Recent Progress in Electrospun Polyacrylonitrile Nanofiber-Based Wound Dressing

Huang, Chang; Xu, Xizi; Fu, Junhao; Yu, Deng‐Guang; Liu, Yanbo

doi:10.3390/polym14163266

Cited by 67 publications

(50 citation statements)

References 248 publications

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“…The homemade electrospinning system was used to fabricate fibers, which was composed of 4 parts: A high-voltage (60 kV/2 mA) power supply (ZGF2000, Shanghai Sute Corp., Shanghai, China), two syringe pumps (KDS100 and KDS200, Cole-Parmer, Lake County, IL, USA), a homemade concentric spinneret and a piece of aluminum foil wrapped on the cardboard as a collector [ 55 , 56 , 57 , 58 ].…”

Section: Methodsmentioning

confidence: 99%

Electrospun Zein/Polyoxyethylene Core-Sheath Ultrathin Fibers and Their Antibacterial Food Packaging Applications

et al. 2022

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The purpose of this work is to develop a novel ultrathin fibrous membrane with a core-sheath structure as antibacterial food packaging film. Coaxial electrospinning was exploited to create the core-sheath structure, by which the delivery regulation of the active substance was achieved. Resveratrol (RE) and silver nanoparticles (AgNPs) were loaded into electrospun zein/polyethylene oxide ultrathin fibers to ensure a synergistic antibacterial performance. Under the assessments of a scanning electron microscope and transmission electron microscope, the ultrathin fiber was demonstrated to have a fine linear morphology, smooth surface and obvious core-sheath structure. X-ray diffraction and Fourier transform infrared analyses showed that RE and AgNPs coexisted in the ultrathin fibers and had good compatibility with the polymeric matrices. The water contact angle experiments were conducted to evaluate the hydrophilicity and hygroscopicity of the fibers. In vitro dissolution tests revealed that RE was released in a sustained manner. In the antibacterial experiments against Staphylococcus aureus and Escherichia coli, the diameters of the inhibition zone of the fiber were 8.89 ± 0.09 mm and 7.26 ± 0.10 mm, respectively. Finally, cherry tomatoes were selected as the packaging object and packed with fiber films. In a practical application, the fiber films effectively reduced the bacteria and decreased the quality loss of cherry tomatoes, thereby prolonging the fresh-keeping period of cherry tomatoes to 12 days. Following the protocols reported here, many new food packaging films can be similarly developed in the future.

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Section: Methodsmentioning

confidence: 99%

Electrospun Zein/Polyoxyethylene Core-Sheath Ultrathin Fibers and Their Antibacterial Food Packaging Applications

et al. 2022

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“…In light of the advancements made in tissue engineering, the topic of electrospinning is gaining popularity in the biomedical world. The high available surface area and high porosity of electrospun nanofibers, being affordable and easy to handle, make electrospun nanofibers an ideal option for wound dressing (Kakoria and Sinha-Ray, 2018;Huang et al, 2022). Electrospun nanofibers can be formed by a range of natural polymers such as cellulose, chitosan (CS), collagen, gelatin, and silk, as well as synthetic biodegradable polymers such as polylactic acid (PLA), polyglycolic acid (PGA), and polycaprolactone (PCL) (Mendes et al, 2017;Zhang et al, 2022).…”

Section: Introductionmentioning

confidence: 99%

Fabrication and characterization of polycaprolactone/chitosan nanofibers containing antibacterial agents of curcumin and ZnO nanoparticles for use as wound dressing

Mosallanezhad

Nazockdast

Ahmadi

et al. 2022

Front. Bioeng. Biotechnol.

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The potential of the nanoscale structure is utilized by electrospun nanofibers, which are promising materials for wound dressings. Here, we prepared wound dressings constituting polycaprolactone (PCL) and chitosan (CS). Curcumin (Cur) and zinc oxide nanoparticles (ZnO) as antibacterial agents were embedded in PCL/CS electrospun nanofibers and different properties including morphology, physicomechanical, interaction with water, antibacterial efficiency, and in vitro studies were investigated. SEM images confirmed the nanofibrous structure of samples with 100 ± 5 to 212 ± 25 nm in average diameter. Elemental analysis of nanofibers showed a good distribution of ZnO along nanofibers which not only caused decreasing in nanofiber diameter but also increased tensile strength of nanofibers up to 2.9 ± 0.5 MPa and with good elongation at break of 39 ± 2.9. ZnO nanoparticles also facilitated the interaction of nanofibers with water, and this led to the highest water vapor transition rate, which was equal to 0.28 ± 0.02 g cm−2 day−1. The sample containing 3 wt% Cur had the highest water uptake value (367 ± 15%) and the lowest water contact angle (78 ± 3.7°), although Cur has a hydrophobic nature. The release profile of Cur showed a two-stage release and the Peppas model predicted a non-fickian diffusion. Simultaneous incorporation of CS, ZnO, and Cur effectively inhibited bacterial growth. In addition, in vitro studies represented that high content of Cur decreases cell viability and cell attachment. The outcomes from the fabricated nanofibrous scaffolds demonstrated appropriate properties for application as a wound dressing.

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“…The application potential includes topical delivery of drugs for breaks or ulcers in the gastrointestinal tract, urethra, vagina, etc., although there are still many challenges to be solved for the application of nanofibers prepared by electrospinning in oral ulcers. However, electrospinning technology has a broad future in the preparation of adherent patches for topical drug delivery and for expanding the applications of biomolecules [ 176 , 177 , 178 , 179 ].…”

Section: Discussionmentioning

confidence: 99%

Advances in the Application of Electrospun Drug-Loaded Nanofibers in the Treatment of Oral Ulcers

et al. 2022

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Oral ulcers affect oral and systemic health and have high prevalence in the population. There are significant individual differences in the etiology and extent of the disease among patients. In the treatment of oral ulcers, nanofiber films can control the drug-release rate and enable long-term local administration. Compared to other drug-delivery methods, nanofiber films avoid the disadvantages of frequent administration and certain side effects. Electrospinning is a simple and effective method for preparing nanofiber films. Currently, electrospinning technology has made significant breakthroughs in energy-saving and large-scale production. This paper summarizes the polymers that enable oral mucosal adhesion and the active pharmaceutical ingredients used for oral ulcers. Moreover, the therapeutic effects of currently available electrospun nanofiber films on oral ulcers in animal experiments and clinical trials are investigated. In addition, solvent casting and cross-linking methods can be used in conjunction with electrospinning techniques. Based on the literature, more administration systems with different polymers and loading components can be inspired. These administration systems are expected to have synergistic effects and achieve better therapeutic effects. This not only provides new possibilities for drug-loaded nanofibers but also brings new hope for the treatment of oral ulcers.

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Recent Progress in Electrospun Polyacrylonitrile Nanofiber-Based Wound Dressing

Cited by 67 publications

References 248 publications

Electrospun Zein/Polyoxyethylene Core-Sheath Ultrathin Fibers and Their Antibacterial Food Packaging Applications

Electrospun Zein/Polyoxyethylene Core-Sheath Ultrathin Fibers and Their Antibacterial Food Packaging Applications

Fabrication and characterization of polycaprolactone/chitosan nanofibers containing antibacterial agents of curcumin and ZnO nanoparticles for use as wound dressing

Advances in the Application of Electrospun Drug-Loaded Nanofibers in the Treatment of Oral Ulcers

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