Recent progress in nitric oxide-generating nanomedicine for cancer therapy

Li, Yuce; Yoon, Been; Dey, Anup; Quy, Nguyen Van; Park, Jae Hyung

doi:10.1016/j.jconrel.2022.10.012

Cited by 33 publications

(19 citation statements)

References 217 publications

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“…The study by Xie, et al [22] explored the use of nanoparticle-based delivery of apoptosisinducing agents for the treatment of ULMs. The authors found that this approach was effective in inducing apoptosis in fibroid cells, and suggested that nanoparticle-based delivery of apoptosis-inducing agents may be a promising strategy for the treatment of ULMs.…”

Section: Consequences Of Using Nanomedicinesmentioning

confidence: 99%

A comparative analysis of phytochemicals vs synthetic drugs/nanomedicines in the treatment of Uterine Fibroid: A Systematic Review

Upadhyay

Bhushan

Pandey

et al. 2023

Preprint

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Uterine fibroids (UFs) or leiomyoma is the most common gynaecological disorder affecting 70% of premenopausal women and one of the leading causes of infertility. To date, there is no specific therapy available except surgical intervention including hysterectomy or myomectomy. However, to manage UFs, lot of high cost medications are prescribed although they have serious side effects on women’s reproductive health. Recently an increasing trend has been seen on consuming dietary phytochemicals to control diverse gynaecological ailments. This review's goal is to provide a summary of the knowledge that is currently available regarding the mechanisms of action of various botanical medications with anti-uterine fibroid efficacy. The present results showed that dietary phytocompounds (Dehydroxyelephantopin, Butein, Capsaicin, Fisetin, Kaempferol, Resveratrol, Silibinin and Curcumin) could probably be effective as therapeutic compounds for uterine leiomyoma. These phytochemicals indicated their capability to regulate main fibroid promoting and initiating events for instance, proliferation, inflammation, angiogenesis and fibrosis in various experimental setup through modulating various signalling pathways, such as Smad 2/3, PI3K/AKT/mTOR, ERK 1/2 and β-catenin indicating that they could serve as targets for prevention and/or treatment of ULM. This review provides key molecular insights for development of phytochemical based novel personalized therapy for non-surgical management of ULMs which may help to avoid hysterectomy.

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Section: Consequences Of Using Nanomedicinesmentioning

confidence: 99%

A comparative analysis of phytochemicals vs synthetic drugs/nanomedicines in the treatment of Uterine Fibroid: A Systematic Review

Upadhyay

Bhushan

Pandey

et al. 2023

Preprint

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“…No induced the expression of endogenous angiogenic factors [ 16 , 17 ], thereby normalizing tumor vasculature to improve blood perfusion, relieving tumor hypoxia, and regulating the transition from an immunosuppressive to an immune-supportive TME [ 18 ]. Nevertheless, its clinical application was hindered by the short half-life and purposeless diffusion behavior [ 19 ]. Continuous attempts had been devoted to explore NO donors, such as BNN6 and Nnitrosamines.…”

Section: Introductionmentioning

confidence: 99%

“…However, such donors could cause side effects in vivo [ 20 , 21 ]. Fortunately, L -arginine ( L -Arg), with superior biocompatibility, could produce NO catalyzed by inducible NO synthase (iNOS) or reactive oxygen species (ROS) [ 19 , 22 , 23 ]. As for triggers [ 24 – 26 ], light, heat, and X-ray were commonly used, but they were accompanied by some unavoidable drawbacks, such as poor penetration, low controllability and ionizing radiation, seriously compromising their promising applicability for clinical translation.…”

Section: Introductionmentioning

confidence: 99%

Ultrasound targeted microbubble destruction-triggered nitric oxide release via nanoscale ultrasound contrast agent for sensitizing chemoimmunotherapy

et al. 2023

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Immunotherapy had demonstrated inspiring effects in tumor treatment, but only a minority of people could benefit owing to the hypoxic and immune-suppressed tumor microenvironment (TME). Therefore, there was an urgent need for a strategy that could relieve hypoxia and increase infiltration of tumor lymphocytes simultaneously. In this study, a novel acidity-responsive nanoscale ultrasound contrast agent (L-Arg@PTX nanodroplets) was constructed to co-deliver paclitaxel (PTX) and L-arginine (L-Arg) using the homogenization/emulsification method. The L-Arg@PTX nanodroplets with uniform size of about 300 nm and high drug loading efficiency displayed good ultrasound diagnostic imaging capability, improved tumor aggregation and achieved ultrasound-triggered drug release, which could prevent the premature leakage of drugs and thus improve biosafety. More critically, L-Arg@PTX nanodroplets in combination with ultrasound targeted microbubble destruction (UTMD) could increase cellular reactive oxygen species (ROS), which exerted an oxidizing effect that converted L-Arg into nitric oxide (NO), thus alleviating hypoxia, sensitizing chemotherapy and increasing the CD8 + cytotoxic T lymphocytes (CTLs) infiltration. Combined with the chemotherapeutic drug PTX-induced immunogenic cell death (ICD), this promising strategy could enhance immunotherapy synergistically and realize powerful tumor treatment effect. Taken together, L-Arg@PTX nanodroplets was a very hopeful vehicle that integrated drug delivery, diagnostic imaging, and chemoimmunotherapy. Graphical Abstract

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“…And production of sufficient NO to regulate vascular resistance and maintain blood flow is essential for healthy vascular function. However, the delivery of NO remains severely limited due to its physiological properties such as short half‐life [14], short diffusion distance [15], strong reaction with oxygen radicals and concentration‐dependent therapeutic effects [16]. Thus, special considerations are necessary for the delivery of transporters combined with delivery modes to compensate for the lack of NO in target lesion vessels.…”

Section: Introductionmentioning

confidence: 99%

Tunable catalytic release of nitric oxide via copper‐loaded coatings on titanium nanotubes for regulating biological performance

Li,

Zhang,

Zhou

et al. 2023

Biosurface and Biotribology

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Severe lesions in vessels need to be treated with implantable interventional devices such as vascular stents, which should be anti‐coagulantion, anti‐proliferation and promoting endothelialisation. Nitric oxide (NO), as a physiological gas signalling molecule, play an important role in revascularisation. Catalysing the release of NO from endogenous donors has already been widely favoured to treatment strategy for lesioned vessels. In this work, a series of copper‐loaded coatings (titanium nanotube (TNT)/PDA‐Cu) was fabricated by TNTs combined with polydopamine and ions, which achieve controlled in situ catalytic release of NO. This strategy could effectively immobilised copper ions on TNTs, and promoted the proliferation of endothelial cells and inhibited growth of smooth muscle cells (SMCs) via the performance of NO, as well as restrain the platelet adhesion. With the multiple function, TNT/PDA‐Cu provides a promise approach for promoting endothelialisation, anti‐coagulation and inhibition of SMC proliferation via copper‐loaded coatings on TNTs.

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Recent progress in nitric oxide-generating nanomedicine for cancer therapy

Cited by 33 publications

References 217 publications

A comparative analysis of phytochemicals vs synthetic drugs/nanomedicines in the treatment of Uterine Fibroid: A Systematic Review

A comparative analysis of phytochemicals vs synthetic drugs/nanomedicines in the treatment of Uterine Fibroid: A Systematic Review

Ultrasound targeted microbubble destruction-triggered nitric oxide release via nanoscale ultrasound contrast agent for sensitizing chemoimmunotherapy

Tunable catalytic release of nitric oxide via copper‐loaded coatings on titanium nanotubes for regulating biological performance

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