Recent insights into the nutritional immunomodulation of cancer‐related microRNAs

Abstract

Cancer is the most common cause of death worldwide, following cardiovascular diseases. Cancer is a multifactorial disease and many reasons such as physical, chemical, biological, and lifestyle‐related factors. Nutrition, which is one of the various factors that play a role in the prevention, development, and treatment of many types of cancer, affects the immune system, which is characterized by disproportionate pro‐inflammatory signaling in cancer. Studies investigating the molecular mechanisms of this effect have shown that foods rich in bioactive compounds, such as green tea, olive oil, turmeric, and soybean play a significant role in positively changing the expression of miRNAs involved in the regulation of genes associated with oncogenic/tumor‐suppressing pathways. In addition to these foods, some diet models may change the expression of specific cancer‐related miRNAs in different ways. While Mediterranean diet has been associated with anticancer effects, a high‐fat diet, and a methyl‐restricted diet are considered to have negative effects. This review aims to discuss the effects of specific foods called “immune foods,” diet models, and bioactive components on cancer by changing the expression of miRNAs in the prevention and treatment of cancer.

Green and environmentally friendly synthesis of silver nanoparticles with antibacterial properties from some medicinal plants

“…Turmeric is globally popular due to its appealing culinary, cosmetic, and medical applications. Various medical activities such as protection against light, skin protection, anti-asthma, blood sugar reduction, pain relief [ 36 ], anti-microbial [ 37 ], antioxidant [ 38 ], and anticancer [ 39 ] have been reported for it [ 40 , 41 ]. Recently, turmeric powder has been used as a traditional medicine for the management of digestive system ailments, especially gallbladder and liver disease, diabetes, rheumatism, sinusitis, anorexia, rhinitis, and cough [ 42 ].…”

Novel role of lncRNAs regulatory network in papillary thyroid cancer

“…These proteins can serve as biomarkers to facilitate diagnosis and prognostic evaluation of tumors. 3.microRNAs (miRNAs): TO et al have proposed that miRNAs can be used as a novel biomarker for tumors, and employing miRNAs in conjunction with gene treatments can effectively prevent the growth of tumors [ 22 ]. Similarly, several miRNAs in PTC demonstrate changed expression levels, such as miR-146b, miR-221, and miR-222 [ 23 ].…”

Apium extract alleviates indomethacin-induced gastric ulcers in rats via modulating the VEGF and IK-κB/NF-κB p65 signaling pathway: insights from in silico and in vivo investigations

“…Various herbal medicines are prevalently employed to treat and/or prevent many diseases including gastric ulcers [ 17 – 21 ]. The anti-ulcerogenic and gastroprotective potentials of natural products are attributed mostly to their diverse metabolic profile and antioxidant properties [ 22 – 24 ].…”