Recent insights on the genetics and epigenetics of endometriosis

Borghese, Bruno; Zondervan, Krina T.; Abrão, Maurício Simões; Chapron, Charles; Vaiman, Daniel

doi:10.1111/cge.12897

Cited by 151 publications

(112 citation statements)

References 133 publications

(129 reference statements)

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“…In our study, no significant difference was observed between the pre‐ and post‐treatment implant volumes in the control group, similar to the studies reported in the literature . However, a significant difference was found between the pre‐ and post‐treatment implant volumes in the ALA group.…”

Section: Discussionsupporting

confidence: 91%

Effect of alpha‐lipoic acid on endometrial implants in an experimental rat model

Pınar

Karapınar

Özcan

et al. 2017

Fundamemntal Clinical Pharma

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To investigate the antioxidant and anti-inflammatory effects of alpha-lipoic acid (ALA) in the treatment of endometriosis in an experimental rat model by evaluating biochemical and histopathologic parameters. Experimental endometriosis was induced by the peritoneal implantation of autologous endometrial tissue. The rats were randomly divided into two groups with eight rats each. Group I was intraperitoneally administered ALA 100 mg/kg/day for 14 days. Group II was intraperitoneally administered saline solution at the same dosage and over the same period. Endometrial implant volume was measured in both groups both pre- and post-treatment. Tumor necrosis factor alpha (TNF-α) was measured in peritoneal fluid. Total antioxidant status (TAS), total oxidant status (TOS), and oxidative stress index (OSI) were assessed in serum. The implants were histopathologically evaluated. In the ALA group, the serum TOS and OSI levels, the endometrial implant volumes, the TNF-α levels in serum and peritoneal fluid, and the histopathologic scores were significantly lower compared to the control group (P < 0.05). Alpha-lipoic acid may have a therapeutic potential in the treatment of endometriosis due to its antioxidant and anti-inflammatory effects.

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Section: Discussionsupporting

confidence: 91%

Effect of alpha‐lipoic acid on endometrial implants in an experimental rat model

Pınar

Karapınar

Özcan

et al. 2017

Fundamemntal Clinical Pharma

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“…In addition it had the greatest sensitivity and specific of any single miRNA in surgically diagnosed patients. Indeed when combined with miR-451a and mIR-3613-5p a maximum AUC score 1.00 was achieved [15].…”

Section: Investigations In Gynecology Research and Womens Healthmentioning

confidence: 97%

The Role of Biomarkers in the Early Diagnosis of Endometriosis

Worku¹

2017

IGRWH

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Endometriosis is a chronic gynecological problem which is frequent within the general population. Due to its varied presentations there is often a vast delay in diagnosis incurring a large amount of psychological and physical harm with infertility being unfortunate sequelae. Whilst improvements have been made with regards to the treatment of endometriosis, diagnosis remains challenging for clinicians with traditional investigations yielding poor results. This review will consider potential biomarkers and investigations for the early diagnosis of endometriosis.

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“…As described earlier 13,14 12 age-matched adult female Lewis rats (RRID: RGD_737932) obtained from Harlan Laboratories GmbH (Venray, The Netherlands), were subjected to ovariectomy (OVX) to reduce the levels of endogenous estrogen. Fourteen days after surgery the OVX animals were randomized to two treatment cohorts (n = 6).…”

Section: Animals and Dietmentioning

confidence: 99%

Role of miR‐203 in estrogen receptor‐mediated signaling in the rat uterus and endometrial carcinoma

Zierau

Helle

Schadyew

et al. 2018

J of Cellular Biochemistry

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The role of microRNAs (miRNA) in estrogen receptor (ER) signaling in the uterus and in endometrial cancer is not well understood. We therefore analyzed miRNA expression in uterine samples from a standard 3-day uterotrophic assay using young female adult rats to identify E2-regulated miRNAs. Microarray analysis identified 47 E2 down-regulated miRNAs including miR-30a, and 25 E2up-regulated miRNAs including miR-672, miR-203, and miR-146b. The strongly E2-upregulated miR-203 was selected for further analysis. miR-203 was deleted in the rat endometrial adenocarcinoma cell line, RUCA-I, using CRISPR/CAS9. Five clones devoid of miR-203 expression were generated. Proliferation was reduced and G2-arrest was observed in all miR-203 deficient RUCA-I clones. Transfection with a miR-203-3p mimic partially rescues this effect. Comparison of mRNA expression in three miR-203 knockout clones to wild type RUCA-I cells reveals 566 miR-203-upregulated and 592 miR-203-downregulated genes. 43 of the genes that are upregulated by miR-203 knockout in vitro are downregulated in the uterus by E2. Of these Acer2, Zbtb20, Ptn, Rcbtb2, Mum1l1, Hmgn3, and Nfat5 possess one or more seed sequence matches in their 3'-UTR that are predicted to be targets of miR-203. These data demonstrate the importance of E2 regulated miRNAs in general, and miR-203 in particular, for E2 regulated gene expression and physiological processes including proliferation and cell migration, in the uterus as well as in the etiology of endometrial carcinomas.

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Recent insights on the genetics and epigenetics of endometriosis

Cited by 151 publications

References 133 publications

Effect of alpha‐lipoic acid on endometrial implants in an experimental rat model

Effect of alpha‐lipoic acid on endometrial implants in an experimental rat model

The Role of Biomarkers in the Early Diagnosis of Endometriosis

Role of miR‐203 in estrogen receptor‐mediated signaling in the rat uterus and endometrial carcinoma

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