Recent progress in lab-on-a-chip for pharmaceutical analysis and pharmacological/toxicological test

Ai, Yongjian; Zhang, Feng; Wang, Chenlong; Xie, Ruoxiao; Liang, Qionglin

doi:10.1016/j.trac.2019.06.026

Cited by 62 publications

(39 citation statements)

References 209 publications

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“…However, they have not been extensively utilized in microchip manufacturing due to the harsh operating conditions. What is more, the price of glass/silicon chip is higher than that of a plastic chip …”

Section: Microfluidics For the Fabrication And Manipulation Of Dropletsmentioning

confidence: 99%

Microfluidics for Biosynthesizing: from Droplets and Vesicles to Artificial Cells

Xie

Xiong

et al. 2019

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Fabrication of artificial biomimetic materials has attracted abundant attention. As one of the subcategories of biomimetic materials, artificial cells are highly significant for multiple disciplines and their synthesis has been intensively pursued. In order to manufacture robust “alive” artificial cells with high throughput, easy operation, and precise control, flexible microfluidic techniques are widely utilized. Herein, recent advances in microfluidic‐based methods for the synthesis of droplets, vesicles, and artificial cells are summarized. First, the advances of droplet fabrication and manipulation on the T‐junction, flow‐focusing, and coflowing microfluidic devices are discussed. Then, the formation of unicompartmental and multicompartmental vesicles based on microfluidics are summarized. Furthermore, the engineering of droplet‐based and vesicle‐based artificial cells by microfluidics is also reviewed. Moreover, the artificial cells applied for imitating cell behavior and acting as bioreactors for synthetic biology are highlighted. Finally, the current challenges and future trends in microfluidic‐based artificial cells are discussed. This review should be helpful for researchers in the fields of microfluidics, biomaterial fabrication, and synthetic biology.

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Section: Microfluidics For the Fabrication And Manipulation Of Dropletsmentioning

confidence: 99%

Microfluidics for Biosynthesizing: from Droplets and Vesicles to Artificial Cells

Xie

Xiong

et al. 2019

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Self Cite

121

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“…Recent reviews have well summarized the current state of lab-on-a-chip and pharm-on-a-chip in the determination of PK, PD, toxicokinetic, and toxicodynamic parameters of target drugs. 127,128 Although the initial motivation for the DARPA, NCATS, and FDA MPS programs was to address unanticipated toxicity, drug failures due to toxicity are now less common than failures in efficacy, and, as a result, it is recognized that MPS approaches will provide a greater return on investment when focused on drug mechanism of action and PK/PD. 3 Much of the effort by the MPS community to date has been to demonstrate and validate specific tissue chips.…”

Section: Oocs For In Vitro Studies Of Microbiome-organ-organ Interactmentioning

confidence: 99%

The Microbiome and the Gut‐Liver‐Brain Axis for Central Nervous System Clinical Pharmacology: Challenges in Specifying and Integrating In Vitro and In Silico Models

Hawkins

Casolaro

Brown

et al. 2020

Clin Pharma and Therapeutics

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The complexity of integrating microbiota into clinical pharmacology, environmental toxicology, and opioid studies arises from bidirectional and multiscale interactions between humans and their many microbiota, notably those of the gut. Hosts and each microbiota are governed by distinct central dogmas, with genetics influencing transcriptomics, proteomics, and metabolomics. Each microbiota's metabolome differentially modulates its own and the host's multi‐omics. Exogenous compounds (e.g., drugs and toxins), often affect host multi‐omics differently than microbiota multi‐omics, shifting the balance between drug efficacy and toxicity. The complexity of the host‐microbiota connection has been informed by current methods of in vitro bacterial cultures and in vivo mouse models, but they fail to elucidate mechanistic details. Together, in vitro organ‐on‐chip microphysiological models, multi‐omics, and in silico computational models have the potential to supplement the established methods to help clinical pharmacologists and environmental toxicologists unravel the myriad of connections between the gut microbiota and host health and disease.

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“…Há uma gama de aplicações para os dispositivos LOC, que vão desde a investigação de moléculas individuais, eletroforese capilar, monitoramento ambiental, estudo de processos celulares, passando por cristalização de proteínas, síntese de peptídeos e análises bioquímicas. 94,97 Dentre as aplicações que mais cresceram nas duas últimas décadas foi o uso como sondas eletroquímicas em detecções e quantificações de pesticidas e metais, como sensores seletivos não-enzimáticos de marcadores de doenças, análise farmacêutica e testes farmacológicos/ toxicológicos, 98 monitoramento ambiental, 99 e aplicação de "lab-on-a-chip" microfluídico para detecção de micotoxinas em alimentos. 100…”

Section: Eletrodos Impressos E "Laboratório Em Um úNico Chip" (Lab-onunclassified

Electrochemistry: Modified Electrodes and their Potentialities

Monteiro¹,

Júnior²,

Sussuchi³

2020

Rev. Virtual Quim.

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Electrochemical sensors are analytical tools that offer great portability, ease automation, miniaturization capability, and low cost compared to other analytical techniques and methods. For those reasons, there is a growing search for these electrodes to obtain better analysis conditions. This advance is reflected in new patents and articles, which were intensified mainly with the arising of chemically modified electrodes and self-sufficient equipment. Besides, this study brings together and discusses the main aspects of electrochemical methods, the development of electrodes and their modifiers, as well as the perspectives for these electroanalytical tools. Os sensores eletroquímicos são ferramentas de análise que oferecem maior portabilidade, facilidade de automação, capacidade de miniaturização e baixo custo em relação a outras técnicas e métodos analíticos. Por essas razões, existe uma crescente busca pelo desenvolvimento desses eletrodos a fim de se obter melhores condições de análise. Esse avanço reflete em novas patentes e artigos que se intensificaram, principalmente com o surgimento dos eletrodos quimicamente modificados e equipamentos autossuficientes. Em suma, esse estudo reúne e discute aspectos fundamentais concernentes aos métodos eletroquímicos, o avanço no desenvolvimento dos eletrodos e seus modificantes, além das perspectivas para essas ferramentas eletroanalíticas.

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Recent progress in lab-on-a-chip for pharmaceutical analysis and pharmacological/toxicological test

Cited by 62 publications

References 209 publications

Microfluidics for Biosynthesizing: from Droplets and Vesicles to Artificial Cells

Microfluidics for Biosynthesizing: from Droplets and Vesicles to Artificial Cells

The Microbiome and the Gut‐Liver‐Brain Axis for Central Nervous System Clinical Pharmacology: Challenges in Specifying and Integrating In Vitro and In Silico Models

Electrochemistry: Modified Electrodes and their Potentialities

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