Recent Immunohistochemical Approaches for Predicting Tumor Recurrence in Oral Squamous Cell Carcinoma (OSCC) : Actors Beyond the Scene

Zainul, Zarin

doi:10.5466/ijoms.10.406

Cited by 1 publication

(1 citation statement)

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“…[ 11 ] BUBR1 is also postulated to be a possible predictive marker for tumor recurrence as it was also found to be associated with tumor progression and the tumor recurrence in case of oral squamous cell carcinoma (OSCC). [ 12 ] They found that the overexpression of BUBR1 might be a new tumor marker for predicting a more aggressive biological behavior of solid human neoplasms. [ 11 ]…”

Section: Introductionmentioning

confidence: 99%

Immunohistochemical expression of budding uninhibited by benzimidazole related 1 in leukoplakia and oral squamous cell carcinoma

Sravya

Yeluri

Guttikonda

2016

J Oral Maxillofac Pathol

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Background:Budding uninhibited by benzimidazole related 1 (BUBR1) is an important protein in the mitotic spindle assembly checkpoint. Alterations in expression of BUBR1 have been reported in many premalignant and malignant lesions.Aim:To compare the expression of BUBR1 with respect to the normal mucosa and degree of dysplasia in oral leukoplakia (OL) and also with respect to different histopathological grades of oral squamous cell carcinoma (OSCC).Materials and Methods:Neutral buffered formalin-fixed and paraffin-embedded biopsy specimens 30 each of normal, OL and OSCC tissue were included in this study. The expression of BUBR1 was detected using immunohistochemistry (IHC). The scores obtained were subjected to ANOVA test.Results:Significant correlation was found in immunostaining between normal, dysplasia and OSCC groups with a P value of 0.00001. The expression of BUBR1 was significant when compared with different degrees of dysplasia and in different histopathological grades of OSCC with a P value of 0.00001.Conclusion:Higher IHC scores were obtained with increased histopathological grades of OL and OSCC suggesting its role as a prognostic indicator.

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Section: Introductionmentioning

confidence: 99%