Recent medical techniques for peripheral nerve repair: Clinico-physiological advantages of artificial nerve guidance conduits

Whole Body Vibration Training as the Novel Anti-Aging Trend in Medicine and Gerontology and its Impact on the Immune Status of an Elderly Person

“…Investigation of the impact of WBV training, including longterm neuromuscular stimulation, which causes acute and prolonged physiological effects in the human and animal organism, is actualized by the perspective use of modern innovative technologies of medical rehabilitation. 1,12 There is a significant clinical efficacy in the treatment and prevention of osteoporosis, muscle hypotrophy and postural control in elderly, fibromyalgia, disorders of movement (in patients after stroke or with Parkinson's disease and multiple sclerosis). [2][3][4][5][6][7][8][9] It is known that functionally active, "working" muscles are considered as an immunoendocrine organ on the basis that skeletal muscles synthesize and secrete a large number of regulatory peptidemyokines and cytokines, in particular IL-6.…”

Cryogel biomaterials for neuroscience applications

“…Creating conduits to withstand such forces can require increased tube wallthickness and decreased porosity which raises the issue of permeability limitations for nutrients and cells (Chiono and Tonda-Turo, 2015). It has been shown that wall-thicknesses exceeding 0.81 mm substantially reduces axonal growth and regeneration (Pyatin et al, 2017). However, whilst increasing porosity and decreasing the wall-thickness improves the nutrient, oxygen and cell influx, they in turn negatively affect the mechanical guide (Chiono and Tonda-Turo, 2015;Nectow et al, 2012).…”

MicroCT optimisation for imaging fascicular anatomy in peripheral nerves

“…Our recommendation for the microCT imaging of the vagus and similar peripheral nerves is the staining with 1% Lugol's solution for five days per 4 cm of nerve, wrapping in cling film and mounting in sponge within a tube, and scanning at 35 kVp energy, 114 µA current, 4 W power and an exposure of 0.25 fps, with a molybdenum target. This simplified method for imaging fascicles could not only be used to decipher the fascicular anatomy of the vagus nerve for selective stimulation but could be integrated into studies on all peripheral nerves to study peripheral nerve repair, microsurgery or improving the implementation of nerve guidance conduits for which advanced knowledge of the fascicular anatomy could prove helpful (Grinsell and Keating, 2014;Pyatin et al, 2017;Urbaniak, 1982).…”