Recent progress and research trend of anti-cataract pharmacology therapy: A bibliometric analysis and literature review

Lu, Ao; Duan, Ping; Xie, Jun; Gao, Hui; Chen, Mengmeng; Gong, Yu; Li, Jiawen; Xu, Haiwei

doi:10.1016/j.ejphar.2022.175299

Cited by 15 publications

(3 citation statements)

References 189 publications

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“…Second, this study only analyzes for the whole country and does not include geographical conditions, economic conditions, provinces, cities, rural areas and other factors, but the prevalence of cataract in China varies considerably among regions [12,18,[68][69][70][71] . Third, cataract is multifactorial, but the database does not provide some of the risk factors such as nutrition [72] , drugs [73] , other eye diseases and systemic diseases [74] and thus these factors were not covered in this study. Over the three decades from 1990 to 2019, the burden of cataract in China presented an upward tendency, with a higher burden in females.…”

Section: Chinese Cataract Burden and Predictionsmentioning

confidence: 99%

Time trends and gender disparities of Chinese cataract burden and their predictions

Wu,

Liu,

et al. 2023

Int J Ophthalmol

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AIM: To evaluate the trends and changes in the number and rates of disability-adjusted life years (DALYs) and prevalence of cataract in China between 1990 and 2019, and to predict the trends of cataract burden from 2020 to 2030. METHODS: The Global Burden of Diseases (GBD) database was employed to collect the data on DALYs and the prevalence of cataract in China, which was distinguished by age and sex during the past three decades from 1990 to 2019, and then changes in the number and rates of cataract from 2020 to 2030 were predicted. All data were analyzed by the R program (version 4.2.2) and GraphPad Prism 9.0 statistics software. RESULTS: The number of DALYs of cataract increased from 449 322.84 in 1990 to 1 087 987.61 in 2019, number of cataract cases increased from 5 607 600.94 in 1990 to 18 142 568.96 in 2019. The age-standardized DALY rates (ASDR) generally increased slightly [estimated annual percentage change (EAPC=0.1; 95%CI: -0.24 to 0.45), age-standardized prevalence rates (ASPR) also increased (EAPC=0.88; 95%CI: 0.6 to 1.15). Cataract burden increased with age and female gender. Among the causes of cataract, air pollution was the most important, followed by smoking, high fasting plasma glucose, and high body mass index (BMI). The burden of cataract is predicted to grow persistently from 2020 to 2030, the number of DALYs and prevalence for cataract will rise to 2 336 431 and 43 698 620 respectively by 2030, the ASDR is predicted to be 85/100 000 and ASPR will be 1586/100 000 in 2030, females will still be at greater risk of suffering from cataract than males. CONCLUSION: The burden of cataract in China kept rising from 1990 to 2019. Increasing age and female gender are risk factors for cataract. Air pollution, smoking, high fasting plasma glucose, and high BMI are associated with cataract. The burden of cataract in China will gradually increase from 2020 to 2030, the elderly women in particular need attention. Our results may be of help for providing reference strategies to reduce cataract burden in the near future.

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Section: Chinese Cataract Burden and Predictionsmentioning

confidence: 99%

Time trends and gender disparities of Chinese cataract burden and their predictions

Wu,

Liu,

et al. 2023

Int J Ophthalmol

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“…Thus, cataract can also be classified as acquired, generally when derived from primary conditions. High levels of glucose (diabetic cataract), ionizing radiation (radiation cataract), and alteration in intraocular pression (glaucoma) are common triggers of cataract, besides aging (age-related cataract) (Lu et al, 2022) [ 97 ]. These primary disorders produce high levels of reactive oxygen species (ROS), which are counterbalanced by the protective antioxidant system.…”

