Recent progress in host immunity to avian coccidiosis: IL-17 family cytokines as sentinels of the intestinal mucosa

Min, Wongi; Kim, Woo Hyun; Lillehoj, Erik P.; Lillehoj, Hyun S.

doi:10.1016/j.dci.2013.04.003

Cited by 81 publications

(70 citation statements)

References 181 publications

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“…Eimeria species, etiological agents of distinct gastrointestinal diseases, cause the most costly diseases that affect the poultry industry worldwide (21,52). The chIL-17A expression increases in the duodenum and jejunum of E. acervulina-and E. maximainfected chickens, respectively (53,54).…”

Section: Discussionmentioning

confidence: 99%

“…The growing literature on the importance of the IL-17/IL-17R axis in host defense includes many studies that describe the critical role of the IL-17 family of cytokines in avian immune responses (19)(20)(21)(22). Three cytokines-IL-17A, IL-17D, and IL-17F-have been identified in an expressed sequence tag (EST) cDNA library prepared from intestinal intraepithelial lymphocytes (IELs) of Eimeria-infected chickens (23), from a testis cDNA library prepared from Korean native chickens (24), and from concanavalin A (ConA)-activated chicken splenic lymphocytes (19), respectively.…”

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Downregulation of Chicken Interleukin-17 Receptor A during Eimeria Infection

et al. 2014

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e Both interleukin-17A (IL-17A) and IL-17F are proinflammatory cytokines that have an important role in intestinal homeostasis via receptor signaling. These cytokines have been characterized in chickens, but very little is known about their receptors and their functional activity. We provide here the first description of the sequence analysis, bioactivity, and comparative expression analysis of chicken IL-17RA (chIL-17RA) in chickens infected with Salmonella and Eimeria, two major infectious agents of gastrointestinal diseases of poultry of economic importance. A full-length chIL-17RA cDNA with a 2,568-bp coding region was identified from chicken thymus cDNA. chIL-17RA shares ca. 46% identity with mammalian homologues and 29.2 to 31.5% identity with its piscine counterparts. chIL-17RA transcript expression was relatively high in the thymus and in the chicken macrophage cell line HD11. The chIL-17RA-specific small interfering RNA inhibits interleukin-6 (IL-6), IL-8, and IL-1␤ mRNA expression in chicken embryo fibroblast cells (but not in DF-1 cells) stimulated with chIL-17A or chIL-17F. Interaction between chIL-17RA and chIL-17A was confirmed by coimmunoprecipitation. Downregulation of chIL-17RA occurred in concanavalin A-or lipopolysaccharide-activated splenic lymphocytes but not in poly(I·C)-activated splenic lymphocytes. In Salmonella-and Eimeria-infected chickens, the expression levels of the chIL-17RA transcript were downregulated in intestinal tissues from chickens infected with two Eimeria species, E. tenella or E. maxima, that preferentially infect the cecum and jejunum, respectively. However, chIL-17RA expression was generally unchanged in Salmonella infection. These results suggest that chIL-17RA has an important role in mucosal immunity to intestinal intracellular parasite infections such as Eimeria infection.

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Section: Discussionmentioning

confidence: 99%

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Downregulation of Chicken Interleukin-17 Receptor A during Eimeria Infection

et al. 2014

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“…and bind the same receptors. Thus, these two cytokines are likely to have similar and/or overlapping biological activities (Moseley et al, 2003;Min et al, 2013). Although they have been shown to have some similar functions, IL-17A and IL-17F have been suggested by some studies to be differentially regulated and to have their own distinct activities (Yang et al, 2008;Ishigame et al, 2009).…”

Section: Introductionmentioning

confidence: 95%

Molecular cloning, characterization and mRNA expression of duck interleukin-17F

Kim

Fernandez

Diaz

et al. 2015

Veterinary Immunology and Immunopathology

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“…Regardless, intestinal transcription of IFN-γ and IL-10 was not differentially affected by dietary vitD supply. Eimeria maxima evokes a complex cytokine response characterized by increased production of Th1 pro-inflammatory cytokines such as IL-1b, IL-6, IL-8, IL-17, and IFN-γ in the small intestine, as well as Th2 anti-inflammatory cytokines such as IL-4, IL-10 (35,59,60) . In particular, increased IFN-γ mRNA levels are thought to associate with antigen-specific resistance to coccidiosis, promoting Th1 cell production, whilst preventing Th2 cell production (36,61) , balanced by IL-10 (62) .…”

Section: Discussionmentioning

confidence: 99%

Dietary vitamin D improves performance and bone mineralisation, but increases parasite replication and compromises gut health in Eimeria-infected broilers

et al. 2019

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Coccidial infections reduce fat-soluble vitamin status and bone mineralisation in broiler chickens. We hypothesised that broilers infected with Eimeria maxima would benefit from increased dietary supplementation with vitamin D (vitD) or with 25-hydroxycholecalciferol (25(OH)D3 or 25D3). Broilers were assigned to diets with low (L) or commercial (M) vitD levels (25 v. 100 μg/kg) supplemented as cholecalciferol (D3) or 25D3. At day 11 of age, birds were inoculated with water or 7000 E. maxima oocysts. Pen performance was calculated over the early (days 1–6), acute (days 7–10) and recovery periods (days 11–14) post-infection (pi). At the end of each period, six birds per treatment were dissected to assess long bone mineralisation, plasma levels of 25D3, Ca and P, and intestinal histomorphometry. Parasite replication and transcription of cytokines IL-10 and interferon-γ (IFN-γ) were assessed at day 6 pi using quantitative PCR. Performance, bone mineralisation and plasma 25D3 levels were significantly reduced during infection (P < 0·05). M diets or diets with 25D3 raised plasma 25D3, improved performance and mineralisation (P < 0·05). Offering L diets compromised feed efficiency pi, reduced femur breaking strength and plasma P levels at day 10 pi in infected birds (P < 0·05). Contrastingly, offering M diets or diets with 25D3 resulted in higher parasite loads (P < 0·001) and reduced jejunal villi length at day 10 pi (P < 0·01), with no effect on IL-10 or IFN-γ transcription. Diets with M levels or 25D3 improved performance and mineralisation, irrespective of infection, while M levels further improved feed efficiency and mineralisation in the presence of coccidiosis.

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Recent progress in host immunity to avian coccidiosis: IL-17 family cytokines as sentinels of the intestinal mucosa

Cited by 81 publications

References 181 publications

Downregulation of Chicken Interleukin-17 Receptor A during Eimeria Infection

Downregulation of Chicken Interleukin-17 Receptor A during Eimeria Infection

Molecular cloning, characterization and mRNA expression of duck interleukin-17F

Dietary vitamin D improves performance and bone mineralisation, but increases parasite replication and compromises gut health in Eimeria-infected broilers

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