disease prevalent in the world. It caused by trauma is often accompanied with soft tissue injuries, fractures, infections, etc., and can cause permanent damage. The treatment methods of peripheral nerve injury mainly include traditional microsurgical repair, neurotrophic drug treatment, as well as cuttingedge nerve conduit treatment, nerve stimulation, cell therapy, etc. However, more than 30% of patients with peripheral nerve injury still have poor recovery, including partial loss or complete loss of motor and/or sensory function, muscle atrophy，chronic pain and severe disability, among can lead to permanent disease. Phenolic compounds are secondary metabolites which is the most abundant in plants, consisting of an aromatic ring and one or more hydroxyl substituents, the main groups including flavonoids, phenolic acids, tannins, stilbene and lignans. A lot of studies have shown that natural phenolic compounds have various properties, such as antioxidant, anti-infective, anticancer, anti-inflammatory, etc., and have broad applications in the prevention of heart disease, cancer, diabetes, oxidative stress-related diseases, and neuroprotection prospect. This review discusses the potential applications and molecular mechanisms of natural phenolic compounds its polymer derivatives in the treatment of peripheral nerve injury.

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Recent Findings on the Effects of Pharmacological Agents on the Nerve Regeneration after Peripheral Nerve Injury

Cited by 11 publications

References 112 publications

Assessment, patient selection, and rehabilitation of nerve transfers

Assessment, patient selection, and rehabilitation of nerve transfers

Experimental Study of the Bone Marrow Aspirate Injection Effect into Denervated Muscle (Clinical Manifestations of Limb Denervation)

Polymers containing natural plant phenolic compounds for peripheral nerve injury

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