Section: Zebrafish As a Model For Ocular Pathologiesmentioning

confidence: 99%

An Overview towards Zebrafish Larvae as a Model for Ocular Diseases

Rosa

Lopes-Ferreira

Lima

2023

IJMS

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Despite the obvious morphological differences in the visual system, zebrafish share a similar architecture and components of the same embryonic origin as humans. The zebrafish retina has the same layered structure and cell types with similar metabolic and phototransduction support as humans, and is functional 72 h after fertilization, allowing tests of visual function to be performed. The zebrafish genomic database supports genetic mapping studies as well as gene editing, both of which are useful in the ophthalmological field. It is possible to model ocular disorders in zebrafish, as well as inherited retinal diseases or congenital or acquired malformations. Several approaches allow the evaluation of local pathological processes derived from systemic disorders, such as chemical exposure to produce retinal hypoxia or glucose exposure to produce hyperglycemia, mimicking retinopathy of prematurity or diabetic retinopathy, respectively. The pathogenesis of ocular infections, autoimmune diseases, or aging can also be assessed in zebrafish larvae, and the preserved cellular and molecular immune mechanisms can be assessed. Finally, the zebrafish model for the study of the pathologies of the visual system complements certain deficiencies in experimental models of mammals since the regeneration of the zebrafish retina is a valuable tool for the study of degenerative processes and the discovery of new drugs and therapies.

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“…Bibliometric analysis is widely used in the field of ophthalmology and provides significant assistance in both research and clinical settings. It has been applied to various areas, such as the study of anti-cataract medications, research on dry eye syndrome, and investigations into the development of myopia [ 14 – 16 ]. VKHD is a complex and multifaceted condition whose study involves a variety of topics, such as epidemiology, clinical manifestations, pathogenesis, diagnosis, and treatment.…”

Section: Introductionmentioning

confidence: 99%

Bibliometric analysis of the Vogt‒Koyanagi‒Harada disease literature

Li¹,

Liu²,

Zhou³

et al. 2023

Int Ophthalmol

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Purpose As an autoimmune disease, Vogt‒Koyanagi‒Harada disease (VKHD) is a main type of uveitis in many countries and regions, significantly impacting patient vision. At present, information regarding VKHD is still limited, and further research is needed. We conducted a bibliometric analysis to characterize the overall status, current trends, and current focus of VKHD research. Method Literature published from 1975 to 2022 was obtained from the Web of Science core collection and analysed with the R-language packages Bibliometrix, VOSviewer, and CiteSpace software. Results A total of 1050 papers on VKHD were retrieved from 261 journals, and 16,084 references were obtained from the papers in the original search. The average annual number of published articles was approximately 21.9, and the number of publications rapidly increased after 2004. The journal Ocular Immunology and Inflammation published the most papers on VKHD, while the American Journal of Ophthalmology has the highest citation frequency. The leading countries were Japan, China (PRC), and the United States of America (USA). Yang PZ from Chongqing Medical University was the most prolific and cited author. The most frequently cited study discussed revision of VKHD diagnostic criteria. An analysis of the highest frequency keywords showed that most research focused on the treatment, diagnosis, and pathogenesis of VKHD and its relationship with other related diseases. At present, the most urgent research direction is in the relationship between COVID-19 or COVID-19 vaccines and VKHD and the corresponding mechanisms underlying it. Conclusion Utilizing dynamic and visualization tools, bibliometrics provides a clear depiction of the research history, development trends, and research hotspots in VKHD It serves as a valuable tool for identifying research gaps and areas that necessitate further exploration. Our study revealed potential directions for future VKHD research, including investigating specific molecular mechanisms underlying the disease, exploring the clinical utility of optical coherence tomography angiography and other diagnostic techniques, and conducting clinical research on novel therapeutic drugs.

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Recent progress and research trend of anti-cataract pharmacology therapy: A bibliometric analysis and literature review

Cited by 15 publications

References 189 publications

Time trends and gender disparities of Chinese cataract burden and their predictions

Time trends and gender disparities of Chinese cataract burden and their predictions

An Overview towards Zebrafish Larvae as a Model for Ocular Diseases

Bibliometric analysis of the Vogt‒Koyanagi‒Harada disease literature

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