Recent Introduction and Rapid Dissemination of Chikungunya Virus and Dengue Virus Serotype 2 Associated With Human and Mosquito Coinfections in Gabon, Central Africa

Caron, Mélanie; Paupy, Christophe; Grard, Gilda; Becquart, Pierre; Mombo, Illich Manfred; Nso, Branly Bikie Bi; Kassa, Fabrice Kassa; Nkoghe, Dieudonné; Leroy, Eric M.

doi:10.1093/cid/cis530

Cited by 160 publications

(157 citation statements)

References 34 publications

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“…In one study by Caron et al, it was found that coinfection with Dengue and Chikungunya reduces the overall viral load in the affected patients. 7 More evidence-based research is required, however, to explain absence of thrombocytopenia in our patient. Since the effects of each of the viruses at the cellular level can be either complementary, additive and/or opposite, their presentation can be varied and unpredictable.…”

Section: Gbs Is Named After French Neurologists Georges Guillain and mentioning

confidence: 88%

Guillain-Barre Syndrome Following Combined Chikungunya and Dengue Infection: Critical Care Management and Future Research

Hariharan¹,

Chaudhary²,

Bhasin³

2017

Exploratory Research and Hypothesis in Medicine

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Guillain-Barre Syndrome (GBS) is an autoimmune inflammatory polyneuropathy, which usually develops following infectious diseases. It is a known complication of dengue fever, in particular; however, GBS following combined Dengue and Chikungunya infection is extremely rare. We hereby report a patient with combined Dengue and Chikungunya fever, without associated thrombocytopenia. The main concern in this case was the sudden development of GBS, which was responsive to double immunoglobulin therapy and required a percutaneous dilatational tracheostomy (PCT) to facilitate weaning from ventilation.

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Section: Gbs Is Named After French Neurologists Georges Guillain and mentioning

confidence: 88%

Guillain-Barre Syndrome Following Combined Chikungunya and Dengue Infection: Critical Care Management and Future Research

Hariharan¹,

Chaudhary²,

Bhasin³

2017

Exploratory Research and Hypothesis in Medicine

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“…Interestingly, DENV is still circulating in the Caribbean, together with CHIKV. Cases of DENV-CHIKV coinfection in patients were first reported in 1967 (54), and since the emergence of CHIKV, reports of coinfections have been increasing (10,(55)(56)(57)(58)(59)(60)(61)(62)(63). Both viruses are transmitted by the same mosquito vectors, A. aegypti and A. albopictus.…”

Section: Discussionmentioning

confidence: 99%

High Level of Vector Competence of Aedes aegypti and Aedes albopictus from Ten American Countries as a Crucial Factor in the Spread of Chikungunya Virus

Vega-Rúa

Zouache

Girod

et al. 2014

J Virol

383

357

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Chikungunya virus (CHIKV) causes a major public health problem. In 2004, CHIKV began an unprecedented global expansion and has been responsible for epidemics in Africa, Asia, islands in the Indian Ocean region, and surprisingly, in temperate regions, such as Europe. Intriguingly, no local transmission of chikungunya virus (CHIKV) had been reported in the Americas until recently, despite the presence of vectors and annually reported imported cases. Here, we assessed the vector competence of 35 American Aedes aegypti and Aedes albopictus mosquito populations for three CHIKV genotypes. We also compared the number of viral particles of different CHIKV strains in mosquito saliva at two different times postinfection. Primarily, viral dissemination rates were high for all mosquito populations irrespective of the tested CHIKV isolate. In contrast, differences in transmission efficiency (TE) were underlined in populations of both species through the Americas, suggesting the role of salivary glands in selecting CHIKV for highly efficient transmission. Nonetheless, both mosquito species were capable of transmitting all three CHIKV genotypes, and TE reached alarming rates as high as 83.3% and 96.7% in A. aegypti and A. albopictus populations, respectively. A. albopictus better transmitted the epidemic mutant strain CHIKV_0621 of the East-Central-South African (ECSA) genotype than did A. aegypti, whereas the latter species was more capable of transmitting the original ECSA CHIKV_115 strain and also the Asian genotype CHIKV_NC. Therefore, a high risk of establishment and spread of CHIKV throughout the tropical, subtropical, and even temperate regions of the Americas is more real than ever.

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“…Some studies using serological assays or PCR tests have reported that co-infection of DENV and CHIKV is not uncommon [10][11][12][13]19]. In a study performed in India in 2010, Taraphdar et al [10] found that 68 (12.4%) of 550 blood samples of febrile cases had IgM antibodies against both DENV and CHIKV.…”

Section: Discussionmentioning

confidence: 99%

“…In areas where both viruses co-circulate, both can be transmitted to the same human host and pose a challenge for medical diagnosis. DENV and CHIKV co-infection has been reported in several studies in a non-negligible proportion of cases [10][11][12]. However, fatalities in patients with DENV and CHIKV co-infection have been rare to date.…”

Section: Introductionmentioning

confidence: 99%

Clinical and histopathological features of fatal cases with dengue and chikungunya virus co-infection in Colombia, 2014 to 2015

et al. 2016

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histopathological features of fatal cases with dengue and chikungunya virus co-infection in Colombia, 2014. Euro Surveill. 201621(22) We report clinical features and histopathological findings in fatal cases with dengue (DENV) and chikungunya (CHIKV) co-infection identified at the Colombian National Institute of Health between September 2014 and October 2015. Seven such cases were documented. Dengue serotype 2 virus was identified in six cases. All patients were adults and comorbidities were present in four. Fever, arthralgia or myalgia was present in all cases. The frequency of rash, haemorrhage, oedema, and gastrointestinal symptoms was variable. Laboratory findings such as thrombocytopenia, renal failure, and leukocyte count were also inconsistent between cases. Post-mortem tissue examination documented focal hepatocellular coagulative necrosis in three cases, incipient acute pericarditis in one and tubulointerstitial nephritis in one. This study provides evidence of mortality in patients with DENV and CHIKV co-infection. Fatal cases were characterised by variable clinical and laboratory features. Evaluation of histopathology of autopsy tissues provided evidence of the pathological consequences of the disease.

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Recent Introduction and Rapid Dissemination of Chikungunya Virus and Dengue Virus Serotype 2 Associated With Human and Mosquito Coinfections in Gabon, Central Africa

Abstract: These findings show the rapid dissemination of CHIKV and DENV-2 within a nonimmune population in a tropical African country, probably facilitated by the spread of Aedes albopictus. This has resulted in major simultaneous outbreaks with numerous coinfections in both human and mosquito.

Cited by 160 publications

References 34 publications

Guillain-Barre Syndrome Following Combined Chikungunya and Dengue Infection: Critical Care Management and Future Research

Guillain-Barre Syndrome Following Combined Chikungunya and Dengue Infection: Critical Care Management and Future Research

High Level of Vector Competence of Aedes aegypti and Aedes albopictus from Ten American Countries as a Crucial Factor in the Spread of Chikungunya Virus

Clinical and histopathological features of fatal cases with dengue and chikungunya virus co-infection in Colombia, 2014 to 2015

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