Recent progress in development of new sonosensitizers for sonodynamic cancer therapy

Chen, Haijun; Zhou, Xiujuan; Gao, Yu; Zheng, Biyuan; Tang, Fengxiang; Huang, Jian‐Dong

doi:10.1016/j.drudis.2014.01.010

Cited by 310 publications

(235 citation statements)

References 58 publications

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“…Many molecules were employed in SDT, such as porphyrins, some antitumor drugs and various types of NPs [86,89]. It is also been reported in literature the use of microbubbles as adjuvant for the sonosensitizers: these can be employed both as carrier of molecules and as contrast agents for imaging purposes.…”

Section: Sonodynamic Therapymentioning

confidence: 99%

See 1 more Smart Citation

Nanoparticle-assisted ultrasound: A special focus on sonodynamic therapy against cancer

Canavese

Ancona

Racca

et al. 2018

Chemical Engineering Journal

351

247

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• Ultrasound-based therapies are opening new horizons in the oncological field.• Innovative and promising solutions derive from different nanoparticles-assisted ultrasound treatments.• Sonodynamic therapy (SDT) emerged recently as a novel approach for cancer treatment.• Different and complex cell death mechanisms are involved in nanoparticles-assisted SDT.• Nanoparticles-assisted ultrasound is still at its infancy in clinics. A R T I C L E I N F O Keywords:Inertial cavitation Reactive oxygen species Sonoluminescence Sonodynamic Tumor Therapy Cytotoxicity A B S T R A C TAt present, ultrasound radiation is broadly employed in medicine for both diagnostic and therapeutic purposes at various frequencies and intensities. In this review article, we focus on therapeutically-active nanoparticles (NPs) when stimulated by ultrasound. We first introduce the different ultrasound-based therapies with special attention to the techniques involved in the oncological field, then we summarize the different NPs used, ranging from soft materials, like liposomes or micro/nano-bubbles, to metal and metal oxide NPs. We therefore focus on the sonodynamic therapy and on the possible working mechanisms under debate of NPs-assisted sonodynamic treatments. We support the idea that various, complex and synergistics physical-chemical processes take place during acoustic cavitation and NP activation. Different mechanisms are therefore responsible for the final cancer cell death and strongly depends not only on the type and structure of NPs or nanocarriers, but also on the way they interact with the ultrasonic pressure waves. We conclude with a brief overview of the clinical applications of the various ultrasound therapies and the related use of NPs-assisted ultrasound in clinics, showing that this very innovative and promising approach is however still at its infancy in the clinical cancer treatment.

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Section: Sonodynamic Therapymentioning

confidence: 99%

“…It is based on the use of low-intensity ultrasound and a molecule, called sonosensitizer, that is sonically activated [86]. Although SDT therapeutic efficacy has been extensively demonstrated, the exact working mechanism is still under debate and will be further discussed below.…”

Section: Sonodynamic Therapymentioning

confidence: 99%

Nanoparticle-assisted ultrasound: A special focus on sonodynamic therapy against cancer

Canavese

Ancona

Racca

et al. 2018

Chemical Engineering Journal

351

247

View full text Add to dashboard Cite

show abstract

“…Discovery and development of novel sensitizers are becoming the major focus of recent investigation in this field [27]. In order to improve the sonodynamic cancer therapy, we developed a core-shell polymer-based nanoparticle, namely PMMANPs, carrying porphyrin to be in vivo triggered by ultrasound applied as shock wave mode.…”

Section: Discussionmentioning

confidence: 99%

“…Among the sonosensitizers, porphyrin-type molecules have been extensively applied in SDT [27]. In addition, the use of nanoparticles as carriers of the sonosensitizer might provide an additional advantage with respect to nanoparticle-mediated drug delivery.…”

Section: Introductionmentioning

confidence: 99%

Engineered Porphyrin Loaded Core-Shell Nanoparticles for Selective Sonodynamic Anticancer Treatment

Varchi

Foglietta

Canaparo

et al. 2015

Nanomedicine (Lond.)

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“…Current treatment options for NSCLC are radiotherapy and chemotherapy, both which have their limitations such as toxicity, serious systemic side-effects, low selectivity and resistance [6]. The systemic administration of chemotherapeutic drugs has its limitations due to the need for higher dose, which result in serious adverse side-effects as these drugs destroy both cancerous and healthy cells [7][8].…”

Section: Introductionmentioning

confidence: 99%

Development and characterisation of disulfiram-loaded PLGA nanoparticles for the treatment of non-small cell lung cancer

Najlah

Ahmed

Iqbal

et al. 2017

European Journal of Pharmaceutics and Biopharmaceutics

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Non-Small Cell Lung Cancer (NSCLC) is the most common type of lung cancer in both men and women. A recent phase IIb study demonstrated that disulfiram (DSF) in combination with cisplatin and vinorelbine was well tolerated and prolonged the survival of patients with newly diagnosed NSCLC. However, DSF is rapidly (4 minutes) metabolised in the bloodstream and it is this issue which is limiting its anticancer application in the clinic. We have recently demonstrated that a low dose of DSF-loaded PLGA nanoparticles supplemented with oral Cu inhibited tumour growth and reduced metastasis in a xenograft mouse lung cancer model. Here we demonstrate the influence of PLGA polymer, stabilizer loading and molecular weight as well as sonication time on the characteristics, including DSF release and the cytotoxicity of 10% w/w DSF-loaded PLGA nanoparticles. The paper demonstrates that the choice of PLGA as no significant influence on the characteristics of the nanoparticles apart from their DSF release, which is due to the differing degradation rates of the polymers. However, increasing the loading and molecular weight of the stabilizer as well as the sonication time reduced the size of the nanoparticles, reduced their ability to protect the DSF from reacting with Cu and degrading in serum, while increasing their DSF release rate and cytotoxicity. Additionally, increasing the sonication time resulted in the premature degradation of the PLGA, which increased the permeability of the nanoparticles further decreasing their ability to protect DSF from reacting with Cu and degrading in serum, while increasing their DSF release rate and cytotoxicity.

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Recent progress in development of new sonosensitizers for sonodynamic cancer therapy

Cited by 310 publications

References 58 publications

Nanoparticle-assisted ultrasound: A special focus on sonodynamic therapy against cancer

Nanoparticle-assisted ultrasound: A special focus on sonodynamic therapy against cancer

Engineered Porphyrin Loaded Core-Shell Nanoparticles for Selective Sonodynamic Anticancer Treatment

Development and characterisation of disulfiram-loaded PLGA nanoparticles for the treatment of non-small cell lung cancer

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