Recent Patents Applications in Red Biotechnology: A Mini-Review

Graciano, Raissa; Ribeiro, Júlia Antunes Tavares; Macêdo, Anderson Kelvin Saraiva; Lavareda, José Paulo de S; Oliveira, Pedro; Netto, Jairo B; Nogueira, Lais Moreira; Machado, Juliana Martins; Campos-da-Paz, Mariana; Giunchetti, Rodolfo Cordeiro; Galdino, Alexsandro Sobreira

doi:10.2174/1872208313666190114150511

Cited by 15 publications

(12 citation statements)

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“…Considering that the sandfly's blood meal and the parasite's interaction with the invertebrate host are determining factors for Leishmania transmission, our research group has been developing studies focused on these factors so as to interfere with the parasite transmission dynamic (Graciano et al, 2019). The incorporation of vector antigens into new immunobiologicals is a promising strategy designed to disrupt the sandflies' life cycle, as well as block L. infantum transmission (Graciano et al, 2019). In fact, our research group has already identified different formulations with these capabilities that are currently being analyzed in addition to Leishmania antigens.…”

Section: Discussion and Perspectives: Immunotherapeutic Strategies Tomentioning

confidence: 99%

“…Recently, a newly patented vaccine using non-salivary antigens from sandflies has shown promise as a vector control strategy because it impairs its life cycle in addition to blocking Leishmania infection in sandflies. This approach has been considered as the next vaccine frontier for controlling vectorborne diseases (Graciano et al, 2019).…”

Section: Current Control Methods Based On Sandfly Interference To Blomentioning

confidence: 99%

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An Overview of Immunotherapeutic Approaches Against Canine Visceral Leishmaniasis: What Has Been Tested on Dogs and a New Perspective on Improving Treatment Efficacy

Gonçalves

Leite

Resende

et al. 2019

Front. Cell. Infect. Microbiol.

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Section: Discussion and Perspectives: Immunotherapeutic Strategies Tomentioning

confidence: 99%

Section: Current Control Methods Based On Sandfly Interference To Blomentioning

confidence: 99%

An Overview of Immunotherapeutic Approaches Against Canine Visceral Leishmaniasis: What Has Been Tested on Dogs and a New Perspective on Improving Treatment Efficacy

Gonçalves

Leite

Resende

et al. 2019

Front. Cell. Infect. Microbiol.

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“…Another type of approach targets vector control and parasite transmission strategies through the development of transmission blocking vaccines (TBVs) [49]. In this approach, the parasite's transmission is interrupted by the host's immune response to the parasite's targeted proteins, such as pre-fertilization and post-fertilization antigens [50,51].…”

Section: Sexual Stagementioning

confidence: 99%

A Review of Major Patents on Potential Malaria Vaccine Targets, Including Antigens from Different Stages of The Parasite Cycle

Mariano¹,

Gonçalves²,

Oliveira³

et al. 2023

Preprint

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Malaria is a parasitic infection that is a great public health concern and is responsible for high mortality rates worldwide. Different strategies have been employed to improve disease control, demonstrating the ineffectiveness of controlling vectors, and parasite resistance to antimalarial drugs requires the development of an effective preventive vaccine. There are countless challenges to the development of such a vaccine directly related to the parasite's complex life cycle. After more than four decades of basic research and clinical trials, the World Health Organization (WHO) has recommended the pre-erythrocytic Plasmodium falciparum (RTS, S) malaria vaccine for widespread use among children living in malaria-endemic areas. However, there is a consensus that major improvements are needed to develop a vaccine with a greater epidemiological impact in endemic areas. This review discusses novel strategies for malaria vaccine design taking the target stages within the parasite cycle into account. The design of the multi-component vaccine shows considerable potential, especially as it involves transmission-blocking vaccines (TBVs) that eliminate the parasite's replication towards sporozoite stage parasites during a blood meal of female anopheline mosquitoes. Significant improvements have been made but additional efforts to achieve an efficient vaccine are required to improve control measures. Different strategies have been employed, thus demonstrating the ineffectiveness in controlling vectors, and parasite resistance to antimalarial drugs requires the development of a preventive vaccine. Despite having a vaccine in an advanced stage of development, such as the RTS, S malaria vaccine, the search for an effective vaccine against malaria is far from over. This review discusses novel strategies for malaria vaccine design taking into account the target stages within the parasite’s life cycle.

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“…Biotechnology is divided into four colors, Red, Blue, White, Green and other additional colors define the areas, as shown in figure 17a. Our focus is on the red color [127], which is Medical or biomedical engineering. Biomedical plays a vital role in predicting and classifying diseases in healthcare.…”

Section: Qml In Biomedical Domainmentioning

confidence: 99%

Quantum Machine Learning Applications in the Biomedical Domain: A Systematic Review

2022

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Quantum technologies have become powerful tools for a wide range of application disciplines, which tend to range from chemistry to agriculture, natural language processing, and healthcare due to exponentially growing computational power and advancement in machine learning algorithms. Furthermore, the processing of classical data and machine learning algorithms in the quantum domain has given rise to an emerging field like quantum machine learning. Recently, quantum machine learning, become a quite challenging field in case of healthcare applications. As a result, quantum machine learning has become a common and effective technique for data processing and classification across a wide range of domains. Consequently, quantum machine learning is the most commonly used application of quantum computing. The main objective of this work is to present a brief overview of current state-of-the-art published articles between 2013 and 2021 to identify, analyze, and classify the different QML algorithms and applications in the biomedical field. Furthermore, the approach adheres to the requirements for conducting systematic literature review techniques such as research questions and quality metrics of the articles. Initially, we discovered 3149 articles, excluded the 2847 papers, and read the 121 full papers. Therefore, this research compiled 30 articles that comply with the quantum machine learning models, and quantum circuits are using biomedical data. Eventually, this article provides a broad overview of quantum machine learning limitations and future prospects.

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Recent Patents Applications in Red Biotechnology: A Mini-Review

Cited by 15 publications

References 0 publications

An Overview of Immunotherapeutic Approaches Against Canine Visceral Leishmaniasis: What Has Been Tested on Dogs and a New Perspective on Improving Treatment Efficacy

An Overview of Immunotherapeutic Approaches Against Canine Visceral Leishmaniasis: What Has Been Tested on Dogs and a New Perspective on Improving Treatment Efficacy

A Review of Major Patents on Potential Malaria Vaccine Targets, Including Antigens from Different Stages of The Parasite Cycle

Quantum Machine Learning Applications in the Biomedical Domain: A Systematic Review

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